Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering

Mozafari, Masoud; Moztarzadeh, Fathollah; Rabiee, Mohammad; Azami, Mahmoud; Maleknia, Saied; Tahriri, Mohammadreza; Moztarzadeh, Zoha; Nezafati, Nader

doi:10.1016/j.ceramint.2010.07.010

Cited by 113 publications

(76 citation statements)

References 37 publications

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“…As the first step to reach this goal, the authors made the conductive scaffolds by including PEDOT:PSS CP in the composition of BaG/Gel scaffolds that were optimized previously. 31 It was realized that the addition of PEDOT:PSS can improve various characteristics of the scaffolds including physiochemical stability, mechanical strength, and cell attachment.…”

Section: Discussionmentioning

confidence: 99%

“…30 In a recent investigation, the optimized composition of BaG and Gel for bone tissue scaffolds was reported to be 30:10 (weight percent [wt%] in the stock solution). 31 In this study, 0.1%-0.3% of PEDOT:PSS was added to this optimized value. The results indicate that by increasing PEDOT:PSS, conductivity, cell viability, and mechanical properties were enhanced.…”

Section: Introductionmentioning

confidence: 99%

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3D conductive nanocomposite scaffold for bone tissue engineering

Shahini¹,

Yazdimamaghani²,

Walker³

et al. 2013

IJN

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Bone healing can be significantly expedited by applying electrical stimuli in the injured region. Therefore, a three-dimensional (3D) ceramic conductive tissue engineering scaffold for large bone defects that can locally deliver the electrical stimuli is highly desired. In the present study, 3D conductive scaffolds were prepared by employing a biocompatible conductive polymer, ie, poly(3,4-ethylenedioxythiophene) poly(4-styrene sulfonate) (PEDOT:PSS), in the optimized nanocomposite of gelatin and bioactive glass. For in vitro analysis, adult human mesenchymal stem cells were seeded in the scaffolds. Material characterizations using hydrogen-1 nuclear magnetic resonance, in vitro degradation, as well as thermal and mechanical analysis showed that incorporation of PEDOT:PSS increased the physiochemical stability of the composite, resulting in improved mechanical properties and biodegradation resistance. The outcomes indicate that PEDOT:PSS and polypeptide chains have close interaction, most likely by forming salt bridges between arginine side chains and sulfonate groups. The morphology of the scaffolds and cultured human mesenchymal stem cells were observed and analyzed via scanning electron microscope, micro-computed tomography, and confocal fluorescent microscope. Increasing the concentration of the conductive polymer in the scaffold enhanced the cell viability, indicating the improved microstructure of the scaffolds or boosted electrical signaling among cells. These results show that these conductive scaffolds are not only structurally more favorable for bone tissue engineering, but also can be a step forward in combining the tissue engineering techniques with the method of enhancing the bone healing by electrical stimuli.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D conductive nanocomposite scaffold for bone tissue engineering

Shahini¹,

Yazdimamaghani²,

Walker³

et al. 2013

IJN

View full text Add to dashboard Cite

show abstract

“…While, the spectra from 1400 to 4000 cm -1 clearly consists of vibrations refer to water or hydroxyl groups [23]. The spectrum located at around 427 cm -1 is ascribed to the Si-O symmetric stretching of bridging oxygen atoms between tetrahedrons [24]. The spectrum at 468 cm -1 situated in the range 463 -498 cm -1 is attributed to Si-O-Si bending vibration mode [25].…”

Section: Resultsmentioning

confidence: 99%

Structure and Characterization of Some High Chemically Resistance Silicate Glasses

Abo-Mosallam¹

2016

Ceramics - Silikaty

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“…In related studies, Luz and Mano [78] have proposed a new composite membrane combining chitosan with sol-gel-derived BG nanoparticles based on both ternary (SiO 2 −CaO−P 2 O 5 ) and binary (SiO 2 −CaO) systems [78,79]. Mozafari et al [80] developed macroporous bioactive nanocomposite scaffolds using cross-linked gelatin and NBG through layer solvent casting combined with freeze-drying and lamination techniques. It was observed that NBG particles are dispersed evenly among cross-linked gelatin matrices.…”

Section: Natural Polymer/bioactive Glass Nanocompositesmentioning

confidence: 99%