Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

Abstract

Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core / gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ion on magnetic nanoparticle seeds. Hydrodynamic size and optical property of magneto-plasmonic nanoparticles synthesized with the variation of Au ion and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic property, and the magnetic property contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of magneto-plasmonic nanoparticles using an in vitro blood–brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

Size-selected Fe3O4–Au hybrid nanoparticles for improved magnetism-based theranostics

“…Biocompatible magnetite nanoparticles (NPs) are anticipated to provide new noninvasive therapies and early diagnostics for previously incurable diseases using a single, so-called “theranostics” platform [ 1 – 3 ]. The magnetic properties of Fe 3 O 4 NPs give rise to novel therapeutic approaches such as magneto-mechanical cancer treatment [ 4 ] and magnetic particle hyperthermia (MPH) [ 5 – 7 ] as well as to improvements in diagnostic techniques like magnetic resonance imaging (MRI) [ 8 – 10 ] and magnetic particle imaging (MPI) [ 11 – 12 ]. For advanced functionality under real operational conditions, various approaches have been attempted, e.g., optimization of the NP surface using targeting molecules or specific polymers [ 13 – 15 ].…”

Surface Plasmon Resonance (SPR) to Magneto-Optic SPR

“…One area where magneto-optics has been extensively studied is the localized magneto-optic SPR (LMO-SPR) functionality using magnetoplasmonics (magnetic-nonmagnetic) core-shell nano-particles, nano-rods, nano-antenna or nano-wires of dielectric and plasmonic materials [32]. These magnetoplasmonic structures have been considered for potential applications in drug delivery, drug detection, and biosensing, among many others.…”

Biomedical Nanotechnology Related Grand Challenges and Perspectives

“…f) Nanotechnology assisted combinational therapy is emerging as one of the best alternatives in conventional approaches. The approach optimizes a perfect combination of various therapeutic agents, therapeutic fabrication processes, and stimulations to treat multiple symptoms, at one time, while exploring the effects of various stimulations, exposures, drug-to-drug interactions, and drug/stimulation-human interactions in acute and chronic timelines (Figure 1; Kaushik et al, 2017a;Tomitaka et al, 2017Tomitaka et al, , 2019Jayant et al, 2018). g) The design and development of a new therapy is a wellplanned experiment.…”