Development of Matrix-Membrane Transdermal Drug Delivery System for Atenolol

Gupta, Sabnam; Sk, Jain

doi:10.1080/10717540490493943

Cited by 15 publications

(8 citation statements)

References 13 publications

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“…Active sam treatment was compared side-by-side with a nonactive device as a topical control. Strat-M Membrane (EMD Millipore, MA, USA) transdermal skin and an established experimental technique for concentration/penetration mapping through thirty 1-mm thick 32-mm diameter polyethylene oxide (PEO) (Hydress, Alliqua Biomedical, Inc., PA, USA) tissue hydrogel phantoms (n = 3) were used to mimic human tissue (human skin and tissue analog) [36,37]. PEO discs were stacked into a 30-mm pile and fitted into a polyurethane Franz-cell with a 32-mm diameter and 30-mm depth (Figure 3A).…”

Section: Testing Ultrasonic Coupling and Diathermy Profile Of The Sam Diclofenac Gel Patch Versus Commercial Gel Patchmentioning

confidence: 99%

Sustained Acoustic medicine; Sonophoresis for Nonsteroidal anti-inflammatory Drug Delivery in Arthritis

et al. 2020

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Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Materials & methods: A commercially available, sustained acoustic medicine (sam®) ultrasound device providing 4 h, 1.3 W, 132 mW/cm2, 3 MHz ultrasound treatment was evaluated for increasing the drug delivery of diclofenac gel through a human skin model and was compared with standard of care topical control diclofenac gel. Results: Sonophoresis of the diclofenac gel for 4 h increases diclofenac delivery by 3.8× (p < 0.01), and penetration by 32% (p < 0.01). Conclusion: Sustained acoustic medicine can be used as a transdermal drug-delivery device for nonsteroidal anti-inflammatory drugs.

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Section: Testing Ultrasonic Coupling and Diathermy Profile Of The Sam Diclofenac Gel Patch Versus Commercial Gel Patchmentioning

confidence: 99%

Sustained Acoustic medicine; Sonophoresis for Nonsteroidal anti-inflammatory Drug Delivery in Arthritis

et al. 2020

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“…Kim and Shin developed and studied the release of atenolol from the ethylene-vinyl acetate matrix containing various plasticizers. Many other study also developed increased release from topical formulation [12][13][14][15]. Hence, the objectives of this study were to formulate and investigate the physicochemical stability of atenolol in two different gel bases.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Stability Evaluation of Atenolol Gel in Two Different Bases

Chaerunisaa¹,

Mita²,

Rahmat³

2019

Asian J Pharm Clin Res

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Objective: The aim of the research about atenolol gel is to formulate and evaluate its stability in hydroxypropyl methylcellulose (HPMC) and Aqupec HV-505 gel base. Methods: Gels were formulated using Acupev HV-505 and HPMC at three different concentrations. Physicochemical evaluation and stability testing were performed including organoleptic examination, pH, viscosity, consistency, bleeding, qualitative analysis by thin-layer chromatography (TLC), and quantitative analysis by UV-visible spectrophotometry during 56 days of storage. Results: Physicochemical evaluation showed that the best formula was the one with 1% Aqupec HV-505 base (FA2). Further investigation was conducted by varying atenolol concentration to study the influence on gel stability. Evaluation on organoleptic performance, pH, viscosity, consistency, bleeding, microbiology, and qualitative and quantitative stability testing using TLC and UV-visible Spectrophotometry during 56 days of storage showed that the best gel formula was FA22, the one using 1% Aqupec HV-505 with 0.5% Atenolol The patch test showed that all atenolol gels were safe to be used. Conclusions: About 1% Aqupec HV-505 provided good physical properties and physicochemical stability to be used as gel base.

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“…Two different penetration enhancers Urea and Dimethyl sulphoxide (DMSO) were employed in the study. The dried polymeric film was evaluated using different parameters including thickness uniformity, drug content of the film, in vitro drug release from films and in vitro skin permeation of drug, prior to their in vivo evaluation [8,9].…”

Section: Introductionmentioning

confidence: 99%

Design, Formulation and Evaluation of Transdermal Drug Delivery System of Budesonide

Lade¹,

Amgaonkar²,

Chikhale³

et al. 2011

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Budesonide is a highly potent synthetic, nonhalogenated corticosteroid. The mechanism of action of corticosteroids in allergic rhinitis remains unknown, but may involve reductions in number of various mediator cells such as basophils, eosinophils, T-helper cells, mast cells, and neutrophils. In the nasal mucosa, nasal reactivity to allergens, and release of inflammatory mediators and proteolytic enzymes. Budesonide is very effective and quikly acting as it is rapidly and almost completely absorbed after oral administration, but has poor systemic availability (about 10%) due to extensive first-pass metabolism in the liver, mainly by the cytochrome P450 isoenzyme CYP3A4.. The major metabolites, 6-β- hydroxybudesonide and 16-α-hydroxyprednisolone have less than 1% of the glucocorticoid activity of unchanged drug with a terminal half-life of about 2 - 4 hours. Polymeric films containing Eudragit RL 100: Eudragit RS: drug (7:3:1, 7: 2:1) and Ethyl cellulose: PVP: drug (7:3:1, 7:2:1) were selected for transdermal administration based on evaluation studies. These polymeric films were prepared by mercury substrate method employing PEG-400 as plasticizer. Two different penetration enhancers Urea and Dimethyl sulphoxide (DMSO) were employed in the study. The patches in each group were uniform in drug content, thickness. In Vitro drug permeation, moisture absorption and WVTR studies were carried out on these test patches. It was found that at all humidity condition the absorption increases which were linear to the moisture absorbed. In PVA and EUDRAGIT RL 100 patches the water vapor transmission rate was found to be higher at 75% RH, RT conditions. Therefore at both % RH, RT condition the PVA and EUDRAGIT RL 100 patches provides the best resistance to water vapor. Therefore, when applied to animals (in further studies) these patches may provide more occlusion to water vapor loss from skin thus making atmosphere beneath the skin more humid that aid in drug permeation

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Development of Matrix-Membrane Transdermal Drug Delivery System for Atenolol

Cited by 15 publications

References 13 publications

Sustained Acoustic medicine; Sonophoresis for Nonsteroidal anti-inflammatory Drug Delivery in Arthritis

Sustained Acoustic medicine; Sonophoresis for Nonsteroidal anti-inflammatory Drug Delivery in Arthritis

Formulation and Stability Evaluation of Atenolol Gel in Two Different Bases

Design, Formulation and Evaluation of Transdermal Drug Delivery System of Budesonide

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