Development of Nano-Carbon Biosensors Using Glycan for Host Range Detection of Influenza Virus

Kawahara, Toshio; Hiramatsu, Hiroaki; Suzuki, Yasuo; Nakakita, Shin‐ichi; Ohno, Yasuhide; Maehashi, Kenzo; Matsumoto, Kazuhiko; Okamoto, Kazumasa; Matsuba, Teruaki; Utsunomiya, Risa

doi:10.3390/condmat1010007

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…Among them, energy-related applications are most common, primarily in supercapacitors [72,[83][84][85][86][87][88][89][90][91][92][93][94][95], but also in batteries [96][97][98][99][100][101][102][103][104][105][106], solar energy conversion [43,[107][108][109][110][111][112][113] and fuel cells [114][115][116][117][118]. Field emission [119][120][121][122][123][124] and molecule detection [125][126][127][128][129][13...…”

Section: Vertically Grown Graphene Nanostructures (Vg-gns)mentioning

confidence: 99%

Single-step growth of graphene and graphene-based nanostructures by plasma-enhanced chemical vapor deposition

et al. 2019

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The realization of many promising technological applications of graphene and graphenebased nanostructures depends on the availability of reliable, scalable, high-yield and low-cost synthesis methods. Plasma enhanced chemical vapor deposition (PECVD) has been a versatile technique for synthesizing many carbon-based materials, because PECVD provides a rich chemical environment, including a mixture of radicals, molecules and ions from hydrocarbon precursors, which enables graphene growth on a variety of material surfaces at lower temperatures and faster growth than typical thermal chemical vapor deposition (T-CVD). Here we review recent advances in the PECVD techniques for synthesis of various graphene and graphene-based nanostructures, including horizontal growth of monolayer and multilayer graphene sheets, vertical growth of graphene nanostructures (VG-GNs) such as graphene nanostripes (GNSPs) with large aspect ratios, direct and selective deposition of monolayer and multi-layer graphene on nanostructured substrates, and growth of multi-wall carbon nanotubes (MWCNTs). By properly controlling the gas environment of the plasma, it is found that no active heating is necessary for the PECVD growth processes, and that highyield growth can take place in a single step on a variety of surfaces, including metallic, semiconducting and insulating materials. Phenomenological understanding of the growth mechanisms are described. Finally, challenges and promising outlook for further development in the PECVD techniques for graphene-based applications are discussed.

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Section: Vertically Grown Graphene Nanostructures (Vg-gns)mentioning

confidence: 99%

Single-step growth of graphene and graphene-based nanostructures by plasma-enhanced chemical vapor deposition

et al. 2019

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“…Several sugar chains between 0.3 and 3.9 nm in height are present, and the spatial distribution of single molecules seems to be greater compared with sialoglycopolymer. 15) The long molecules of SGP possess flexibility, and hence the average spacial size of the molecules might be large. Furthermore, a wide distribution of the height of molecules can be observed in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…We have developed a biosensor using nano-carbon materials [12][13][14] which can identify the preferred host of the virus. 15,16) The host change can be observed as a change in the binding between viral protein and host sugar chains.…”

Section: Introductionmentioning

confidence: 99%

Effective binding of sugar chains to influenza virus on the surface by bovine serum albumin localization

Kawahara

Hiramatsu

Ohmi

et al. 2019

Jpn. J. Appl. Phys.

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The spread of influenza A virus variants requires continuous monitoring because of the high mutation rate. Given that the surveillance of such mutations is essential, the development and use of highly sensitive sensor systems is required. Host changes can manifest as changes in the binding between viral protein and host sugar chains. We employed sugar chains possessing different coordinations of terminal sialic acid and penultimate galactose groups as detection molecules. To enhance sensitivity, we developed an approach that controls the dispersion of molecules using bovine serum albumin (BSA) localization, and it was found that stable distribution was achieved. Several sugar chains were localized at fixed points on the BSA. The active sugar chain on BSA possessed suitable height as observed by atomic force microscopy. The clustering of sugar chains could also enhance the binding activity. Thus, we were able to enhance the sensitivity and availability of the detection of molecules.

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“…Nanocarbon tubes are a potential material with a greater affinity towards the modified biosensor. Nanocarbon-based biosensor modified by glycan has been used for the identification of influenza virus [ 123 , 124 ]. Nanocarbon resources have huge applications in the latest devices because of their high surface area and high mobility.…”

Section: Applicationmentioning

confidence: 99%

Nano-Structured Carbon: Its Synthesis from Renewable Agricultural Sources and Important Applications

et al. 2022

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Carbon materials are versatile in nature due to their unique and modifiable surface and ease of production. Nanostructured carbon materials are gaining importance due to their high surface area for application in the energy, biotechnology, biomedical, and environmental fields. According to their structures, carbon allotropes are classified as carbon nanodots, carbon nanoparticles, graphene, oxide, carbon nanotubes, and fullerenes. They are synthesized via several methods, including pyrolysis, microwave method, hydrothermal synthesis, and chemical vapor deposition, and the use of renewable and cheaper agricultural feedstocks and reactants is increasing for reducing cost and simplifying production. This review explores the nanostructured carbon detailed investigation of sources and their relevant reports. Many of the renewable sources are covered as focused here, such as sugar cane waste, pineapple, its solid biomass, rise husk, date palm, nicotine tabacum stems, lapsi seed stone, rubber-seed shell, coconut shell, and orange peels. The main focus of this work is on the various methods used to synthesize these carbon materials from agricultural waste materials, and their important applications for energy storage devices, optoelectronics, biosensors, and polymer coatings.

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Development of Nano-Carbon Biosensors Using Glycan for Host Range Detection of Influenza Virus

Cited by 7 publications

References 57 publications

Single-step growth of graphene and graphene-based nanostructures by plasma-enhanced chemical vapor deposition

Single-step growth of graphene and graphene-based nanostructures by plasma-enhanced chemical vapor deposition

Effective binding of sugar chains to influenza virus on the surface by bovine serum albumin localization

Nano-Structured Carbon: Its Synthesis from Renewable Agricultural Sources and Important Applications

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