Development of nanoclay-based nanocomposite surfaces with antibacterial properties for potential biomedical applications

Levana, Odelia; Jeong, Ji Hoon; Hur, Sung Sik; Seo, Wonbin; Noh, Kyung Mu; Hong, Soonkook; Park, Jae Hong; Lee, Ju Hun; Choi, Chulmin; Hwang, Yongsung

doi:10.1016/j.jiec.2022.12.052

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…Several surface modification and coating technologies have been developed to combat bacterial biofilm formation on abiotic surfaces. − Generally, these technologies can be grouped into two categories. , The first group, consisting of antibacterial coatings, contain materials such as peptides, metal nanoparticles, , and charged polymers , that inactivate bacterial cells that come into close proximity of the coated surfaces. Antibacterial efficacy can also be achieved through the strategic design of surface texture and topography. , Specifically, the incorporation of sharp nanofeatures has been reported to inactivate bacteria by inducing mechanical stresses and ruptures in bacterial cell membranes. − Namely, these mechano-bactericidal actions, mediated by precisely engineered sharp nanostructures, provide a physical means of bacterial inactivation .…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Superhydrophobic Nanocoating Based on Polydopamine and Nanodiamonds to Mitigate Bacterial Attachment to Polyvinyl Chloride Surfaces in Food Industry Environments

DeFlorio,

Zaza,

Arcot

et al. 2024

Ind. Eng. Chem. Res.

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Polyvinyl chloride (PVC) is commonly utilized as a food-contact surface by the food industry for processing and storage purposes due to its durability, ease of fabrication, and cost-effectiveness. Herein, we report a composite coating for the superhydrophobization of PVC without the use of polyfluoroalkyl chemistry. This coating rendered the PVC superhydrophobic, exhibiting a static water contact angle of 151.9 ± 0.7° and a contact angle hysteresis of only 3.1 ± 1.0°. The structure of this composite coating, consisting of polydopamine, nanodiamonds, and an alkyl silane, was investigated by utilizing both scanning electron microscopy and atomic force microscopy. Surface chemistry was probed using attenuated total reflectance-Fourier transform infrared, and the surface wetting behavior was thoroughly characterized using both static and dynamic water contact angle measurements. It was demonstrated that the superhydrophobic PVC was cleanable using a food-grade surfactant, becoming wet in contact with high concentration surfactant solutions, but regaining its nonwetting property upon rinsing with water. It was demonstrated that the coating produced a 2.1 ± 0.1 log10 reduction (99.2%) in the number of Escherichia coli O157:H7 cells and a 2.2 ± 0.1 log10 reduction (99.3%) in the number of Salmonella enterica Typhimurium cells that were able to adsorb onto PVC surfaces over a 24 h period. The use of this fluorine-free superhydrophobic coating on PVC equipment, such as conveyor belts within food production facilities, may help to mitigate bacterial cross-contamination and curb the spread of foodborne illnesses.

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Section: Introductionmentioning

confidence: 99%

Bioinspired Superhydrophobic Nanocoating Based on Polydopamine and Nanodiamonds to Mitigate Bacterial Attachment to Polyvinyl Chloride Surfaces in Food Industry Environments

DeFlorio,

Zaza,

Arcot

et al. 2024

Ind. Eng. Chem. Res.

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“…To address these challenges, researchers have been exploring the potential of nanocomposites to enhance the performance of medical implants [4,5]. Nanocomposites are materials composed of nanoparticles or nanofillers dispersed in a matrix material, such as a polymer or metal [6].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Enhancing the Performance of Medical Implants with Nanocomposites

Ramezani

Ripin

2023

J. Compos. Sci.

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Medical implants are essential tools for treating chronic illnesses, restoring physical function, and improving the quality of life for millions of patients worldwide. However, implant failures due to infection, mechanical wear, corrosion, and tissue rejection continue to be a major challenge. Nanocomposites, composed of nanoparticles or nanofillers dispersed in a matrix material, have shown promising results in enhancing implant performance. This paper provides an overview of the current state of research on the use of nanocomposites for medical implants. We discuss the types of nanocomposites being developed, including polymer-, metal-, and ceramic-based materials, and their advantages/disadvantages for medical implant applications. Strategies for improving implant performance using nanocomposites, such as improving biocompatibility and mechanical properties and reducing wear and corrosion, are also examined. Challenges to the widespread use of nanocomposites in medical implants are discussed, such as biocompatibility, toxicity, long-term stability, standardisation, and quality control. Finally, we discuss future directions for research, including the use of advanced fabrication techniques and the development of novel nanocomposite materials. The use of nanocomposites in medical implants has the potential to improve patient outcomes and advance healthcare, but continued research and development will be required to overcome the challenges associated with their use.

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“…1 However, the subsequent microbial invasion and biofilm adhesion on implant surfaces are the root causes of surgical site infections. 2 According to the World Health Organization (WHO) report, 50% of infections are due to surgical site infections. 3 Biofilms developed on biomaterial implant surfaces are difficult to eradicate with antibiotics, requiring surgical debridement and reoperation in the worst scenario.…”

Section: Introductionmentioning

confidence: 99%

“…Under various chronic conditions, biomaterial-based implants have proved to be a lifesaving technique . However, the subsequent microbial invasion and biofilm adhesion on implant surfaces are the root causes of surgical site infections . According to the World Health Organization (WHO) report, 50% of infections are due to surgical site infections .…”

Section: Introductionmentioning

confidence: 99%

Amination of Polyurethane for Designing Infection-Resistant Surfaces

Somani,

Mukhopadhyay,

Gupta

2023

Ind. Eng. Chem. Res.

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Polyurethane (PU) has emerged as a promising class of polymeric material for biomedical applications due to its outstanding physicochemical properties. However, the resulting immune response and on-site infections are unavoidable consequences of PU-based implants. Immobilizing bioactive agents and biopolymers is an excellent approach to overcome these issues. However, the inherent inertness and hydrophobicity of PU create restraint on the immobilization of bioactive agents on its surface. In this work, a PU film was subjected to aminolysis using ethylene diamine (EDA) under varied temperatures, time, and EDA concentrations. The influence of reaction parameters on the formation of free amino (−NH 2 ) groups and the resulting changes in the physicochemical properties of PU were investigated further. The optimized amine content was ∼0.08 μM/cm 2 after treatment with 10% EDA for 15 min. The surface was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle measurement. Ciprofloxacin was used as a prototype drug and was immobilized by the dip-coating approach on the functionalized PU surface. The drug-immobilized PU showed excellent antibacterial and antibiofouling efficacy against both Gram-positive and Gram-negative bacteria.

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Development of nanoclay-based nanocomposite surfaces with antibacterial properties for potential biomedical applications

Cited by 9 publications

References 45 publications

Bioinspired Superhydrophobic Nanocoating Based on Polydopamine and Nanodiamonds to Mitigate Bacterial Attachment to Polyvinyl Chloride Surfaces in Food Industry Environments

Bioinspired Superhydrophobic Nanocoating Based on Polydopamine and Nanodiamonds to Mitigate Bacterial Attachment to Polyvinyl Chloride Surfaces in Food Industry Environments

An Overview of Enhancing the Performance of Medical Implants with Nanocomposites

Amination of Polyurethane for Designing Infection-Resistant Surfaces

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