2010
DOI: 10.3807/josk.2010.14.2.065
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Development of Nanostructured Plasmonic Substrates for Enhanced Optical Biosensing

Abstract: Plasmonic-based biosensing technologies have been successfully commercialized and applied for monitoring various biomolecular interactions occurring at a sensor surface. In particular, the recent advances in nanofabrication methods and nanoparticle syntheses provide a new route to overcome the limitations of a conventional surface plasmon resonance biosensor, such as detection limit, sensitivity, selectivity, and throughput. In this paper, optical and physical properties of plasmonic nanostructures and their c… Show more

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Cited by 39 publications
(27 citation statements)
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“…This peak represents the localized surface plasmon resonance (LSPR) peak of the silver nanoparticles [32]. LSPR is the collective electron charge oscillation in metallic nanoparticles excited by electromagnetic waves [33]. Figure 4(c) and (d) show the simulation results for intensity distribution of a copper particle with the same diameter of 10 nm at wavelengths of 355 nm and 532 nm, respectively.…”
Section: Melting Temperature and Surface Melting Temperaturementioning
confidence: 94%
“…This peak represents the localized surface plasmon resonance (LSPR) peak of the silver nanoparticles [32]. LSPR is the collective electron charge oscillation in metallic nanoparticles excited by electromagnetic waves [33]. Figure 4(c) and (d) show the simulation results for intensity distribution of a copper particle with the same diameter of 10 nm at wavelengths of 355 nm and 532 nm, respectively.…”
Section: Melting Temperature and Surface Melting Temperaturementioning
confidence: 94%
“…Sensing of these small molecules in complex matrices poses a challenge because of high mass molecules such as proteins interfering with target molecules in small quantities [144]. Using labeled nanoparticles increases the local dielectric constant and also can introduce plasmonic coupling (as stated above) resulting in higher sensitivity to smaller target biomolecules [144][145][146][147][148][149][150][151]. As shown in Figure 7, the silver nanoparticle-based LSPR biotin biosensor responds with a very large change upon attachment of biotin-labeled gold nanoparticles.…”
Section: Sensitivity Improvement Of Lsprmentioning
confidence: 99%
“…Although Insulator-Metal-Insulator (IMI) waveguides have the advantage of less loss for the longer propagation distance, but their light confinement capability into subwavelength scales is poor [18]. Numerous functional plasmonic MIM structures like directional couplers [19], filters [20], Y-shaped combiners [21], sensors [22], U-shaped waveguides [23], Bragg reflectors [24], etc, have been numerically and/or experimentally investigated.…”
Section: Introductionmentioning
confidence: 99%