Development of nanotheranostics against metastatic breast cancer — A focus on the biology &amp; mechanistic approaches

Subramanian, Anuradha; Manigandan, Amrutha; Sivashankari, P. R.; Sethuraman, Swaminathan

doi:10.1016/j.biotechadv.2015.10.002

Cited by 18 publications

(9 citation statements)

References 141 publications

(141 reference statements)

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“…4T1 cells can metastasize even at an early stage, primarily to the lung and liver. 58,59 The lungs and livers isolated from normal and tumor-bearing mice were fixed and stained with H&E. The results of histopathological examination are demonstrated in Figure 11. In the saline and blank LCS_NPs group, large areas of the metastatic region were observed in the lungs and livers (red circles and arrows) instead of normal physiological structures, which suggested significant tumor micrometastasis in these two groups.…”

Section: Influence Of Ptx-ch-loaded Lcs_nps On Cell Apoptosismentioning

confidence: 99%

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex</p>

Chu¹,

Huang

Wang³

et al. 2019

IJN

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BackgroundIntratumoral injection is a palliative treatment that aims at further improvement in the survival and quality of life of patients with advanced or recurrent carcinomas, or cancer patients with severe comorbidities or those with a poor performance status.MethodsIn this study, a solvent-injection method was used to prepare paclitaxel–cholesterol complex-loaded lecithin–chitosan nanoparticles (PTX-CH-loaded LCS_NPs) for intratumoral injection therapy, and the physicochemical properties of NPs were well characterized.ResultsThe particle size and zeta potential of PTX-CH-loaded LCS_NPs were 142.83±0.25 nm and 13.50±0.20 mV, respectively. Release behavior of PTX from PTX-CH-loaded LCS_NPs showed a pH-sensitive pattern. The result of cell uptake assay showed that PTX-CH-loaded LCS_NPs could effectively enter cells via the energy-dependent caveolae-mediated endocytosis and macropinocytosis in company with the Golgi apparatus. Meanwhile, PTX-CH-loaded LCS_NPs had a better ability to induce cell apoptosis than PTX solution. The in vivo antitumor results suggested that PTX-CH-loaded LCS_NPs effectively inhibited mouse mammary cancer growth and metastasis to distant organs and significantly improved the survival rate of tumor-bearing mice by intratumoral administration.ConclusionIn general, our study demonstrated that PTX-CH-loaded LCS_NPs used for palliative treatment by intratumoral injection showed improved safety and antitumor efficacy, which provided an alternative approach in the field of palliative chemotherapy.

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Section: Influence Of Ptx-ch-loaded Lcs_nps On Cell Apoptosismentioning

confidence: 99%

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex</p>

Chu¹,

Huang

Wang³

et al. 2019

IJN

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“…Especially in solid tumor tissues, the substantial energy requirement for their intensive growth results in increased lactate and hydrogen ions (H + ) produced by catabolism of glucose. Consequently, the tumor microenvironment becomes acidic with a pH ~6.5 in tumor tissues versus pH ~7.4 in normal tissues 57 , 61 - 63 . This difference can then be exploited for targeting the tumor tissue or triggering drug release in the tumor's extracellular matrix 60 , 64 - 68 .…”

Section: Introductionmentioning

confidence: 99%

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

et al. 2018

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Nanotechnology-based antitumor drug delivery systems, known as nanocarriers, have demonstrated their efficacy in recent years. Typically, the size of the nanocarriers is around 100 nm. It is imperative to achieve an optimum size of these nanocarriers which must be designed uniquely for each type of delivery process. For pH-responsive nanocarriers with programmable size, changes in pH (~6.5 for tumor tissue, ~5.5 for endosomes, and ~5.0 for lysosomes) may serve as an endogenous stimulus improving the safety and therapeutic efficacy of antitumor drugs. This review focuses on current advanced pH-responsive nanocarriers with programmable size changes for anticancer drug delivery. In particular, pH-responsive mechanisms for nanocarrier retention at tumor sites, size reduction for penetrating into tumor parenchyma, escaping from endo/lysosomes, and swelling or disassembly for drug release will be highlighted. Additional trends and challenges of employing these nanocarriers in future clinical applications are also addressed.

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“…Specifically, a solution of ND and NP increased the percentages of T-lymphocytes CD4 + and CD8 + of aged mice, which may be useful for preventing immune dysfunction [21]. Previous studies that have investigated the effects of DPV576 on cancer cells have shown that this solution of ND and NP is an effective tool for fighting cancer cells [22–24]. Although the toxicity of nanomaterial is dose- and time-dependent [25], we are not aware of any published studies that have shown the nanomaterial used in the Venex textile is toxic to humans or animals.…”

Section: Introductionmentioning

confidence: 99%

Influence of platinum harmonized textile on neuromuscular, systemic and subjective recovery

2017

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The clothing manufacturer Venex Life-Science tracks the strategy to enhance recovery process through implementing platinum harmonized technology (PHT) into their Venex® Regeneration Wear. The proposed mechanisms of the regeneration wear are an increase of parasympathetic activity and an increase of the temperature due far-infrared radiation. The purpose of this study was to investigate potential effects of Venex regeneration wear on the recovery of neuromuscular, systemic and subjective parameters following exercise. In a randomized, single-blinded cross-over design, 13 strength-trained male participants performed two exercise sessions in one day. After the first exercise session and for 3 nights following the exercise day participants wore the Venex regeneration wear or a placebo product. Measures of isometric maximum voluntary contraction (MVC), voluntary activation (VA) and potentiated twitch torque (PTT) of the knee extensors, as well as maximum jump height during the Counter-Movement and Drop Jump, creatinkinase (CK) and subjective parameters (perceived pain, recovery condition and sleep quality) were obtained before and after each exercise session and 24, 48, and 72 hours after the first exercise session. MVC, PTT, CK and jump parameters changed over time during the exercise day as well as on the following days, however, there were no significant differences between treatments. Subjective parameters showed strong effect sizes (i. e. Cohen’s d > 0.6) in favor for Venex but no significant differences between treatments. Based on these findings, it is concluded that wearing a platinum harmonized textile following exercise did not improve neuromuscular and systemic recovery in a trained male population to a statistical noticeable extent. However, the findings for the subjective parameters suggest some potential for enhanced recovery that requires further research.

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Development of nanotheranostics against metastatic breast cancer — A focus on the biology & mechanistic approaches

Cited by 18 publications

References 141 publications

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex</p>

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex</p>

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

Influence of platinum harmonized textile on neuromuscular, systemic and subjective recovery

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Development of nanotheranostics against metastatic breast cancer — A focus on the biology & mechanistic approaches

Cited by 18 publications

References 141 publications

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin&ndash;chitosan nanoparticles loading paclitaxel&ndash;cholesterol complex</p>

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin&ndash;chitosan nanoparticles loading paclitaxel&ndash;cholesterol complex</p>

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

Influence of platinum harmonized textile on neuromuscular, systemic and subjective recovery

Contact Info

Product

Resources

About

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex</p>

<p>Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex</p>