Development of nanovesicular systems for dermal imiquimod delivery: physicochemical characterization and in vitro/in vivo evaluation

Ma, Man; Wang, Jinping; Guo, Fang; Liu, Ming; Tan, Fengping; Li, Nan

doi:10.1007/s10856-015-5524-1

Cited by 50 publications

(38 citation statements)

References 50 publications

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“…Many researchers have reported superior properties of transethosomes over classical ethosomes. [17][18][19][20][21][22][23][24][25][26][27][28][29][30] Different types of edge activators and penetration enhancers have been investigated to produce ethosomal systems with better characteristics. Transethosomes were reported to entrap drugs with molecular weights ranging from 130.077 Da to 200-325 kDa.…”

Section: Transethosomesmentioning

confidence: 99%

“…17,25,29 Song et al used oleic acid as a penetration enhancer at a concentration of 0.5% and found that transethosomes of voriconazole containing oleic acid were smaller and more elastic than transethosomes containing Tween 80 or sodium taurocholate. Moreover, the transethosomes containing oleic acid had higher negative ζ-potential, skin-permeation rate, and drug disposition in the epidermis/dermis.…”

Section: Oleic Acidmentioning

confidence: 99%

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Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

327

215

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Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems.

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Section: Transethosomesmentioning

confidence: 99%

Section: Oleic Acidmentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

327

215

View full text Add to dashboard Cite

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“…TE was made by thin layer hydration method referred to Ma et al [4] with slight modification. Lipoid P30 and Span 80 were dissolved in dichloromethane.…”

Section: Preparation Of Transethosomesmentioning

confidence: 99%

“…TE is composed of phospholipids, ethanol, edge activators (surfactants) and penetration enhancers. High elasticity of TE is influenced by a combination of ethanol and edge activator [3,4]. Also, it has been used for chemical substances or natural products.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Stability Tformulation, Stability Test and in Vitro Penetration Study of Transethosomal Gel Containing Green Tea (Camellia Sinensis L. Kuntze) Leaves Extractest and in Vitro Penetration Study of Transethosomal Gel Containing Green Tea(camellia Sinensis L. Kuntze) Leaves Extract

2017

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Objective: The aim of this study was to increase penetration of epigallocatechin gallate (EGCG) from the extract using transethosomal gel.Methods: Transethosomes (TE) formulae were made using thin layer hydration method with different concentration of green tea extract which was equivalent to 1% (F1), 1.5% (F2), and 2% (F3) of EGCG. F1 was the chosen formula to be incorporated into a gel as a transethosomal gel (TEG). A gel containing green tea extract was also made as a control called as non-transethosomal gel (NTEG). A stability test and in vitro penetration study of gels using Franz diffusion cell were performed.Results: F1 was the chosen formula because it had a spherical shape, a particle size of 112.14±2.19 nm, PDI of 0.166±0.03, a zeta potential of-52.05±1.34 mV, and %EE of 58.06±0.08%. Stability test results showed that TEG more stable than NTEG. The amount of EGCG penetrated from TEG and NTEG were 1391.16±34.89 µg/cm 2 and 485.29±14.49 µg/cm 2 , respectively (p<0.05). The lag time for TEG was around 0.99±0.2 h, while NTEG was 8.69±0.2 h (p<0.05). Conclusion:It can be concluded that transethosomes can improve gel stability and increase the amount of EGCG penetrated through the skin.

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“…The direct method does not require a heating process and therefore can be used with thermolabile compounds. In addition, in 2015, Man Ma undertook a transethosome production project that utilized the thin layer method and developed a vesicle with good entrapment and spherical shape [6,7]. This study seeks to determine which method is best by studying transethosome vesicles.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Penetration Tests of Transethosome Gel Preparations Containing Capsaicin

2017

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Objective: Capsaicin is an active compound found in chili pepper and has been shown to have analgesic, antioxidant, anticancer, and anti-obesity properties. To improve its penetration into the skin, capsaicin was prepared in a transethosome vesicle. Importantly, transethosomes are vesicles that consist of phosphatidylcholine, surfactant, and ethanol. In this study, capsaicin was prepared in a transethosome vesicle using two different methods: Direct transethosome formation and thin layer hydration. The aims of this study were to determine the effects of various methods of transethosome formation on capsaicin characteristics and to evaluate the penetration capabilities of transethosome capsaicin gel.Methods: Ultimately, transethosome formation via the thin layer method yielded more favorable characteristics; these formations had particle sizes of 174.9±2.02 nm and an entrapment efficiency of 84.85±1.15%. The transethosome suspension was then developed into a gel formulation using 1% carbomer. An in vitro penetration test was performed using a Franz diffusion cell of mice abdomen skin, and the performance of the transethosome capsaicin gel was compared to that of the standard capsaicin gel.Results: Penetration rate of capsaicin from either the transethosome gel preparation and the standard gel substance was 1549.68±49.6 and 846.05±10.1 µg/cm 2 , respectively. Conclusions:According to these results, it can be concluded that gel preparations containing transethosome increase capsaicin penetration into the skin.

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Development of nanovesicular systems for dermal imiquimod delivery: physicochemical characterization and in vitro/in vivo evaluation

Cited by 50 publications

References 50 publications

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Formulation, Stability Tformulation, Stability Test and in Vitro Penetration Study of Transethosomal Gel Containing Green Tea (Camellia Sinensis L. Kuntze) Leaves Extractest and in Vitro Penetration Study of Transethosomal Gel Containing Green Tea(camellia Sinensis L. Kuntze) Leaves Extract

In Vitro Penetration Tests of Transethosome Gel Preparations Containing Capsaicin

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