Development of neuropeptide Y-containing neurons in sympathetic ganglia of rats

Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

“…NPY was revealed in the intramural ganglia of the atria and stellate ganglia at all age periods (beginning from birth). The percentage of NPY-containing neurons in autonomic nervous ganglia increases during early postnatal ontogeny [4].NPY plays a role in the regulation of various physiological processes. This peptide produces a variety of central effects, including hypotension, hypothermia, and inhibition of respiration [2].…”

“…NPY was revealed in the intramural ganglia of the atria and stellate ganglia at all age periods (beginning from birth). The percentage of NPY-containing neurons in autonomic nervous ganglia increases during early postnatal ontogeny [4].…”

Development of neuropeptide Y-mediated heart innervation in rats

“…The density of NPY-positive fibers increases in the first 20 days of rats' life. An increase of NPY-IR sympathetic ganglionic neurons is observed at the same period (Maslyukov et al 2007(Maslyukov et al , 2010Masliukov et al 2012;Masliukov and Nozdrachev 2013).…”

“…In the heart, the most prominent source of NPY is postganglionic sympathetic fibers, the majority originating from neurons located in the stellate ganglion (Richardson et al 2006;Masliukov et al 2012). In rodents, NPY is also expressed by the parasympathetic neurons of the intrinsic cardiac ganglia (Richardson et al 2003).…”

“…The expression of the spectrum of neurotransmitters in autonomic ganglionic neurons is subject to changes during pre-and postnatal development (Apostolova and Dechant, 2009;Young et al 2011;Masliukov et al 2012Masliukov et al , 2015. Sympathetic NPY-immunoreactive (IR) nerve fibers show the earliest expression by 16 days of rat gestation in myocardium (Shoba and Tay 2000).…”