Development of Non-Enzymatic Glucose Biosensors Based on Electrochemically Prepared Polypyrrole-Chitosan-Titanium Dioxide Nanocomposite Films

Abstract

Abstract:The performance of modified electrode of nanocomposite film consisting of polypyrrolechitosan-titanium dioxide (Ppy-CS-TiO2) has been explored as non-enzymatic glucose biosensors. The synergy effect of TiO2 nanoparticles and conducting polymer on the current response of electrode resulted in higher sensitivity for nanocomposite modified electrode. The incorporation of TiO2 nanoparticles in the nanocomposite films were confirmed by XPS spectra. The FESEM and HR-TEM provided more evidences for the presence of TiO2 in Ppy-CS structure. Glucose biosensing properties were determined by amperommetry and cyclic voltammetry (CV) methods. The interfacial properties of nanocomposite electrodes were studied by electrochemical impedance spectroscopy (EIS). The developed biosensors showed a good sensitivity over the liner range of 1-14 mM with a detection limit of 614 μM for glucose. It also exhibited good selectivity and long term stability with no interference effect. The Ppy-CS-TiO2 nanocomposites film presented high electron transfer kinetics.

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

“…However, the unaffordable cost of these metals for the development of NEG sensors has limited their use. Consequently, researchers have commenced designing NEG sensors based on metals and their oxides, and in particular, the focus was given to Ni ( Rajendran et al, 2018 ), Zn ( Yang et al, 2016a ; Ognjanović et al, 2019 ), Cu ( Shabnam et al, 2017 ), NiO ( Baghayeri et al, 2018b ), CuO ( Shabnam et al, 2017 ), NiCo 2 O 4 ( Baghayeri et al, 2018b ; Rajendran et al, 2018 ), Fe ( Li et al, 2015 ; Marie et al, 2018 ), Mn ( Li et al, 2015 ; Xie et al, 2018a ), Ti ( AL-Mokaram et al, 2017 ), Ir ( Dong et al, 2018a ; Dong et al, 2019 ), and Rh ( Dong et al, 2018b ) etc.…”

Non-Enzymatic Glucose Biosensor Based on Highly Pure TiO2 Nanoparticles

“…Among the metal oxide NPs in particular especially, the interest for titanium dioxide (TiO 2 ) NP is being amplified due to its unique properties such as high surface area and high catalytic efficiency, which can improve the interaction between biomolecules and electrode surfaces [ 29 , 30 , 31 , 32 , 33 ]. Recently, a glucose sensor using a nanocomposite film of polypyrrole–chitosan–TiO 2 with a detection limit of 614 µM has been reported [ 34 ].…”

Disposable Amperometric Biosensor Based on Poly‐L‐lysine and Fe3O4 NPs‐chitosan Composite for the Detection of Tyramine in Cheese

“…To date, various polymer and Fe 3 O 4 NP composites such as polypyrrole/Fe 3 O 4 NP , Fe 3 O 4 NP/chitosan‐g‐polyaniline , Fe 3 O 4 NP‐polyvinyl alcohol have been investigated. The main goal of these approaches is to improve the sensing capabilities of sensor and biosensors, such as sensitivity, operational stability, reproducibility, selectivity and long‐term stability.…”