Development of non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials

Hori, Takao; Nagase, Takeshi; Todai, Mitsuharu; Matsugaki, Aira; Nakano, Takayoshi

doi:10.1016/j.scriptamat.2019.07.011

Cited by 159 publications

(74 citation statements)

References 17 publications

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“…Even if one of the studies concluded that obtuse-angled pores had a better influence on cell proliferation [93], there is still no reliable evidence to confirm that pore geometry is a defining characteristic for the osteoconduction and osteoinduction of the SLM-fabricated Ti scaffolds. Besides Ti and its alloys, recent progresses in novel materials have been made, such as equiatomic, non-equiatomic Ti-Nb-Ta-Zr-Mo either Ti-15Mo-5Zr-3Al materials for biomedical purpose [109][110][111][112]. The authors showed that the implied chemical substances and their arrangement show superior mechanical properties and biocompatibility compared to Ti 6 Al 4 V. Moreover, the use of β-Ti alloys allows the manufacture of low Young modulus scaffolds, which are similar to bone properties [113].…”

Section: Discussionmentioning

confidence: 99%

Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

Băbțan

Timuș

Şoriţău

et al. 2020

Metals

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Background: SLM (Selective Laser Melting)–manufactured Titanium (Ti) scaffolds have a significant value for bone reconstructions in the oral and maxillofacial surgery field. While their mechanical properties and biocompatibility have been analysed, there is still no adequate information regarding tissue integration. Therefore, the aim of this study is a comprehensive systematic assessment of the essential parameters (porosity, pore dimension, surface treatment, shape) required to provide the long-term performance of Ti SLM medical implants. Materials and methods: A systematic literature search was conducted via electronic databases PubMed, Medline and Cochrane, using a selection of relevant search MeSH terms. The literature review was conducted using the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Results: Within the total of 11 in vitro design studies, 9 in vivo studies, and 4 that had both in vitro and in vivo designs, the results indicated that SLM-generated Ti scaffolds presented no cytotoxicity, their tissue integration being assured by pore dimensions of 400 to 600 µm, high porosity (75–88%), hydroxyapatite or SiO2–TiO2 coating, and bioactive treatment. The shape of the scaffold did not seem to have significant importance. Conclusions: The SLM technique used to fabricate the implants offers exceptional control over the structure of the base. It is anticipated that with this technique, and a better understanding of the physical interaction between the scaffold and bone tissue, porous bases can be tailored to optimize the graft’s integrative and mechanical properties in order to obtain structures able to sustain osseous tissue on Ti.

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Section: Discussionmentioning

confidence: 99%

Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

Băbțan

Timuș

Şoriţău

et al. 2020

Metals

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“…They observed dense osteoblasts (help in bone matrix formation) with widespread morphology on the surfaces of the as‐cast and annealed TiNbTaZrMo, similar to the morphology of the cells on commercially pure (CP) Ti, suggesting analogous biocompatibility between novel RHEAs and CP Ti. Since then, several biocompatibility studies of RHEAs [ 79–85 ] have been reported, which is beyond the scope of our Review. In designing HEAs, unusual elements and microstructure combinations can be made as long as the chosen elements meet the phase formation requirements.…”

Section: Four Core Effects and Phase Formation Rulesmentioning

confidence: 99%

Phase Selection, Lattice Distortions, and Mechanical Properties in High‐Entropy Alloys

et al. 2020

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Increasing demand for improved physical, chemical, and mechanical properties led to the development of conventional alloys from single elements. These conventional alloys are made by selecting one or two major elements with desired properties, and other minor components are added to tune the properties to meet performance specifications. The conventional alloy design strategy is mainly based on the "solutesolvent" principle. However, another alloy design strategy based on multiprincipal elements in the near-equimolar ratio has recently been developed. In this multiprincipal element system, it is difficult to distinguish between the solute and the solvent, and various atoms are supposed to be randomly distributed in the crystal lattices (which has not been confirmed yet). This strategy, proposed by Yeh [1] and Cantor, [2] was based on the Boltzmann hypothesis of the relationship between entropy and system complexity. They proposed that the increased configurational entropy of mixing in alloys with multiple alloying elements in near-equiatomic proportions would overcome the enthalpy of compound formation, stabilizing solid solutions (SS) at the expense of intermetallics (IMs) during solidification. These multiprincipal element alloys are named "high entropy alloys" (HEAs), although the exact values of entropy in HEAs have not been experimentally measured yet. Since then, hundreds of HEAs with different combinations have been developed based on transition metals, refractory metals, and compound forming elements. [2-20] Most of these HEAs have been found to possess simple crystal structures such as the face-centered cubic (fcc) Fe-Co-Cr-Mn-Ni HEAs, [2] bodycentered cubic (bcc) Al-Co-Cr-Fe-Ni HEAs, [18] and the hexagonal close-pack (hcp) Ho-Dy-Y-Gd-Tb HEAs [6] when solidified from the melts. Experimental characterization techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), nanoindentation, tensile, wear-and corrosionresistance tests have been used to study the microstructureproperties correlations of HEAs. [3-50] These studies have revealed that HEAs possess superior properties, such as high hardness and strength, [23-29] superior corrosion and wear resistance, [3,30-35] good magnetic properties, [9,36-39,51] structural stability, [7,40,41] attractive mechanical properties at extreme temperature conditions, [21,42-47] and good electronic properties. [48,49] Yeh [50] proposed four core effects of HEAs, namely: 1) high-entropy effect; 2) sluggish diffusion effect; 3) sever lattice distortion effect; and 4) cocktail effect, in which the lattice distortion might be the key factor affecting the properties of HEAs. Although a complete understanding of lattice distortions in HEAs is still not established yet, significant progress in HEAs has been made recently.

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“…In order to evaluate the adhesion effect of osteoblasts on the surface of HEA immunocytochemical methods were used to observe the cell adhesion behavior. Hori et al (2019) FIGURE 9 | (A) Schematic illustration for the antimicrobial mechanism of AHEA, (B) polarization curves of 304 SS, 304 Cu-SS, and AHEA in the simulated seawater and (C) yield stresses and antibacterial rates (Zhou et al, 2020). Reproduced from Zhou et al (2020) with permission.…”

Section: Cell Adhesion and Cytotoxicity Assaymentioning

confidence: 99%

“…The osteoblasts on the as-cast and annealed FIGURE 10 | Biocompatibility of the ingots of bio-HEAs. (A) Giemsa staining images of osteoblasts on the fabricated specimens of SUS316L (stainless steel), CP-Ti (commercial pure titanium), and Ti 1.4 Zr 1.4 Nb 0.6 Ta 0.6 Mo 0.6 , (B) fluorescent images of osteoblast adhesion on the fabricated specimens of SUS316, CP-Ti, equiatomic TiNbTaZrMo, and non-equiatomic Ti 2−x Zr 2−x Nb x Ta x Mo x (x = 0.6, 1.4) bio-HEAs, and (C) quantitative analysis of size regulation of fibrillar adhesions (longer than 5 µm) in osteoblasts cultured on the fabricated specimens (Hori et al, 2019). Reproduced from Hori et al (2019) with permission.…”

Section: Cell Adhesion and Cytotoxicity Assaymentioning

confidence: 99%

Research Progress of Titanium-Based High Entropy Alloy: Methods, Properties, and Applications

Liu

et al. 2020

Front. Bioeng. Biotechnol.

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With the continuous progress and development in the biomedicine field, metallic biomedical materials have attracted the considerable attention of researchers, but the related procedures need to be further developed. Since the traditional metal implant materials are not highly compatible with the human body, the modern materials with excellent mechanical properties and proper biocompatibility should be developed urgently in order to solve any adverse reactions caused by the long-term implantations. The advent of the high-entropy alloy (HEA) as an innovative and advanced idea emerged to develop the medical implant materials through the specific HEA designs. The properties of these HEA materials can be predicted and regulated. In this paper, the progression and application of titanium-based HEAs, as well as their preparation and biological evaluation methods, are comprehensively reviewed. Additionally, the prospects for the development and use of these alloys in implant applications are put forward.

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Development of non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials

Cited by 159 publications

References 17 publications

Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

Phase Selection, Lattice Distortions, and Mechanical Properties in High‐Entropy Alloys

Research Progress of Titanium-Based High Entropy Alloy: Methods, Properties, and Applications

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