Development of non-leaching and eco-friendly polyhexamethylene guanidine hydrochloride based antimicrobial waterborne polyacrylates

Abstract

Purpose The purpose of this paper is to develop non-leaching and eco-friendly antimicrobial waterborne polyacrylates with excellent antibacterial properties by grafting antibacterial vinyl monomer, glycidyl methacrylate (GMA) modified polyhexamethylene guanidine hydrochloride (PHMG). Design/methodology/approach PHMG of different molecular weights were modified by GMA to synthesize antibacterial vinyl monomer, GMA-modified PHMG (GPHMG). Different content and molecular weights of GPHMG were used to synthesize antimicrobial waterborne polyacrylates through emulsion polymerization. Findings The addition of GPHMG gained by modifying PHMG showed little influence on thermal stability of the films, but decreased the glass transition temperature(Tg). Meanwhile, the tensile strength decreased, while the breaking elongation increased. The antibacterial properties of the antibacterial films with different GPHMG contents were studied, when GPHMG content was around 0.9 Wt.%, antibacterial films showed excellent antibacterial activity (antibacterial rate >= 99.99 per cent). When weight content of GPHMG in the films remained constant, antibacterial property of films increased first and then decreased with the increase of molecular weight of GPHMG. The structural antibacterial polymer film had more perdurable antibacterial activity than the blended one. Research limitations/implications The grafting efficiency of GPHMG to antimicrobial waterborne polyacrylates could be further improved. Practical implications Antimicrobial waterborne polyacrylates with excellent antibacterial properties can be used to antibacterial coating and adhesive. Originality/value The antibacterial properties of films with different molecular weight of GPHMG were studied, and the durability and stability of antibacterial properties between structural antimicrobial films and blended antimicrobial films were also investigated by ring-diffusion method.

Mechanical, antibacterial, biocompatible and microleakage evaluation of glass ionomer cement modified by nanohydroxyapatite/polyhexamethylene biguanide

“…The leach property of sterilizing agents from materials is an important issue, as it can affect the antimicrobial sustainability and short-term cytotoxicity in vivo. Compared with the small molecular antibacterial agent, that with high molecules, such as PHMB, is not easy to be leached and have more durable antibacterial properties as well as no pollution 50,51) . Moreover, PHMB is a kind of biocidal polymers 52) , eliminating microbes with nonspecific mechanism bodily rather than biocide-releasing polymers and polymeric biocides 52) , in which the polymers themselves are in essence only used as carriers connecting small molecular antibacterial agents.…”

The use of polyhexamethyleneguanidine as a modern disinfectant

“…Резистентності мікрофлори до солей полігексаметиленгуанідину незазначено. Засоби володіють пролонгованою дією та діють за умови зміни рН, мають тривале зберігання і стабільні при транспортуванні, підлягають застосуванню різним способом (обприскування, зрошення, протирання, занурення, замочування, заливання тощо), після використання утворюють плівки з тривалим бактерицидним ефектом (Verran et al, 2010;Lifencova & Gorpinchenko, 2016;Ding et al, 2017). Застосування цього засобу забезпечує виконання принципу: дезінфекція вважається ефективно проведеною, якщо знищенні патогенні мікроорганізми до рівня санітарно -гігієнічних вимог та відбувається заселення корисною мікрофлорою.…”