Development of novel dental restorative composites with dibasic calcium phosphate loaded chitosan fillers

Tanaka, Carina B.; Lopes, Diana Pereira; Kikuchi, Lucia Nobuco Takamori; Moreira, Maria Stella; Catalani, Luiz Henrique; Braga, Roberto Ruggiero; Kruzic, Jamie J.; Gonçalves, Flávio de Oliveira

doi:10.1016/j.dental.2020.02.004

Cited by 38 publications

(14 citation statements)

References 58 publications

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“…Small molecular monomers can be extracted in considerably larger amounts than large molecular monomers. 32 TEDGMA is a low-molecularweight monomer that exhibits greater mobility and is eluted faster than large molecules, such as Bis-GMA, 21 which may justify the prolonged inflammatory response observed in this study in resins with high Bis-GMA (Kerr®) concentration. Another contributing factor is the fact that Bis-GMA is poorly water soluble, making it difficult to dissolve over time.…”

Section: Discussionmentioning

confidence: 87%

“…Thus, corroborating the literature, there is a direct relationship between DC and the intensity of the inflammatory infiltrate. 19 DC reduction impairs the chemical and mechanical proprieties of BF resins, 20 and the high bioavailability of monomeric residues is strongly toxic to several cell types, 21 such as fibroblasts 22 and odontoblasts. 23 The direct contact of monomeric residues active apoptosis regulatory caspases causes toxicity and an inflammatory process, 24 as shown in Kerr® BF resin disks, negatively affecting pulp tissue, 25 following unbound composite diffusion through the dentine to the pulp.…”

Section: Discussionmentioning

confidence: 99%

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Influence of the degree of conversion and Bis-GMA residues of bulk fill resins on tissue toxicity in an subcutaneous model in rats

Girão

Martins

Lemos

et al. 2020

Journal of Applied Biomaterials & Functional Materials

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Aim: To analyse the influence of the degree of conversion (DC) and light curing residues of different bulk fills (BFs) composites on the inflammatory profile in the subcutaneous tissue of rats. Materials and methods: Resin disks of BF-resins and their active conventional resins (CR; 3M®, Ivoclar®, and Kerr®) were light-cured at 2 mm (BF-superficial) and 4 mm (BF-deep) thicknesses and analyzed by infrared spectroscopy (FTIR; n = 3/group; DC and light curing residues). Then, the disks were implanted in four quadrants in the subcutaneous tissue of Wistar rats (sham, CR, BF-superficial and RF-deep), and after 7, 14, and 28 days, the animals ( n = 6/day) were euthanized for histological analysis of the intensity of the inflammatory process (scores 0–3). Kruskal–Wallis/Dunn and ANOVA/Bonferroni tests were used ( p < 0.05, Graph Pad Prism 5.0). Results: The DC of CR 3M® did not differ significantly compared to BF-superficial and BF-deep resins ( p = 0.235). The Ivoclar® and Kerr® resins showed a higher DC with CR and BF-superficial compared to the BF-deep ( p = 0.005 and p = 0.011, rctively). Kerr® resins showed a higher Bis-GMA/UDMA ratio, especially in BF-deep resin ( p < 0.05). 3M® and Ivoclar resins did not show high inflammation scores, but for Kerr® BF resins (superficial and deep), the inflammatory process was significantly higher than that in the CR and sham quadrants ( p = 0.031). Conclusion: The tissue inflammatory response after resin inoculation depends on the DC and light curing residues of Bis-GMA.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Influence of the degree of conversion and Bis-GMA residues of bulk fill resins on tissue toxicity in an subcutaneous model in rats

Girão

Martins

Lemos

et al. 2020

Journal of Applied Biomaterials & Functional Materials

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“…In this strategy, polymers containing insoluble positively charge species such as quaternary ammonium compounds (QACs) have been widely explored [ 70 ]. Other polymerizable synthetic and natural compounds such as chitosan [ 71 ] and imidazole [ 72 ] have also been included. These materials have been proven to effectively reduce the growth of bacteria and microorganisms in a wide range of applications, such as dental materials, medical equipment, food packaging and coatings [ 21 , 69 , 73 , 74 ].…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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“…The coating material inhibited bacterial adhesion and reduced bacterial biofilm formation. Tanaka et al (2020) synthetized CS and CS/dibasic calcium phosphate anhydrous (DCPA) particles with the electrospray method and loaded them onto composite resins, a restorative dental composite. The CS and CS/DCPA particles could effectively improve the bacteriostatic activity without reducing other composite properties.…”

Section: Dental Materialsmentioning

confidence: 99%

Applications of chitosan-based biomaterials: a focus on dependent antimicrobial properties

Deng

Wang

Chen

et al. 2020

Mar Life Sci Technol

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Marine-derived chitosan has been widely examined for its use in developing biomedical materials. Not only is it non-toxic, biocompatible, and degradable, it has also shown unique antimicrobial properties. The antimicrobial properties of chitosan are restricted by neutral and physiological conditions because it is insoluble in water and its pKa values is 6.5. One solution to this problem is to graft chemically modified groups onto the backbone of chitosan. The aim of this paper is to review the mode of antimicrobial action of chitosan and chitosan derivatives. Using chitosan alone may not meet the demands of various applications. However, the introduction of additional polymers and antimicrobial agents is commonly used to enhance the antimicrobial potential of chitosan-based biomaterials. Chitosan-based composite biomaterials have been developed that allow diversified formulations to broaden applications, including nanoparticles, hydrogels, films, sponges, fibers, or even microspheres. These along with recent advances on chitosan-based composite biomaterials used for wound healing, food packaging, textile sector, 3D printing and dental materials, were reviewed in detail.

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Development of novel dental restorative composites with dibasic calcium phosphate loaded chitosan fillers

Cited by 38 publications

References 58 publications

Influence of the degree of conversion and Bis-GMA residues of bulk fill resins on tissue toxicity in an subcutaneous model in rats

Influence of the degree of conversion and Bis-GMA residues of bulk fill resins on tissue toxicity in an subcutaneous model in rats

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Applications of chitosan-based biomaterials: a focus on dependent antimicrobial properties

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