Development of Ointment Formulations Prepared with Achyrocline satureioides Spray-Dried Extracts

Abstract

Achyrocline satureioides spray-dried extracts, prepared with colloidal silicon dioxide, microcrystalline cellulose + colloidal silicon dioxide (1:1), and beta-cyclodextrin + colloidal silicon dioxide (1:1), were incorporated in a glyceryl monostearate base. The influence of the spray-drying adjuvants on the formulations' physical characteristics, such as spreading properties, oil indexes, viscosities, and the pH determination, were evaluated. The results indicated that the adjuvants influenced the ointments' physical parameters at different levels, although all of them maintained their plastic flow and presented antithixotropic behavior. The presence of colloidal silicon dioxide alone, in the dried extract, imparted the lowest oil index value and an intermediary spreading area to the ointment. The colloidal silicon dioxide content reduction and the substitution of part of it by beta-cyclodextrin or microcrystalline cellulose enhanced the ointments' oil index values, while the best spreading area was reached by the ointment prepared with the spray-dried extract containing colloidal silicon dioxide and microcrystalline cellulose.

Caracterização físico-química do extrato fluido e seco por nebulização de Symphytum officinale L.

“…A otimização dos parâmetros de secagem como temperaturas de entrada e saída, velocidade de fl uxo de alimentação, concentração e tipo de adjuvante tecnológico, assim como os teores de resíduo seco do extrato fl uido a nebulizar são fatores indispensáveis para obtenção de extratos secos com melhores características físico-químicas e aumento do rendimento da operação (Gaudy et al, 1991;Paula et al, 1998.…”

Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações

“…De Paula et al (1998) e Teixeira (1996 avaliaram a influência da composição qualitativa na secagem de soluções extrativas de Achyrocline satureioides (Lam.) DC.…”

“…DC foram desenvolvidas, avaliandose os adjuvantes utilizados no processo de secagem no que tange às características físicas da formulação, tais como, espalhamento, viscosidade, pH e índice de óleo. Dependendo da composição qualitativa e quantitativa dos produtos secos foram observados comportamentos diferenciados (De Paula et al, 1998).…”

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

“…The glass plate of 100 ± 5 g was placed gently on the gel and the spread diameter was recorded after 1 minute; subsequent glass plates were added and the spread diameter was recorded after 1 minute of each addition. Results were presented as the spreading area being a function of the applied mass (17). Spreadability of the developed formulation was compared with the commercial formulation Candid-V gel.…”