Development of Peptidergic Systems in the Rat Brain

Swaab, D.F.; Borg, Julia

doi:10.1002/9780470720684.ch13

Cited by 5 publications

(2 citation statements)

References 93 publications

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“…Understanding the development of this system can provide insight into how individual differences in social behavior arise, and elucidate sources of behavioral dysfunction. The ontogeny of VP and OT neuronal populations has been examined in rodents (DiBenedictis et al 2017; Grinevich et al 2014; Swaab and Ter Borg 1981; Boer et al 1980; Yamamoto et al 2004), demonstrating that these cell groups are present at parturition, although dendritic and axonal growth, and neuron number, continue to grow in the first weeks after birth (Hammock 2015; Grinevich et al 2014; Tamborski et al 2016). Although the anatomical distribution of nonapeptide neurons throughout development has been described, their functional roles during the early development are surprisingly understudied.…”

Section: Introductionmentioning

confidence: 99%

“…The ontogeny of rodent nonapeptide neuron and receptor anatomical distributions has been described in rats (Boer et al 1980; DiBenedictis et al 2017; Krisch 1980; Smith et al 2017; Swaab and Ter Borg 1981), mice (Godefroy et al 2017), jirds (Rabhi et al 1996, 1999), and voles (lateral septum nonapeptide receptors only, Wang and Young 1997; PVN VP and OT neurons only; Yamamoto et al 2004). However, to our knowledge, it is largely unknown whether nonapeptide neurons exhibit distinct functional properties or play different functional roles in behavior at different stages of development, particularly during rapid brain growth stages.…”

Section: Introductionmentioning

confidence: 99%

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Rapid nonapeptide synthesis during a critical period of development in the prairie vole: plasticity of the paraventricular nucleus of the hypothalamus

2018

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Vasopressin (VP) and oxytocin (OT) are involved in modulating basic physiology and numerous social behaviors. Although the anatomical distributions of nonapeptide neurons throughout development have been described, the functional roles of VP and OT neurons during development are surprisingly understudied, and it is unknown whether they exhibit functional changes throughout early development. We utilized an acute social isolation paradigm to determine if VP and OT neural responses in eight nonapeptide cell groups differ at three different stages of early development in prairie voles. We tested pups at ages that are representative of the three rapid growth stages of the developing brain: postnatal day (PND)2 (closed eyes; poor locomotion), PND9 (eye opening; locomotion; peak brain growth spurt), and PND21 (weaning). Neural responses were examined in pups that (1) were under normal family conditions with their parents and siblings, (2) were isolated from their parents and siblings and then reunited, and (3) were isolated from their parents and siblings. We found that VP and OT neural activity (as assessed via Fos co-localization) did not differ in response to social condition across development. However, remarkably rapid VP and OT synthesis in response to social isolation was observed only in the paraventricular nucleus of the hypothalamus (PVN) and only in PND9 pups. These results suggest that PVN nonapeptide neurons exhibit distinct cellular properties during a critical period of development, allowing nonapeptide neurons to rapidly upregulate peptide production in response to stressors on a much shorter timescale than has been observed in adult animals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rapid nonapeptide synthesis during a critical period of development in the prairie vole: plasticity of the paraventricular nucleus of the hypothalamus

2018

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Ontogeny of the novel tachykinins neurokinin A, neurokinin B and neuropeptide K in the rat central nervous system

Díez‐Guerra

Veira

Augood

et al. 1989

Regulatory Peptides

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Pro-opiomelanocortin mRNA and peptide co-expression in the developing rat pituitary

Khachaturian

Kwak

Schäfer

et al. 1991

Brain Research Bulletin

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Pro-opiomelanocortin (POMC) is synthesized in both the pituitary gland and the brain. Various peptide products of this precursor, namely beta-endorphin, ACTH and alpha-MSH are co-localized in the anterior lobe corticotrophs, all intermediate lobe cells and in hypothalamic neurons. Messenger RNA (mRNA) for POMC has further been shown to exist in these tissues. In this study, we have shown that POMC mRNA, and peptide accumulation as detected by in situ hybridization and immunocytochemistry, respectively, occur simultaneously within the rat pituitary gland during ontogeny and that their maturation occurs in parallel during prenatal and early postnatal development.

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Development of Peptidergic Systems in the Rat Brain

Cited by 5 publications

References 93 publications

Rapid nonapeptide synthesis during a critical period of development in the prairie vole: plasticity of the paraventricular nucleus of the hypothalamus

Rapid nonapeptide synthesis during a critical period of development in the prairie vole: plasticity of the paraventricular nucleus of the hypothalamus

Ontogeny of the novel tachykinins neurokinin A, neurokinin B and neuropeptide K in the rat central nervous system

Pro-opiomelanocortin mRNA and peptide co-expression in the developing rat pituitary

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