Development of pH-sensitive biomaterial-based nanocomposite for highly controlled drug release

Heragh, Bagher Kazemi; Javanshir, Shahrzad; Mahdavinia, Gholam Reza; Naimi‐Jamal, M. Reza

doi:10.1016/j.rinma.2022.100324

Cited by 9 publications

(5 citation statements)

References 89 publications

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“…5 c shows the FTIR spectra of pristine MTZ and MTZ-B1-C1 hydrogel. From the figure, it is observed that the spectrum of pristine MTZ shows an absorption band at 3221 cm −1 (O–H stretching vibrations), band at and 3099 cm −1 (imidazole, C C–H, stretching vibration) [ 53 , 54 ], and the C–H of the methyl (–CH 3 ) groups and alkyl (–CH 2 –) chains stretching vibrational bands are at 2937 and 2853 cm −1 [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…The bands at 1807 cm −1 and 1473 cm −1 are due to N–O stretching (asymmetric and symmetric asymmetric) of NO 2 bonds [ 56 ]. The bands at 1535 and 1367 cm −1 (nitroso, N–O stretching), 1263 cm −1 (–C C– stretching), 1186 cm −1 (–C N stretching), 1072 cm −1 (C–O stretching), 824 cm −1 (C–H stretching) [ 16 , 53 ]. The observed FTIR spectra in MTZ-B1-C1 at 1645 cm −1 (C O stretching), at 1110 cm −1 (C–H of benzene ring deformation vibration), and 1381 cm −1 (-CH 2 bond bending vibrations).…”

Section: Resultsmentioning

confidence: 99%

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Development of double crosslinked sodium alginate/chitosan based hydrogels for controlled release of metronidazole and its antibacterial activity

Feyissa,

Edossa,

Gupta

et al. 2023

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Development of double crosslinked sodium alginate/chitosan based hydrogels for controlled release of metronidazole and its antibacterial activity

Feyissa,

Edossa,

Gupta

et al. 2023

Heliyon

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“…The release amount of the combination was higher in the acidic pH than that of neutral environment. The controlled release might be due to the electrostatic repulsion force between the metronidazole and chitosan in acidic medium ( Heragh et al, 2022 ) ( Figure 1 ). Research investigating films composed of chitosan-Ag nanoparticles suggests a stronger antibacterial effect against Gram-negative bacteria compared to their Gram-positive counterparts.…”

Section: Metal/metal-oxide Nanocompositesmentioning

confidence: 99%

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Saravanan,

Subramani,

Rajaramon

et al. 2023

Front. Pharmacol.

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Nanocomposites, formed by combining a matrix (commonly polymer or ceramic) with nanofillers (nano-sized inclusions like nanoparticles or nanofibers), possess distinct attributes attributed to their composition. Their unique physicochemical properties and interaction capabilities with microbial cells position them as a promising avenue for infectious disease treatment. The escalating prevalence of multi-drug resistant bacteria intensifies the need for alternative solutions. Traditional approaches involve antimicrobial agents like antibiotics, antivirals, and antifungals, targeting specific microbial aspects. This review presents a comprehensive overview of diverse nanocomposite types and highlights the potential of tailored matrix and antibacterial agent selection within nanocomposites to enhance treatment efficacy and decrease antibiotic resistance risks. Challenges such as toxicity, safety, and scalability in clinical applications are also acknowledged. Ultimately, the convergence of nanotechnology and infectious disease research offers the prospect of enhanced therapeutic strategies, envisioning a future wherein advanced materials revolutionize the landscape of medical treatment.

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“…Figure 4(b) shows the FTIR spectra of pristine MTZ and MTZ-H2-G3 hydrogel. From Figure 4(b), it is observed that the spectrum of pristine MTZ shows an absorption band between 3221 attributed to stretching vibrations of the O-H groups, peak at 3099 cm −1 is due to the stretching vibration of imidazole (C=C-H) [52,53], the peaks at 2937 and 2853 cm −1 are attributed to the stretching of the C-H of the methyl (-CH3) and alkyl (-CH2-) groups [54]. The peaks at 1807 cm −1 and 1473 cm −1 are due to asymmetric N-O stretching and symmetric stretching of NO 2 bonds.…”

Section: Ftir Analysis Figures 4(a)mentioning

confidence: 99%

“…The peaks at 1807 cm −1 and 1473 cm −1 are due to asymmetric N-O stretching and symmetric stretching of NO 2 bonds. The peaks at 1535 and 1367 cm −1 (nitroso N-O stretching), 1263 cm −1 (-C=C-), 1186 cm −1 (-C=N stretching), 1072 cm −1 (C-O stretching), 824 cm −1 (C-H stretching) [15,52].…”

Section: Ftir Analysis Figures 4(a)mentioning

confidence: 99%

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties

Feyissa

Edossa

Bedasa

et al. 2023

International Journal of Polymer Science

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This research focused on preparing hydrogels with controlled drug release properties to control gastrointestinal tract bacterial infection. Chitosan (CS) and polyvinylpyrrolidone (PVP) were used as the base polymers, with the CS component crosslinked by glutaraldehyde for hydrogel preparation using the solution casting technique. The effect of varying glutaraldehyde content in the hydrogels was characterized by the extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4; the development of porosity; and gel fraction. Functional groups and covalent and hydrogen bonds formed, thermal stability, phase structure, and morphology were characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. The results show that the components in the hydrogels have good compatibility and formed honeycomb-like structures. In vitro studies confirmed that the hydrogels have good biodegradability at pH 7.4. Based on these properties, a CS/PVP hydrogel of the ratio of 60 : 40 crosslinked with 600 μL glutaraldehyde was selected for the in-situ loading of 200 mg of the drug metronidazole (MTZ). The hydrogel was characterized for cumulative drug release in the simulated physiological fluids and drug release kinetics using different models and for its antibacterial activity. The best-fit Korsmeyer–Peppas model suggests that MTZ release followed diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This hydrogel displays enhanced antimicrobial activity against Staphylococcus aureus, and Escherichia coli showed substantial inhibition zones indicating the produced CS/PVP hydrogels are promising candidates for controlled drug release applications.

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Development of pH-sensitive biomaterial-based nanocomposite for highly controlled drug release

Cited by 9 publications

References 89 publications

Development of double crosslinked sodium alginate/chitosan based hydrogels for controlled release of metronidazole and its antibacterial activity

Development of double crosslinked sodium alginate/chitosan based hydrogels for controlled release of metronidazole and its antibacterial activity

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties

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