Development of pharmacognostic parameters for the leaf of Bridelia scandens (Roxb.) Willd

Preetham, J.; Kiran, S. Ravi; Sharath, R.; Sundari, P. Sivakami; Ganapathy, PS; Hm, Kumaraswamy

doi:10.31254/phyto.2021.10403

Cited by 3 publications

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“…Leaf material was weighed and transferred to a sterile mortar and pestle to make a crude crushing of the material, which was then transferred to a sterile homogenizer and finely crushed. About 100 grams of coarsely powdered plant material was exhaustively extracted for 2 h with 200 ml of different solvents individually at their boiling point temperature in Soxhlet apparatus 28 . The extracts obtained were filtered and evaporated under reduced pressure using rotary evaporator (Jyoti Scintific, India 29 .…”

Section: Animals Housing and Feeding Conditionsmentioning

confidence: 99%

Untitled

2023

IJPSR

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Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are the basis of traditional medicine. Any damage or break in the surface of the skin is a wound. In Soxhlet extraction, solvent extraction involves extraction with solvents of increasing polarity from a nonpolar to a more polar solvent to ensure that a wide polarity range of compounds can be extracted. 1 % of the extract was incorporated in the preparation of gel formulation using Carbomer 940 polymer as gelling agent. Three formulae 1, 2 and 3 of gel containing varying concentrations of Carbomer 940(0.5, 1 and 1.5%) were prepared. Carbomer 940 was soaked in distilled water overnight. Selected extracts were dissolved in ethanol. Standard methods and results examined different Physicochemical evaluation parameters of formulated ointments were found within the acceptable limits. Cissampelos Pareira Vein-islet number/mm 2 was 3.6 and it ranges from 3.5 to 3.9. The Palisade ratio was 3, and it ranges from 2.75 to 3.75. The Stomata length (µm) was found to be 20.5 and it ranges from 18.1 to 22.7. Hence we can conclude from our findings that the developed formulations containing bioactive Methanol extracts of Cissampelos Pareira and Bergenia ciliate formulation acted on each component of the wound healing process.

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Section: Animals Housing and Feeding Conditionsmentioning

confidence: 99%

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2023

IJPSR

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“…B. stipularis is used in pleurisy and exudation. Warm leaf poultice and leaf powder are used to white spots in skin for the treatment of allergies in children [6] . B. stipularis is used in amoebic dysentery, constipation, chest pain, leucoderma, diarrhoea, and strangury decoction [7] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of toxicological, anti-allergic and neuropharmacological activities of <em>Bridelia stipularis</em>: <em>In-vivo</em> and in-silico studies

Acharyya¹,

Mitra²,

Risha³

et al. 2022

J. Med. Plants Stud.

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Bridelia stipularis locally known as 'Harinhara' native in hill tract area. The plant is traditionally used in cough, asthma and catarrh by the Chakma ethnic people of Bangladesh. In this study, we investigated the toxicological, anti-allergic, neuropharmacological potential of leaves extract and profiling of its bioactive polyphenols by HPLC for in-silico molecular docking. Phytochemical test confirmed the existence of phytochemicals including tannin, flavonoid, saponin, alkaloid, glycoside etc. In toxicity study, the extract was safe up to 3 g/kg oral dose in mice. The studied showed no organ specific toxicity at 500 mg/kg oral dose. Anti-allergic activity performed by using TDI-induced allergic mice model. The extract significantly reduced the TDI-induced allergy like symptoms such as scratching, sneezing, swelling (P < 0.05). Additionally, the extract also ameliorated the leukocytes count in blood and bronchoalveolar lavage (BAL) fluid. The neuropharmacological activity test was conducted by following the open field method in mice model, at both doses of extract at 300 and 500 mg/kg showed mild CNS depressant effect. HPLC profiling identified the presence of seven phenolic compounds, among these rutin hydrate demonstrated the best docking score of -7.4 kcal/mol same as anti-allergic drug against (H1R). On the other hand exhibited rosmarinic acid and myricetin -7.9 and -7.8 kcal/mol against GABAA whereas standard CNS drug showed -7.7 kcal/mol. In conclusion, B. stipularis is safe and rich in different polyphenolic compounds which were found effective against diseases.

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Antioxidant Potential of Medicinal Plants in the Treatment of Scabies Infestation

Wróblewski,

Wróblewska,

Nuszkiewicz

et al. 2024

Molecules

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Oxidative stress, characterized by an overproduction of reactive oxygen species that overwhelm the body’s physiological defense mechanisms, is a key factor in the progression of parasitic diseases in both humans and animals. Scabies, a highly contagious dermatological condition caused by the mite Sarcoptes scabiei var. hominis, affects millions globally, particularly in developing regions. The infestation leads to severe itching and skin rashes, triggered by allergic reactions to the mites, their eggs, and feces. Conventional scabies treatments typically involve the use of scabicidal agents, which, although effective, are often associated with adverse side effects and the increasing threat of resistance. In light of these limitations, there is growing interest in the use of medicinal plants as alternative therapeutic options. Medicinal plants, rich in bioactive compounds with antioxidant properties, offer a promising, safer, and potentially more effective approach to treatment. This review explores the role of oxidative stress in scabies pathogenesis and highlights how medicinal plants can mitigate this by reducing inflammation and oxidative damage, thereby alleviating symptoms and improving patient outcomes. Through their natural antioxidant potential, these plants may serve as viable alternatives or complementary therapies in the management of scabies, especially in cases where resistance to conventional treatments is emerging.

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Development of pharmacognostic parameters for the leaf of Bridelia scandens (Roxb.) Willd

Cited by 3 publications

References 0 publications

Untitled

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Evaluation of toxicological, anti-allergic and neuropharmacological activities of <em>Bridelia stipularis</em>: <em>In-vivo</em> and in-silico studies

Antioxidant Potential of Medicinal Plants in the Treatment of Scabies Infestation

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