Development of ‘pharmacological denervation phenomenon’ in patients treated with atropine

Mózsik, Gy.; Jávor, T; Dobi, S; Petrássy, Klára; Szabó, Ágnes

doi:10.1016/0014-2999(67)90100-8

Cited by 19 publications

(16 citation statements)

References 22 publications

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“…The development of pharmaco logical denervation and of tolerance to parasympatholytics was proved in patients observed 2-4 weeks after treatment with atro pine [4,12,14]. These patients with the above-mentioned phenom ena are designated patients denervated pharmacologically.…”

Section: Resultsmentioning

confidence: 99%

“…The light flicker was used as an external un conditioned reflex inhibition on the parotid secretion [1], This form of inhibition produced by light flicker is interesting because it was produced not by drugs but by the central nervous system [4,12,14].…”

Section: Discussionmentioning

confidence: 99%

“…Thereafter parotid secretory responses were considered a suitable and objective meas ure of clinical pharmacological effects, of the pharmacodynamic actions of various parasympatholytics [4,5,6,10,12,14] and of excitatory and inhibitory processes within the nervous system [3].…”

Section: Discussionmentioning

confidence: 99%

“…In the present article effects of unconditioned nervous stimuli and of inhibition of such stimuli on the parotid secretory re sponses have been investigated in patients denervated pharmaco logically [12,14]. Central and peripheral excitatory and inhibitory nervous processes have been analyzed in these patients.…”

mentioning

confidence: 99%

“…This tolerance was re versed 3 to 6 days after cessation of atropine administration. De velopment of pharmacological denervation has previously been described during the period of tolerance to parasympatholytics [12,13,14].…”

mentioning

confidence: 99%

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Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Mózsik¹,

Lipák²

1970

Pharmacology

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Mózsik¹,

Lipák²

1970

Pharmacology

Self Cite

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Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs

Fleming¹,

McPhillips²,

Westfall

1973

Ergebnisse Der Physiologie Reviews of Physiology, Volume 68

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Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

Mózsik

2014

Capsaicin as a Therapeutic Molecule

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Background: Capsaicin is a specific compound acting on capsaicin-sensitive afferent nerves. Aim: Capsaicin was used to study the different events of human gastrointestinal physiology, pathology, and clinical pharmacology, and possible therapeutic approaches to enhance gastrointestinal mucosal defense in healthy human subjects and in patients with various different gastrointestinal disorders as well as its use with nonsteroidal anti-inflammatory drugs (NSAIDs) in healthy subjects and in patients. Materials and Methods: The observations were carried out in 198 healthy human subjects and in 178 patients with different gastrointestinal (GI) diseases (gastritis, erosions, ulcer, polyps, cancer, inflammatory bowel diseases, colorectal polyps, cancers), and in 69 patients with chronic (Helicobacter pylori positive and negative) gastritis (before and after eradication treatment). The gastric secretory responses and their chemical composition, gastric emptying, sugar loading test, gastric transmucosal potential difference (GTPD) with application of capsaicin alone, after ethanol alone and with capsaicin, indomethacin-induced gastric mucosal microbleeding without and with capsaicin were studied. The immunohistochemical examinations of the capsaicin receptor (TRVP1), calcitonin gene-related peptide (CGRP), and substance P (SP) were carried out in gastrointestinal tract, and especially in patients with chronic gastritis (with and without Helicobacter infection, before and after classical eradication treatment). Classical molecular pharmacological methods were applied to study the drugs inhibiting the gastric basal acid output. Results: Capsaicin decreased the gastric basal output, enhanced the "non-parietal" (buffering) component of gastric secretory responses, and gastric emptying, and the release of glucagon. Capsaicin

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Development of ‘pharmacological denervation phenomenon’ in patients treated with atropine

Cited by 19 publications

References 22 publications

Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Central and Peripheral Excitatory and Inhibitory Nervous Processes in Patients Denervated Pharmacologically

Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs

Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Nonsteroidal Anti-Inflammatory Drugs in Healthy Human Subjects and in Patients

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