Development of photo and pH dual crosslinked coumarin-containing chitosan nanoparticles for controlled drug release

Rahimi, Shahnaz; Khoee, Sepideh; Ghandi, Mehdi

doi:10.1016/j.carbpol.2018.08.074

Cited by 40 publications

(16 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well documented in literature that the crosslinking degree strongly influences the morphology of the hydrogels. [1][2][3][4][5][6][7][8][9][10][11][12][13][14]18 To see how this parameter influenced the morphology in the particular case of cinnamyl-imine-chitosan hydrogels, SEM images of the corresponding xerogels were acquired at high magnification. Representative images were given for the series L1-L4 ( Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…1 Many studies dedicated to the chitosan, revealed that it is biocompatible, nontoxic (its degradation products are known natural metabolites), nonantigenic, haemostatic, antimicrobial, fungistatic, spermicidal, central nervous system depressant, immunoadjuvant and present antitumor activity, the ability to improve wound healing or clot blood, the ability to form protective films and coatings, selective binding of acidic liquids, thereby lowering serum cholesterol levels and hypertension prevention, property to accelerates bone formation or environmental protection. [1][2][3][4][5] All these features transformed the chitosan into a desired material for bio-applications. One direction which attracted the researchers' attention was the exploiting of chitosan for preparing hydrogels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control

Craciun

2018

Acta Chemica Iasi

View full text Add to dashboard Cite

The study deals with the exploration of the possibilities to control the morphology of cinnamyl-imine-chitosan hydrogels in view of their bio-application. Three series of hydrogels were synthetized from chitosan of three different molecular weights and cinnamaldehyde, varying the molar ratio between the amine groups on chitosan and aldehyde functional groups. The hydrogel morphology has been monitored by scanning electron microscopy. The variation of the hydrogel morphology as a function of chitosan molecular weight, crosslinking degree, and incubation conditions has been monitored. It was concluded that there are multiple possibilities of tuning the morphology of these hydrogels in function of the targeted application.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control

Craciun

2018

Acta Chemica Iasi

View full text Add to dashboard Cite

show abstract

“…Khoee and co‐workers developed UV‐ and pH‐dual responsive iminocoumarin‐chitosan nanoparticles (CS‐COU‐NPs) as drug carrier for quercetin, exposing higher stability after photo‐crosslinking of 8‐formyl‐7‐hydroxy‐4‐methyl coumarin (8‐FHMC) ( Figure a). Under physiological condition (pH 7.4), ≈20% quercetin was released from the photo‐crosslinked nanoparticles, while an accelerated release of 50% quercetin was achieved at pH 5.8 attributing to the acid‐induced cleavage of Schiff‐base linkage between chitosan and 8‐FHMC . Although photo‐crosslinking could stabilize nanoparticles and reduce the unexpected release of drug at pH 7.4, the photocrosslinked nanoparticles showed also slower drug release rate at lower pH condition and lower cytotoxicity for cancer cell proliferation in comparison to the non‐crosslinked nanoparticles (Figure b,c).…”

Section: Uv/vis Light Controlled Drug Delivery Systemsmentioning

confidence: 99%

“…a) Synthesis route of the photo‐crosslinked CS‐COU‐NPs; b) in vitro release of quercetin from photo‐crosslinked CS–COU–NPs in pH 7.4 (a) and 5.8 (c), and from non‐photo‐crosslinked CS–COU–NPs in pH 7.4 (b) and 5.8 (d); c) cytotoxicity assays of drug‐loaded CS–COU–NPs against HeLa tumor cells after incubation for 48 h: control (a), free 8‐FHMC (b), free quercetin (c), photo‐crosslinked CS–COU–NPs (d) and non‐photo‐crosslinked CS–COU–NPs (e). Reproduced with permission . Copyright 2018, Elsevier B.V.…”

Section: Uv/vis Light Controlled Drug Delivery Systemsmentioning

confidence: 99%

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Zhao

Wang

et al. 2019

Small

231

137

View full text Add to dashboard Cite

Engineering of smart photoactivated nanomaterials for targeted drug delivery systems (DDS) has recently attracted considerable research interest as light enables precise and accurate controlled release of drug molecules in specific diseased cells and/or tissues in a highly spatial and temporal manner. In general, the development of appropriate light‐triggered DDS relies on processes of photolysis, photoisomerization, photo‐cross‐linking/un‐cross‐linking, and photoreduction, which are normally sensitive to ultraviolet (UV) or visible (Vis) light irradiation. Considering the issues of poor tissue penetration and high phototoxicity of these high‐energy photons of UV/Vis light, recently nanocarriers have been developed based on light‐response to low‐energy photon irradiation, in particular for the light wavelengths located in the near infrared (NIR) range. NIR light‐triggered drug release systems are normally achieved by using two‐photon absorption and photon upconversion processes. Herein, recent advances of light‐responsive nanoplatforms for controlled drug release are reviewed, covering the mechanism of light responsive small molecules and polymers, UV and Vis light responsive nanocarriers, and NIR light responsive nanocarriers. NIR‐light triggered drug delivery by two‐photon excitation and upconversion luminescence strategies is also included. In addition, the challenges and future perspectives for the development of light triggered DDS are highlighted.

show abstract

“…In recent years, hydrogels have an increasing demand for drug delivery systems. The purpose of the drug delivery systems is to maintain drug concentration in the blood or in target tissues at prolonging drug-release times (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Şenol

Akyol

2019

Journal of the Turkish Chemical Society Section A: Chemistry

View full text Add to dashboard Cite

The aim of the present study is to develop hydroxyapatite-modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer's disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-hydroxy-4'-(2hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photoinitiators in the synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristic properties of hydrogels. Photopolymerization technique was selected for the synthesis of hydrogels. Swelling and drug release studies have been performed under different pH conditions.

show abstract

Development of photo and pH dual crosslinked coumarin-containing chitosan nanoparticles for controlled drug release

Cited by 40 publications

References 43 publications

Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control

Cinnamyl-Imine-Chitosan Hydrogels. Morphology Control

Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives

Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Contact Info

Product

Resources

About