Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Abstract

The aim of the present study is to develop hydroxyapatite-modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer's disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-hydroxy-4'-(2hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photoinitiators in the synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristic properties of hydrogels. Photopolymerization technique was selected for the synthesis of hydrogels. Swelling and drug release studies have been performed under different pH conditions.

Preparation of Photopolymerizable HEMA/PEG-DA Based Hydrogels Filled with Low Concentrations of Nanoparticle Titanium Dioxide for Release Of Donepezil HCl

“…We have previously reported that PEG-DA, HEMA hydrogels have a favorable behaviour for controlled release of Donepezil HCL [1,6,7]. Although promising results have been achieved in our studies, further studies are needed.…”

“…The main target of researchers to increase drug dosage and inhibit side effects on patients. Controlled release provides no continuous daily usage [1].…”

Atmospheric-Pressure Plasma Jet-Induced Graft Polymerization of Composite Hydrogel on 3D-Printed Polymer Surfaces for Biomedical Application

“…Moreover, UV light graft polymerization technology can achieve the purpose of selectively grafting and crosslinking monomers with different functional groups. Currently, UV light graft polymerization is one of the primary methods for synthesizing hydrogels in the biomedical field [35][36][37]. Due to its wide application, the UV light polymerization method has received considerable attention.…”

“…Hydrogel is an easy-to-prepare hydrophilic polymer with a three-dimensional network structure. When water penetrates the network structure to cause swelling, the formation of the network structure is mainly due to the cross-linking reaction between molecular chains [32,[36][37][38]. Moreover, the properties of the hydrogel can be changed by modification, so it has excellent research potential in tissue engineering [39,40].…”

In-vitro evaluation of co-excipients for release of donepezil hydrochloride from Carbopol 974P based tablets

“…[15][16][17][18] Stability and pH responsiveness are selective properties for controlled drug delivery systems. [19][20][21] Sustained release tablets (SRT) are suitable for overcoming shortcomings because of bioavailability, shorter biological halflife and high solubility in water so SRT is known as the most effective dosage form for such Alzheimer's disease and controlled drug delivery systems are attractive for supporting human health care. 22,23 Alzheimer's disease (AD) is a progressive brain disease and is highly prevalent in society older aged.…”