Development of pollen-induced allergic rhinitis with early and late phase nasal blockage in guinea pigs

Abstract

These results indicate that the experimental allergic rhinitis established in the present study can be a valuable model for analyzing the pathogenesis of the disease and developing new therapeutic drugs.

A new murine model of allergic rhinitis by repeated intranasal Cry j 1 challenge

“…Multiple animal models of allergic rhinitis have been used to evaluate pharmacotherapy and immunotherapy (6,9,10,13,14). Nasal blockage and sneezing occur in guinea pigs given repeated inhalation challenges with Cj pollen (10).…”

“…Nasal blockage and sneezing occur in guinea pigs given repeated inhalation challenges with Cj pollen (10). Antigen-induced nasal symptoms, late-phase nasal eosinophilia, and serum levels of antigen-specific IgE antibody were evaluated in an ovalbumin-sensitized BALB/c mouse model of allergic rhinitis (9,13).…”

Aggravation of Allergic Rhinitis by Air Pollution: Demonstration by an Animal Model of Pollenosis

“…Regarding nasal blockage, both early and late phase nasal blockage were induced with their respective peaks at 1-2 h and 4-6 h after pollen challenges. The magnitude of biphasic nasal blockage was enhanced until the 7th challenge, followed by induction of almost reproducible nasal blockage after respective pollen challenges until around 30 challenges (Nabe, 1998). Images of the timecourse of sneezing, and early and late phase nasal blockage after a certain challenge period are illustrated in the lower right panel of Fig.…”

“…1, lower left panel) (Nabe, 1997a(Nabe, , 2005. In addition, after respective pollen challenges, sneezing was induced within 1 h after a challenge (Nabe, 1998). Regarding nasal blockage, both early and late phase nasal blockage were induced with their respective peaks at 1-2 h and 4-6 h after pollen challenges.…”

“…We have established an experimental allergic rhinitis model in sensitized guinea pigs, using Japanese cedar pollen as the antigen (Nabe, 1997a(Nabe, , 1998). This experimental model has been used to assess whether short and long-term daily treatment with pyrenes, BaP and 1-NP aggravate antigen-induced sneezing and nasal blockage (Mizutani, 2007).…”