Development of Poly(vinyl alcohol) (PVA)/Reduced Graphene Oxide (rGO) Electrospun Mats

Gozutok, Melike; Sadhu, Veera; Şaşmazel, Hilal Türkoğlu

doi:10.1166/jnn.2019.16290

Cited by 19 publications

(8 citation statements)

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“…The Gly has an anti-inflammatory response [15] and enhances bone mass density [16], and particularly its β polymorph has superior mechanical [17] and piezoelectric properties [18][19][20]. On the other hand, PCL and PVA, which are FDA-approved bioresorbable synthetic polymers, were utilized in membrane fabrication due to their biodegradability with non-toxic by-products (mainly CO 2 and H 2 O), biocompatibility, good tensile strength, and processability [21,22]. However, the rapid degradation rate with high shrinkage and absorption percentage and undesirable mechanical properties of the monolithic electrospun membrane act as limitations in using these materials in membrane fabrication.…”

Section: Introductionmentioning

confidence: 99%

Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

2021

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Glycine (Gly), which is the simplest amino acid, induces the inflammation response and enhances bone mass density, and particularly its β polymorph has superior mechanical and piezoelectric properties. Therefore, electrospinning of Gly with any polymer, including polyvinyl alcohol (PVA), has a great potential in biomedical applications, such as guided bone regeneration (GBR) application. However, their application is limited due to a fast degradation rate and undesirable mechanical and physical properties. Therefore, encapsulation of Gly and PVA fiber within a poly(ε-caprolactone) (PCL) shell provides a slower degradation rate and improves the mechanical, chemical, and physical properties. A membrane intended for GBR application is a barrier membrane used to guide alveolar bone regeneration by preventing fast-proliferating cells from growing into the bone defect site. In the present work, a core/shell nanofibrous membrane, composed of PCL as shell and PVA:Gly as core, was developed utilizing the coaxial electrospinning technique and characterized morphologically, mechanically, physically, chemically, and thermally. Moreover, the characterization results of the core/shell membrane were compared to monolithic electrospun PCL, PVA, and PVA:Gly fibrous membranes. The results showed that the core-shell membrane appears to be a good candidate for GBR application with a nano-scale fiber of 412 ± 82 nm and microscale pore size of 6.803 ± 0.035 μm. Moreover, the wettability of 47.4 ± 2.2° contact angle (C.A) and mechanical properties of 135 ± 3.05 MPa average modulus of elasticity, 4.57 ± 0.04 MPa average ultimate tensile stress (UTS), and 39.43% ± 0.58% average elongation at break are desirable and suitable for GBR application. Furthermore, the X-ray diffraction (XRD) and transmission electron microscopy (TEM) results exhibited the formation of β-Gly.

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Section: Introductionmentioning

confidence: 99%

Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

2021

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“…More specifically, the addition of 15 wt% TRG could increase the thermally conductive coefficient (λ) value of pure PS from 0.226 to 0.689 W/mK, glass transition coefficient ( ) value from 0.2157 to 0.6545 mm 2 /s, glass transition temperature ( ) value from 90.3 to 95.0 °C and heat-resistance index ( ) value from 184.2 to 194.3 °C. Gozutok et al [ 184 ] observed that, adding rGO to PVA improved the thermal stability as shown in Fig. 4 c. Abdali and Ajji [ 163 ] reported that, the thermal stability of PANI improved in the presence of graphene as shown in Fig.…”

Section: Properties Of Electrospun Gnms Nanocompositesmentioning

confidence: 99%

“…Finally, the RGO decorated composite mat was obtained after washing with ethanol and drying at 60 °C for 12 h. Samani et al [148] observed an increase in the conductivity and mechanical properties when adding graphene in the polymer matrix for electrospinning. Gozutok et al [184] dispersed rGO in the poly (vinyl alcohol) (PVA) solutions without using any co-solvent and then electrospinning was used to fabricate nanofiber mats. By adding rGO, the properties of the PVA/rGO NF composite such as the porosity, inter fiber, pore size, and average fiber diameter were relatively improved.…”

Section: Electrospinning Design Of Gnms Nf Composites Using Post-procmentioning

confidence: 99%

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Graphene impregnated electrospun nanofiber sensing materials: a comprehensive overview on bridging laboratory set-up to industry

2020

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Owing to the unique structural characteristics as well as outstanding physio-chemical and electrical properties, graphene enables significant enhancement with the performance of electrospun nanofibers, leading to the generation of promising applications in electrospun-mediated sensor technologies. Electrospinning is a simple, cost-effective, and versatile technique relying on electrostatic repulsion between the surface charges to continuously synthesize various scalable assemblies from a wide array of raw materials with diameters down to few nanometers. Recently, electrospun nanocomposites have emerged as promising substrates with a great potential for constructing nanoscale biosensors due to their exceptional functional characteristics such as complex pore structures, high surface area, high catalytic and electron transfer, controllable surface conformation and modification, superior electric conductivity and unique mat structure. This review comprehends graphene-based nanomaterials (GNMs) (graphene, graphene oxide (GO), reduced GO and graphene quantum dots) impregnated electrospun polymer composites for the electro-device developments, which bridges the laboratory setup to the industry. Different techniques in the base polymers (preprocessing methods) and surface modification methods (post-processing methods) to impregnate GNMs within electrospun polymer nanofibers are critically discussed. The performance and the usage as the electrochemical biosensors for the detection of wide range analytes are further elaborated. This overview catches a great interest and inspires various new opportunities across a wide range of disciplines and designs of miniaturized point-of-care devices.

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“…Polyvinyl alcohol (PVA) is a synthetic polymer increasingly utilised in biotechnology, pharmaceutical, food chemistry and medicine, as a film, hydrogel or nanofibers. The significant drivers to using PVA in the medical and pharmaceutical fields are the biocompatibility, processability and hydrophilicity features [17][18][19] and the Food and Drug Administration (FDA) approval 17,20 . PVA is categorized into fully hydrolyzed and partially hydrolyzed 21 .…”

Section: Epidermal and Fibroblast Growth Factors Incorporated Polyvinmentioning

confidence: 99%

Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold

Asiri

Saidin

Sani

et al. 2021

Sci Rep

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In this study, single, mix, multilayer Polyvinyl alcohol (PVA) electrospun nanofibers with epidermal growth factor (EGF) and fibroblast growth factor (FGF) were fabricated and characterized as a biological wound dressing scaffolds. The biological activities of the synthesized scaffolds have been verified by in vitro and in vivo studies. The chemical composition finding showed that the identified functional units within the produced nanofibers (O–H and N–H bonds) are attributed to both growth factors (GFs) in the PVA nanofiber membranes. Electrospun nanofibers' morphological features showed long protrusion and smooth morphology without beads and sprayed with an average range of 198–286 nm fiber diameter. The fiber diameters decrement and the improvement in wettability and surface roughness were recorded after GFs incorporated within the PVA Nanofibers, which indicated potential good adoption as biological dressing scaffolds due to the identified mechanical properties (Young’s modulus) in between 18 and 20 MPa. The MTT assay indicated that the growth factor release from the PVA nanofibers has stimulated cell proliferation and promoted cell viability. In the cell attachment study, the GFs incorporated PVA nanofibers stimulated cell proliferation and adhered better than the PVA control sample and presented no cytotoxic effect. The in vivo studies showed that compared to the control and single PVA-GFs nanofiber, the mix and multilayer scaffolds gave a much more wound reduction at day 7 with better wound repair at day 14–21, which indicated to enhancing tissue regeneration, thus, could be a projected as a suitable burn wound dressing scaffold.

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Development of Poly(vinyl alcohol) (PVA)/Reduced Graphene Oxide (rGO) Electrospun Mats

Cited by 19 publications

References 0 publications

Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

Graphene impregnated electrospun nanofiber sensing materials: a comprehensive overview on bridging laboratory set-up to industry

Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold

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