Development of porous lamellar chitosan‐alginate membranes: Effect of different surfactants on biomaterial properties

Abstract

In this work, porous lamellar chitosan-alginate membranes were developed without the use of freeze-drying methods or other vacuum-based approaches. The effects of two different surfactants, Tween 80 and Pluronic F68, on the properties of the membranes were evaluated, aiming at the production of stable consistent foams with improved polysaccharide dispersion. The membranes prepared with Tween 80 had a tensile strength around 1.5 MPa, elongation at break of 2.1% and liquid uptake from 590 to 1370% in distinct solutions, increasing their thickness in up to 3.9 times when immersed in water. The membranes obtained with Pluronic F68 had a tensile strength of 1.0 MPa, elongation at break of 2.0% and liquid uptake from 774 to 1380%, showing an increase in thickness around 3.2 times after exposure to water. The antimicrobial properties of both membranes were also evaluated, showing that despite being porous, the membranes can provide some protection against bacterial permeation. Therefore, membranes produced with Tween 80 and Pluronic F68 were considered to have high potential for use in the production of wound dressings and scaffolds for tissue engineering.

Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings

“…Although the porosity was not calculated, both membranes were porous, and the membrane treated with Pluronic F68 displayed a higher porosity than the one treated with Tween 80. The membranes treated with either Pluronic F68 or Tween 80 displayed no zone of inhibition against Pseudomonas aeruginosa and Staphylococcus aureus [106]. This implies that the membranes did not possess any antibacterial properties, therefore an antibacterial drug may be introduced to the membranes.…”

“…The membrane treated with Tween 80 had the highest tensile strength of about 1.5 MPa, elongation at break of 2.1%, fluid uptake from 590 to 1370%, and the membrane increased in thickness up to 3.9 times when immersed in water [106]. The membranes treated with Pluronic F68 had a tensile strength of 1 MPa, elongation at break of 2%, fluid uptake from 774 to 1380%, and displayed increased thickness of about 3.2 times after exposure to water [106]. The tensile strength of both membranes was too high for wound dressing applications; however, the fluid uptake was still in the acceptable range.…”

ZnO microparticle‐loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere‐based nanocomposite thin film wound dressings for accelerated wound healing

“…fabricated ciprofloxacin‐loaded alginate/chitosan sponges and established that the obtained product could be used as a very promising alternative wound dressing to use in wound/burn dressing applications and wound healing studies. Zorzi Bueno and Maria Moraes are reported that chitosan/alginate composite films can be used as appropriate wound dressings or scaffolds in the tissue engineering field. The adhesive nature of chitosan, arising from the cationic structure, promotes cell adhesion due to the electrostatic interaction with anionic glycosaminoglycan and proteoglycans, which have substantial contributions in growth differentiation and migration process of fibroblasts.…”

“…Also, it provides an accelerated skin regeneration by increasing natural hyaluronic acid formation at the wound area as a result of N ‐acetyl‐β‐ d ‐glucosamine releasing during the depolymerization. These characteristics make it a perfect biopolymer for the promising biomedical applications …”

Modified poly(vinyl alcohol)/chitosan blended membranes for isopropanol dehydration via pervaporation: Synthesis optimization and modeling by response surface methodology

“…In the present work, the PVA/CS blended membranes were prepared with different CS loadings at fixed total polymer content. CS is one of the most abundant biopolymer in nature and is N‐deacetylated derivatives of chitin which naturally exists in some creatures such as insects and marine crustaceans . High number of reactive amino and hydroxyl groups along with high mechanical strength and good film‐forming ability make CS a promising candidate as the second hydrophilic polymer to form a blend with PVA.…”