Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)

Abstract

The drug yielding potential of turmeric (Curcuma longa L.) is largely due to the presence of phyto-constituent ‘curcumin.’ Curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. Lack of requisite high curcumin containing genotypes and variation in the curcumin content of turmeric at different agro climatic regions are the major stumbling blocks in commercial production of turmeric. Curcumin content of turmeric is greatly influenced by environmental factors. Hence, a prediction model based on artificial neural network (ANN) was developed to map genome environment interaction basing on curcumin content, soli and climatic factors from different agroclimatic regions for prediction of maximum curcumin content at various sites to facilitate the selection of suitable region for commercial cultivation of turmeric. The ANN model was developed and tested using a data set of 119 generated by collecting samples from 8 different agroclimatic regions of Odisha. The curcumin content from these samples was measured that varied from 7.2% to 0.4%. The ANN model was trained with 11 parameters of soil and climatic factors as input and curcumin content as output. The results showed that feed-forward ANN model with 8 nodes (MLFN-8) was the most suitable one with R2 value of 0.91. Sensitivity analysis revealed that minimum relative humidity, altitude, soil nitrogen content and soil pH had greater effect on curcumin content. This ANN model has shown proven efficiency for predicting and optimizing the curcumin content at a specific site.

Curcuma longa L. Rhizome Essential Oil from Extraction to Its Agri-Food Applications. A Review

“…Additionally, they have demonstrated promising antioxidant and anti-inflammatory activities, being considered a valuable complementary therapy to pharmaceuticals in Crohn’s, diabetes and cancer between other disorders [ 15 , 21 , 22 ]. Unfortunately, their poor solubility, low absorption and bioavailability, as well as high metabolic rate, limit their use for therapeutic purposes [ 23 , 24 , 25 , 26 ]. In fact, the major component curcumin has not been approved as a therapeutic agent yet due to its pharmacokinetics and physicochemical properties, despite it is generally considered a safe substance [ 24 , 27 ].…”

Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome

“…Turmeric contains hundreds of potentially bioactive compounds with curcumin present at 0.4%–7.2% of dry weight [6]. However, curcumin has very low oral bioavailability in rats, due to its hydrophobic nature, rapid metabolism and systemic elimination.…”

Extrato rico em Curcumina do Brasil Central Curcuma longa protege células endoteliais de veias umbilicais humanas sob estresse oxidativo

“…We found an average content of 16.7% curcumin in the EEC, it is known that the curcumin content in the plant can vary due to factors such as soil type, geographic location, climate, spacing between plants, type of mineral fertilizer, rhizome storage period, exposure to light and others [21][22][23] . Ferreira 21 and collaborators reported a 14.83% curcumin content in the rhizome powder obtained from Cooperaçafrão, through extraction by ethanol and analysis by HPLC.…”