Development of Prolonged-Release Systems With Magnolol Based on Silica Sba-15

Ştefanache, Alina

doi:10.5593/sgem2015/b61/s24.008

Cited by 1 publication

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“…Thus, the un-functionalized matrix achieved a prolonged release of MG over 15 h, whereas the functionalized SBA-15 showed capabilities for retardation of release covering over 20 h. These results are consistent with other published results that evidenced an increase in the drug loading capacity of SBA-15 silica. It is important to note that the rate of drug release decreases proportionally with the increase of the loading capacity due to the electrostatic interactions that occur between the functional groups and the drug molecule [23,41]. These results are additionally confirmed by the release kinetics analysis of the mesoporous silica ( Table 2).…”

Section: In Vitro Release Of Mg-loaded Mesoporous Silica and Analysissupporting

confidence: 59%

“…The inorganic drug delivery systems containing MG molecules are developed in order to prolong MG release into the human body. For this purpose, in a previous work, the authors of the present paper have proposed mesoporous silica matrix, SBA-15 type, for the encapsulation of magnolol [23] and demonstrated that SBA-15 silica is a compatible matrix for magnolol in formulating sustained-release drug delivery systems. Our previous study has provided scientific results on the textural, structural and morphological properties of magnolol-encapsulated in mesoporous SBA-15 silica, and showed that the hexagonal order of SBA-15 mesopores is conserved after the encapsulation of magnolol.…”

Section: Introductionmentioning

confidence: 94%

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Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

et al. 2017

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Magnolol (MG) is a small-molecule neolignan polyphenolic compound isolated from the genus Magnolia. The anti-inflammatory, anti-oxidative, anti-diabetic, anti-tumorgenic, anti-neurodegenerative, anti-depressant and anti-microbial properties of MG are well documented in recent literature. These fascinating multiple biological activities of MG encourage research about the development of new delivery and administration approaches able to maximize its potential benefits. This study describes the amino-functionalization of the SBA-15 (Santa Barbara Amorphous) mesoporous matrix by post-synthesis grafting using APTES (3-aminopropyltriethoxysilane) and the characterization of amino-functionalized mesoporous silica SBA-15 loaded with MG in order to achieve modified drug delivery systems. The amino-functionalization of silica SBA-15 was carried out by grafting by refluxing in dry toluene. The powders obtained were characterized texturally by Brunauer-Emmett-Teller (BET) surface area analysis measurements and morphologically by scanning electron microscopy. MG loading degree in the nanoporous matrix was determined by the HPLC method at λ = 290 nm. Results showed that by grafting the amino groups in the silica SBA-15, we obtained amino-functionalized silica SBA-15 with an ordered structure, with specific surfaces and pore sizes that differ from the original matrix, which was reflected in the amount of MG immobilized and release kinetics profile.

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Section: In Vitro Release Of Mg-loaded Mesoporous Silica and Analysissupporting

confidence: 59%

Section: Introductionmentioning

confidence: 94%