Development of regulation of melatonin release in pineal cells in chick embryo

Akasaka, Keishiro; Nasu, Tetsuo; Katayama, Tetsuro; Murakami, Noboru

doi:10.1016/0006-8993(95)00643-5

Cited by 47 publications

(43 citation statements)

References 12 publications

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“…The regulation of MLT synthesis by light acting via pineal photoreceptive structures was found for the first time in 13-14-day-old chick embryos (Akasaka et al 1995, Lamosová et al 1995, Csernus et al 2007). It has been demonstrated that the control of MLT secretion by the intrapineal circadian oscillator is switched on slightly later, about day 18 of embryonic life (Akasaka et al 1995). The daily rhythm of arylalkylamine N-acetyltransferase (AA-NAT) activity was found in the pineal organs of 16-day-old chick embryos (Herichová et al 2001).…”

Section: Discussionmentioning

confidence: 91%

“…The release of trace amounts of MLT from the chicken pineal organ in vitro was detected as early as on the day 11 of embryonic life, and a large increase in the secretion level was observed during the subsequent days of development (Möller and Möller 1990). The regulation of MLT synthesis by light acting via pineal photoreceptive structures was found for the first time in 13-14-day-old chick embryos (Akasaka et al 1995, Lamosová et al 1995, Csernus et al 2007). It has been demonstrated that the control of MLT secretion by the intrapineal circadian oscillator is switched on slightly later, about day 18 of embryonic life (Akasaka et al 1995).…”

Section: Discussionmentioning

confidence: 93%

“…The glands of 3-week-old birds demonstrated a faster accommodation to the reversed light regime, as MLT secretion peaked on the second day of the experiment. Pineal cells of 13-and 14-day-old chick embryos secreted MLT in a reversed pattern already on the first day of the culture under a 12D:12L cycle (Akasaka et al 1995). However, it should be stressed that an endogenous oscillator starts to control MLT secretion in the chicken pineal on the day 18 of embryonic development and the lack of a circadian regulation in pinealocytes of 13-and 14-day-old embryos probably creates favorable conditions for quick adaptation of the secretory activity to changes in illumination.…”

Section: Discussionmentioning

confidence: 96%

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Regulation of melatonin secretion in the pineal organ of the domestic duck – an in vitro study

Prusik¹,

Lewczuk²,

Ziółkowska³

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of study was to determine the mechanisms regulating melatonin secretion in the pineal organs of 1-day-old and 9-month-old domestic ducks. The pineals were cultured in a superfusion system under different light conditions. Additionally, some explants were treated with norepinephrine.The pineal glands of 1-day-old ducks released melatonin in a well-entrained, regular rhythm during incubation under a 12 hrs light : 12 hrs dark cycle and adjusted their secretory activity to a reversed 12 hrs dark : 12 hrs light cycle within 2 days. In contrast, the diurnal changes in melatonin secretion from the pineals of 9-month-old ducks were largely irregular and the adaptation to a reversed cycle lasted 3 days. The pineal organs of nestling and adult ducks incubated in a continuous light or darkness secreted melatonin in a circadian rhythm. The treatment with norepinephrine during photophases of a light-dark cycle resulted in: 1) a precise adjustment of melatonin secretion rhythm to the presence of this catecholamine in the culture medium, 2) a very high amplitude of the rhythm, 3) a rapid adaptation of the pineal secretory activity to a reversed light-dark cycle. The effects of norepinephrine were similar in the pineal organs of nestlings and adults.In conclusion, melatonin secretion in the duck pineal organ is controlled by three main mechanisms: the direct photoreception, the endogenous generator and the noradrenergic transmission. The efficiency of intra-pineal, photosensitivity-based regulatory mechanism is markedly lower in adult than in nestling individuals.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

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Regulation of melatonin secretion in the pineal organ of the domestic duck – an in vitro study

Prusik¹,

Lewczuk²,

Ziółkowska³

et al. 2015

Polish Journal of Veterinary Sciences

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“…Thus, if melatonin is to play any role in avian embryonic development it should either be accumulated in the oocyte or synthesised very early by the embryonic cells. The earliest melatonin synthesis was detected in pineal cells isolated from 10-and 13-days old chick embryos (Akasaka et al, 1995;Moller and Moller, 1990), and this corresponds to the stage when the embryonic pineal gland acquires its vesicular structure (Jove et al, 1999). The presence of serotonin -the substrate of melatonin synthesis -in chicken yolk has been reported previously (Emmanuelsson et al, 1988;Moudgal et al, 1992).…”

Section: Presence and Possible Role Of Serotonin And Melatonin In Earmentioning

confidence: 59%

Molecular aspects of avian oogenesis and fertilisation

Olszańska¹,

Stępińska²

2008

Int. J. Dev. Biol.

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In this paper, we summarise studies which have been carried out on the metabolism of nucleic acids (maternal RNA, DNA, nucleolytic enzymes) in avian oocytes and embryos (Japanese quail, Coturnix coturnix japonica ) within the last 10 years in the Institute of Genetics and Animal Breeding of the Polish Academy of Sciences. The accumulation of maternal RNA in the quail oocyte during oogenesis is shown and discussed. Several individual transcripts were identified in RNA from the germinal disc and some also in extraembryonic RNA under the perivitelline membrane. The presence of the transcript encoding chick zona pellucida C protein (chZPC) points to the possibility of ZPC synthesis by the oocyte itself. The transcript encoding AA-NAT (arylalkylamine N-acetyltransferase, the penultimate enzyme in melatonin synthesis) was present in 2 forms (with and without an intron) and the ratio of the two forms changes during oogenesis. Melatonin and the two enzymes engaged in its synthesis (AA-NAT and HIOMT) have been found in the egg yolk; their transcripts and the transcripts of the melatonin receptors mel1a,b and c are present in RNA from the germinal discs. This suggests a possible role for melatonin in early avian development. DNases I and II activity has been detected in the germinal disc and the cytoplasmic layer under the perivitelline membrane. We propose that they participate in degradation of supernumerary sperm entering avian oocytes during polyspermic fertilisation. A hypothesis to explain the selection of a single sperm participating in the formation of the zygotic nucleus is discussed; we propose that sperm entry into the centre of the germinal disc is the essential event underlying the selection mechanism.

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“…A subsequent increase of melatonin content is observed between embryonic day 19 and post-embryonic day 3 (Herichová et al 2001). Circadian production of melatonin under in vitro conditions was confirmed at day 14 of ED (Akasaka et al 1995) and at day 16 (Lamo‰ová et al 1995). Rhythmic melatonin synthesis was observed also in embryos of another precocial bird species, the Japanese quail .…”

mentioning

confidence: 83%

Embryonic and Post-Embryonic Development of Japanese Quail after In Ovo Melatonin Treatment

Z.¹,

Kuncová²,

Lamošová³

et al. 2003

Acta Vet. Brno

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The effect of exogenous melatonin on embryonic and post-embryonic development of quail was analysed. Japanese quail (Coturnix coturnix japonica) eggs were incubated under standard conditions and light regime L12:D12. At incubation day 5 eggs were treated with 5, 50 or 250 m g of melatonin per egg and at incubation day 10 with 50 or 250 m g melatonin/egg. Melatonin was injected into eggs in 50 m l of sterile saline containing maximum 5% of ethanol. Fertility and hatchability of eggs were recorded. Hatchlings were inspected for gross developmental aberrations and killed by decapitation during post-embryonic day 1, 2 and 3 in the middle of the scotophase and photophase. Plasma and pineal glands were collected and melatonin levels were measured in both materials by radioimmunoassay. Weights of the liver, spleen and bursa of Fabricius were recorded at postembryonic day 1, 2 and 3. Plasma melatonin levels were increased in melatonin treated groups in comparison with control group at day 1 and 2. High hormone levels persisted until post-hatching day 2. These findings suggest that melatonin was not metabolized efficiently during the embryonic period and embryos were under melatonin influence during embryonic development. Administration of melatonin did not affect pineal melatonin levels. No developmental malformations were found in treated birds. Hatchability and weights of organs did not differ between the melatonin -treated and control groups. Melatonin, quail, development, embryoMelatonin, produced by the pineal gland, is involved in the control of circadian rhythms.

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Development of regulation of melatonin release in pineal cells in chick embryo

Cited by 47 publications

References 12 publications

Regulation of melatonin secretion in the pineal organ of the domestic duck – an in vitro study

Regulation of melatonin secretion in the pineal organ of the domestic duck – an in vitro study

Molecular aspects of avian oogenesis and fertilisation

Embryonic and Post-Embryonic Development of Japanese Quail after In Ovo Melatonin Treatment

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