Development of scientifically justified proposals on the prevention and treatment of environmentally determined constitutional growth delay in children in the West Kazakhstan region

Жумалина, А К; Бекмухамбетов, Е Ж; Тусупкалиев, Б Т; Zharlikasinova, Mairamkul B

doi:10.1007/s10653-018-0210-0

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…For example, a prospective cohort study by Peng et al 33 found that maternal urinary Cr concentrations in the first 3 months of gestation were negatively correlated with fetal growth parameters at 31 weeks of gestation. Meanwhile, a study in Kazakhstan 34 found that high levels of Cr in the blood may cause growth retardation in children, whereas some studies did not find there were correlations between Cr and children's growth and development. 35,36 Cr mainly exists in two stable forms: Cr (III) and Cr (VI).…”

Section: Discussionmentioning

confidence: 99%

Association Between Heavy Metals Exposure and Height in Chinese Preschoolers

et al. 2023

J Occup Environ Med

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Objectives This study aimed to explore the association between multiple metals' exposure and children's height. Methods We collected urine samples and physical measurement data of 1477 preschoolers in China. Children's actual height was measured, and whether reached target height was also assessed. Logistic regression analysis was performed to explore the association between heavy metals and height. The least absolute shrinkage and selection operator regression was used to select the urinary metals, which were highly correlated. Results In the single-metal model after adjusting for potential confounders, urinary iron, aluminum, nickel, chrome, titanium, vanadium, selenium, rubidium, and thallium levels were negatively associated with actual height. Urinary iron, aluminum, nickel, and chrome concentrations were also negatively associated with target height. Conclusions The findings suggested that some urinary metal exposure might be associated with height in preschoolers.

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Section: Discussionmentioning

confidence: 99%

Association Between Heavy Metals Exposure and Height in Chinese Preschoolers

et al. 2023

J Occup Environ Med

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“…Exposed boys and girls in West Kazakhstan, aged 7-17 years, exhibited a retardation in annual height increase and body weight gain compared to children from a control area [57]. In children with short stature, an imbalance in hormonal status was observed based on a lack of activation of thyroid-stimulating hormones, as well as insufficient levels and an impaired ratio of gonadotropins [57]. Neuropsychological impairment was correlated with urinary and hair Cr levels in 393 children aged 6-11 years [58].…”

Section: Cr Exposure and Health Outcomes In Childhoodmentioning

confidence: 90%

Section: Cr Exposure and Health Outcomes In Childhoodmentioning

confidence: 99%

“…Exposure to chromium has been implicated in growth delay [57] and suppression of neurophysiological development in school-age children [58]. Exposed boys and girls in West Kazakhstan, aged 7-17 years, exhibited a retardation in annual height increase and body weight gain compared to children from a control area [57]. In children with short stature, an imbalance in hormonal status was observed based on a lack of activation of thyroid-stimulating hormones, as well as insufficient levels and an impaired ratio of gonadotropins [57].…”

Section: Cr Exposure and Health Outcomes In Childhoodmentioning

confidence: 99%

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Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence

Sazakli

2024

IJERPH

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The toxicity and carcinogenicity of hexavalent chromium via the inhalation route is well established. However, a scientific debate has arisen about the potential effects of oral exposure to chromium on human health. Epidemiological studies evaluating the connection between ingested chromium and adverse health effects on the general population are limited. In recent years, a wealth of biomonitoring studies has emerged evaluating the associations between chromium levels in body fluids and tissues and health outcomes. This systematic review brings together epidemiological and biomonitoring evidence published over the past decade on the health effects of the general population related to oral exposure to chromium. In total, 65 studies were reviewed. There appears to be an inverse association between prenatal chromium exposure and normal fetal development. In adults, parameters of oxidative stress and biochemical alterations increase in response to chromium exposure, while effects on normal renal function are conflicting. Risks of urothelial carcinomas cannot be overlooked. However, findings regarding internal chromium concentrations and abnormalities in various tissues and systems are, in most cases, controversial. Environmental monitoring together with large cohort studies and biomonitoring with multiple biomarkers could fill the scientific gap.

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“…The geographical location of our research team gives it a special interest in environmental health, since the Aktobe region includes part of the Aral Sea disaster area (Palmerini et al, 2017) and a chromite mining and smelting industry (Zhumalina et al, 2018). Environmental deterioration caused by Aral Sea disaster has created a hazardous situation for the health of approximately 3.5 million people.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Evaluation of Cardiac Angiogenesis of Mice Exposed to Sodium Dichromate and Lindane

Bekmukhambetov¹,

Rakhmanov²,

Zhanabayeva³

2019

Appl. Ecol. Env. Res.

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The immunohistochemical distribution and expression of the three markers in cardiomyocytes were evaluated in three groups of mice: a control group, mice exposed to 5 mg/kg b.w./day sodium dichromate (group A) and mice exposed to 100 mg/kg b.w./day lindane (group B). All mice were sacrificed after 2 months of chronic exposure to the chemicals. Hematoxylin eosin staining revealed thickening of the anterior walls and thinning of the posterior walls of the left ventricle. Anterior and posterior vessel wall densities increased by a factor of about 1.5 in group A and about 2 in group B compared to the control group. Posterior wall vessel diameters declined by a factor of 3.7 in group A and 2.9 in group B. Immunohistochemical staining showed that sodium dichromate was associated with significantly lower expression of CD117 (p = 0.019) and p53 (p = 0.002) than in controls, whereas VEGF expression increased (p = 0.03). In mice exposed to lindane, the results showed an opposite, though not significant trend, namely increased levels of CD117 and p53 and decreased levels of VEGF expression with respect to the control group. We observed significant changes in ventricular wall thickness, vessel density, vascular growth factor expression and mast cell apoptosis, directly correlated with exposure to lindane.

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Development of scientifically justified proposals on the prevention and treatment of environmentally determined constitutional growth delay in children in the West Kazakhstan region

Cited by 8 publications

References 5 publications

Association Between Heavy Metals Exposure and Height in Chinese Preschoolers

Association Between Heavy Metals Exposure and Height in Chinese Preschoolers

Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence

Immunohistochemical Evaluation of Cardiac Angiogenesis of Mice Exposed to Sodium Dichromate and Lindane

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