Development of semicrystalline poly(vinyl alcohol) hydrogels for biomedical applications

Peppas, Nikolaos A.; Merrill, Edward W.

doi:10.1002/jbm.820110309

Cited by 199 publications

(102 citation statements)

References 18 publications

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“…As a hydrophilic polymer, PVA exhibits excellent water retention properties. 9 Optimum solubility occurs at 87% to 89% hydrolysis. For total dissolution, however, PVA requires water temperatures of~100-C with a hold time of 30 minutes.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

2007

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The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as solution) was compared with the mixture of PVA and gelatin of the same composition. The mechanical properties of the hydrogels were characterized by tensile tests. Swelling behavior and hemocompatibility of the membrane were also evaluated. The diffusion coefficient of salicylic acid (SA), when the receptor compartment contained Ringer's solution, through the membrane was determined. SA was used as a model drug. FTIR spectra of the membranes indicated complete esterification of the free carboxylic groups of gelatin. XRD studies indicated that the crystallinity of the membranes was mainly due to gelatin. The comparison of viscosity indicated an increase in segment density within the molecular coil. The membrane had sufficient strength and water-holding capacity. Hemocompatibility suggested that the hydrogel could be tried as wound dressing and as an implantable drug delivery system. The diffusion coefficient of SA through the membrane was found to be 1.32 × 10 −5 cm 2 /s. The experimental results indicated that the hydrogel could be tried for various biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

2007

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“…The first attempt to use PVA-H as an artificial cartilage is credited to Peppas and co-workers, 21,22 although it has been recognized as one of the materials for biomedical application. As early as 1975, Peppas and Merrill 21 had succeeded in synthesizing strong hydrogels by a freezing-thawing process.…”

Section: Discussionmentioning

confidence: 99%

Attachment of artificial cartilage to underlying bone

et al. 2003

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The key problem with artificial joint materials is obtaining quick and firm attachment onto the underlying bone. In developing artificial articular cartilage, composed of polyvinyl alcohol hydrogel (PVA-H), this problem was solved by using a composite osteochondral device (COD). This enables attachment within four weeks post-operation by massive bone ingrowth into the pores. The COD consists of PVA-H as an artificial cartilage and titanium fiber mesh (TFM) as porous artificial bone. In this study, the strength of the shear resistance force at the interface of the PVA-H and the TFM fabricated by injection molding and the changes in the mechanical properties of the PVA-H fabricated by high temperature during the injection-molding process were examined. The shear resistance force was strengthened markedly by using injection molding and no important deterioration of the PVA-H was found. Morphological examination of canine spines, to which artificial intervertebral discs made of the COD were implanted, showed good bonding of the COD with the vertebral bodies for an extended period of 30 months, and encouraged us to use the COD clinically.

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“…The reasons for these complications are not fully understood but may be related to the material properties of PHEMA networks. Despite being classified as a hydrophilic polymer, PHEMA is still relatively hydrophobic compared to other hydrogels such as poly(vinyl alcohol), which can attain an equilibrium water content of over 80% (42,43). Hydrophobicity makes materials more susceptible to nonspecific protein adsorption, which has been proposed to be the molecular event that triggers calcification (38).…”

Section: Hydrogel Keratoprosthesesmentioning

confidence: 99%

Development of Hydrogel‐Based Keratoprostheses: A Materials Perspective

Myung

Duhamel

Cochran

et al. 2008

Biotechnology Progress

105

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Research and development of artificial corneas (keratoprostheses) in recent years have evolved from the use of rigid hydrophobic materials such as plastics and rubbers to hydrophilic, waterswollen hydrogels engineered to support not only peripheral tissue integration but also glucose diffusion and surface epithelialization. The advent of the AlphaCor core-and-skirt hydrogel keratoprosthesis has paved the way for a host of new approaches based on hydrogels and other soft materials that encompass a variety of materials preparation strategies, from synthetic homopolymers and copolymers to collagen-based bio-copolymers and, finally, interpenetrating polymer networks. Each approach represents a unique strategy toward the same goal: to develop a new hydrogel that mimics the important properties of natural donor corneas. We provide a critical review of these approaches from a materials perspective and discuss recent experimental results. While formidable technical hurdles still need to be overcome, the rapid progress that has been made by investigators with these approaches is indicative that a synthetic donor cornea capable of surface epithelialization is now closer to becoming a clinical reality.

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Development of semicrystalline poly(vinyl alcohol) hydrogels for biomedical applications

Cited by 199 publications

References 18 publications

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications

Attachment of artificial cartilage to underlying bone

Development of Hydrogel‐Based Keratoprostheses: A Materials Perspective

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