The paper focuses on the changes to the industrial structure of small Moravian towns as these towns are part of the settlement structure that connects urban and rural systems. Small towns (of up to 15,000 inhabitants) are the most industrialized part of the Czech settlement system. They were the subject of capitalist industrialization in the nineteenth and early twentieth centuries, as well as socialist industrialization in the second half of the twentieth century. Therefore, the research question asks how the small-town sector coped with the transition to a post-productive society and how small towns were differentiated during this process. Population censuses were the main tool used to gather data for comparison. Today, small towns have preserved, in particular, less innovatively demanding industries, which have been pushed out of large and medium-sized cities. At the same time, they are undergoing a process of post-productive transformation which is associated with a massive transfer of job opportunities to services, but they can also become starting points for cultural tourism in rural areas. However, their future development will be very differentiated depending on their location concerning regional centres, on the quality of human and social capital and also on their historical pathways.