Development of smart alginate/chitosan grafted microcapsules for colon site-specific drug delivery

Omer, Ahmed M.; Taher, M. A.; Hamed, A. M.; Ali, Adnan; Tamer, T.M.; Eldin, M.S. Mohy

doi:10.21608/ejchem.2019.6716.1562

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…In Figure 6 I, the lower concentration of CS caused a decrease in EE%, which may be attributable to the effects of the CS content on the formulation diameter and EE% [ 22 ]. A rise in the concentration of CS in the coagulation solution results in the production of a denser membrane due to an increase in the number of alginate-CS ionic bonds, which decreases the porosity of the gel structure and causes an increase in drug entrapment simultaneously.…”

Section: Resultsmentioning

confidence: 99%

Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers

et al. 2023

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This study aimed to formulate a pharmaceutical dosage form containing omeprazole (OMP) and curcumin (CURC) to treat experimental peptic ulcers. OMP and CURC were preliminarily complexed with hydroxypropyl-β-cyclodextrin for enhancing their solubilization. After that, the combined complex (CURC/OMP) was loaded to alginate beads to sustain their release and then coated with chitosan. Finally, we tested the anti-ulcerogenic impact of the best formula versus free OMP or OMP-only-loaded beads. The formulated spherical beads’ diameter ranged from a minimum value of 1.5 ± 0.08 mm to 2.6 ± 0.24 mm; the swelling results ranged from 400.00 ± 8.5% to 800.00 ± 6.2%. The entrapment efficiency was in a range from 60.85 ± 1.01% to 87.44 ± 1.88%. The optimized formula (F8) showed a maximum EE% (87.44 ± 1.88%), swelling (800.00 ± 6.2%), and diameter in the range of 2.60 ± 0.24, with a desirability of 0.941. In the first hour following the administration of the free drug complex, 95% of OMP and 98% of CURC were released. This is unacceptable for medications that require a delayed release in the stomach. The initial drug release from hydrogel beads was 23.19% for CURC and 17.19% for OMP after 2 h and 73.09% for CURC and 58.26% for OMP after 12 h; however, after 24 h, 87.81% of CURC and 81.67% of OMP had been released. The OMP/CURC beads showed a more stable particle size (0.52 ± 0.01 mm) after 6 weeks. In conclusion, the OMP/CURC hydrogel beads give stronger anti-ulcer effectiveness compared to free OMP, CURC-only beads, and OMP-only-loaded beads, indicating a prospective application for managing peptic ulcers.

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Section: Resultsmentioning

confidence: 99%

Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers

et al. 2023

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“…Every two hours, the beads were taken out, blotted using filter papers to eliminate the excess amounts of the buffer, and the weight of the beads was recorded until they reached equilibrium. We calculated the degree of swelling by applying Equation (1) [ 34 ]:

…”

Section: Methodsmentioning

confidence: 99%

Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination for Colon-Specific Drug Delivery

Heikal

Kaoud

Gad

et al. 2023

Gels

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This research aims to develop a drug delivery system that effectively treats colitis while administering curcumin/mesalamine by coating alginate/chitosan beads with Eudragit® S-100 to target the colon. Beads were tested to determine their physicochemical characteristics. Coating with Eudragit® S-100 prevents drug release at a pH of less than 7; this was demonstrated by in-vitro release conducted in a medium with gradually varying pH to mimic circumstances in various regions of the gastrointestinal tract. This study examined the efficacy of the coated beads in treating acetic acid-induced colitis in rats. Results showed that spherical beads were formed with an average diameter of 1.6–2.8 mm, and the obtained swelling ranged from 409.80% to 890.19%. The calculated entrapment efficiency ranged from 87.49% to 97.89%. The optimized formula F13 (which was composed of mesalamine-curcumin active ingredients, Sodium alginate as a gelling agent, chitosan as a controlled release agent, CaCl2 as a crosslinking agent, and Eudragit S-100 as a pH-sensitive coating agent) demonstrated the best entrapment efficiency (97.89% ± 1.66), swelling (890.19% ± 60.1), and bead size (2.7 ± 0.62 mm). In formulation #13, which was coated with Eudragit S 100, curcumin (6.01 ± 0.04%) and mesalamine (8.64 ± 0.7%), were released after 2 h at pH 1.2; 6.36 ± 0.11% and 10.45 ± 1.52% of curcumin and mesalamine, respectively, were then released after 4 h and at pH 6.8. Meanwhile, at pH 7.4, after 24 h, approximately 85.34 ± 2.3% (curcumin) and 91.5 ± 1.2% (mesalamine) were released. Formula #13 significantly reduced the colitis, and this suggests that the developed hydrogel beads can be used for delivering curcumin-mesalamine combinations to treat ulcerative colitis after adequate research.

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“…Cellulose is reacted with GTMAC [13], chitosan is connected with GTMAC [14], p-aramid fibers are attached to GTMAC [15], and poly(ethylene glycol)-diacrylate (PEGDA), trimethylolpropane-tri-acrylate (TMPTA), and trimethylolpropane tris(3mercaptopropionate) (TMPTMP) crosslinked with GTMAC [16]. Among these polymeric materials, chitosan is the most promising and abundant material due to its biodegradability, biocompatibility, and nontoxicity [17]. The cationic character of chitosan on its surface can be shown in neutral conditions.…”

Section: ■ Introductionmentioning

confidence: 99%

Preparation and Characterization of Magnetic Material/Chitosan Composite Modified with Glycidyl-Trimethylammonium Chloride

Mukhayani,

Kunarti,

Kamiya

et al. 2024

Indones. J. Chem.

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Glycidyl-trimethylammonium chloride (GTMAC) containing quaternary ammonium (QA) groups is commonly used as a base catalyst for any organic reaction. This research prepared a novel composite of GTMAC attached to chitosan-coated magnetic material (MM/Chi/GTMAC) using a precipitation method. The effect of chitosan and GTMAC contents on MM/chi/GTMAC properties was studied, where the chitosan content varied from 0, 0.3, 0.5, 1.0, and 3.0 mol, and GTMAC varied from 0, 0.3, 0.8, 1.0, 1.5, and 3 mL with the constant mass of MM (0.4640 g). The physicochemical and morphological properties were characterized with FTIR, SEM-EDX, XRD, TGA, UV-vis, AAS, and zeta-sizer, and the magnetic strength was simply tested with an external magnet. The result showed that a mixture containing chitosan and GTMAC of 0.358 g and 1.5 mL was an optimum composition, in which MM/chi(0.5)/GTMAC(1.5) has high thermal stability, low chitosan and Fe solubility, and optimum content of QA (0.284 mol/g) without loss of magnetic strength. The higher the amount of chitosan, the lower the magnetic properties, and the higher the GTMAC did not increase the QA content. Therefore, the composite produced has the potential to be a novel heterogeneous base catalyst that is quickly recovered from any organic reaction media.

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Development of smart alginate/chitosan grafted microcapsules for colon site-specific drug delivery

Cited by 7 publications

References 18 publications

Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers

Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers

Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination for Colon-Specific Drug Delivery

Preparation and Characterization of Magnetic Material/Chitosan Composite Modified with Glycidyl-Trimethylammonium Chloride

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