Development of smart delivery system for ascorbic acid using pH-responsive P(MAA-co-EGMA) hydrogel microparticles

Eun-Mi, Lee; Kim, Kyusik; Choi, Moon-Jae; Lee, Young Moo; Park, Jin Won; Kim, Bumsang

doi:10.3109/10717544.2010.500636

Cited by 12 publications

(6 citation statements)

References 14 publications

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“…The results indicated a higher mode of insulin release in aqueous medium owing to the reduced mass transfer resistance of the protein in the imprinted matrix. The effect of the polymer mixture in this work was in agreement with the previous study of MAA and in the polyethylene glycol-based hydrogel (37,38) enabling the interaction with the receptor on the membrane subsequent to insulin release to the medium. Nonetheless, the proximity of the protein receptor or the dense packing of the amino acid groups affected the insulin structure within imprints, as determined by confocal Raman spectroscopy, favoring the interaction of the insulin at its binding site surrounded by the crosslinked chains.…”

Section: In Vitro Release Studiessupporting

confidence: 80%

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

2017

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In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.

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Section: In Vitro Release Studiessupporting

confidence: 80%

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

2017

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“…With its homogeneity, high stability over time, and high drug release under NIR light irradiation, the Boc-γ 4 ( R )Phe-γ 4 ( R )Phe-OH + GO hydrogel is the most suitable gel for controlled drug release applications. l -Ascorbic acid has been also incorporated in other types of hydrogels, mainly constituted of pH- or thermo-responsive (bio)polymers [ 50 , 51 ]. The release of the drug was spontaneous at 37 °C [ 51 ], or triggered by changing pH [ 50 ], but it reached lower percentages in comparison to our photoresponsive hydrogels.…”

Section: Resultsmentioning

confidence: 99%

“…l -Ascorbic acid has been also incorporated in other types of hydrogels, mainly constituted of pH- or thermo-responsive (bio)polymers [ 50 , 51 ]. The release of the drug was spontaneous at 37 °C [ 51 ], or triggered by changing pH [ 50 ], but it reached lower percentages in comparison to our photoresponsive hydrogels.…”

Section: Resultsmentioning

confidence: 99%

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

et al. 2022

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Peptide-based hydrogels are considered of special importance due to their biocompatibility and biodegradability. They have a wide range of applications in the biomedical field, such as drug delivery, tissue engineering, wound healing, cell culture media, and biosensing. Nevertheless, peptide-based hydrogels composed of natural α-amino acids are limited for in vivo applications because of the possible degradation by proteolytic enzymes. To circumvent this issue, the incorporation of extra methylene groups within the peptide sequence and the protection of the terminal amino group can increase the enzymatic stability. In this context, we investigated the self-assembly capacity of aromatic dipeptides (Boc-α-diphenylalanine and Boc-α-dityrosine) and their β- and γ-homologues and developed stable hydrogels. Surprisingly, only the Boc-diphenylalanine analogues were able to self-assemble and form hydrogels. A model drug, l-ascorbic acid, and oxidized carbon nanotubes (CNTs) or graphene oxide were then incorporated into the hydrogels. Under near-infrared light irradiation, the photothermal effect of the carbon nanomaterials induced the destabilization of the gel structure, which caused the release of a high amount of drug, thus providing opportunities for photocontrolled on-demand drug release.

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“…In the case of polymers [120] that contain acidic groups, when the pH of the medium rises, the degree of polymer ionization increases. In contrast, in the case of polymers that have amino groups in their structure, when the pH of the medium rises, the degree of polymer ionization decreases.…”

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

Polymers and Drug Delivery Systems

Vilar

Tulla‐Puche²,

Alberício³

2012

CDD

243

154

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In the treatment of health related dysfunctions, it is desirable that the drug reaches its site of action at a particular concentration and that this therapeutic dose range remains constant over a sufficiently long period of time to alter the process. However, the action of pharmaceutical agents is limited by various factors, including their degradation, their interaction with other cells, and their incapacity to penetrate tissues as a result of their chemical nature. For these reasons, new formulations are being studied to achieve a greater pharmacological response; among these, polymeric systems of drug carriers are of high interest. These systems are an appropriate tool for time- and distribution-controlled drug delivery. The mechanisms involved in controlled release require polymers with a variety of physicochemical properties. Thus, several types of polymers have been tested as potential drug delivery systems, including nano- and micro-particles, dendrimers, nano- and micro-spheres, capsosomes, and micelles. In all these systems, drugs can be encapsulated or conjugated in polymer matrices. These polymeric systems have been used for a range of treatments for antineoplastic activity, bacterial infections and inflammatory processes, in addition to vaccines.

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Development of smart delivery system for ascorbic acid using pH-responsive P(MAA-co-EGMA) hydrogel microparticles

Cited by 12 publications

References 14 publications

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

Polymers and Drug Delivery Systems

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