Polymers and Drug Delivery Systems

Vilar, Gemma; Tulla‐Puche, Judit; Alberício, Fernando

doi:10.2174/156720112801323053

Cited by 244 publications

(172 citation statements)

References 97 publications

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“…(2) where N is normality of hydrogen bromide (HBr), while v is volume of HBr in mL and w is weight of resin in gram.…”

Section: Characterization Of the Precursor's Physicochemical Propertimentioning

confidence: 99%

“…Polymers are amongst the most extensively explored and widely use materials as drug vehicles for localized and sustained delivery of drug (medication) to a patient [1,2]. There are different types of drug vehicles such as macromolecular carriers (macromolecular prodrugs, protein-macromolecule conjugates and gene medicines complexed with macromolecular carriers), particulate carriers (micro/nanoparticles, liposomes, dendrimers, lipoproteins, nanotubes, micro/nanospheres and micro/nanoemulsions) and cellular carriers (leucocytes, platelets, erythrocytes, nanoerythrocytes, hepatocytes, and fibroblast) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Palm Oil-Based Precursors for Development of Polymeric Delivery System

Tajau

Rohani²,

Isahak³

et al. 2017

MJAS

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The use of precursors from natural based polymers offer a more biocompatible and biodegradable properties in producing polymer drug vehicle compared to drug vehicles made from synthetic polymer precursors, which normally found in high molecular weight (MW). High MW polymer will lead to immunologic inflammatory responses due to their lower biodegradability and higher cytotoxicity compared to low MW that could give smaller particle size, higher solubility, higher release efficiency, non-immunogenic, better biodegradability and lower cytotoxicity. Therefore, this study is aimed to produce valuable precursors, particularly to produce epoxidized palm olein (EPOo) and diol, to be used in the development of a new polymeric drug vehicle with low MW. An EPOo was synthesized via in-situ epoxidizing of palm olein (POo) with peracid and sulfuric acid (H 2 SO 4 ) catalyst. Meanwhile the diol was synthesized using hydroxylation of palm oil-based oleic acid via esterification of oleic acid (OA) with glycerol and 4-dodecylbenzyl sulfonic acid catalyst (DBSA). It was found that both palm oil-based precursors have been successfully synthesized from natural resources of palm oil. Physico-chemical properties of the synthesized precursors showed that the EPOo and the diol possess average molecular weight (MW) between 900-1500 g/mol and hydroxyl functionality between 2 and 3, based on the presence of hydroxyl (O-H) group functionality, showed in the Infra-red (IR) spectra in the range of 3200-3600 cm -1 . These low MW palm oil based-precursors have potential uses for the design and development of new properties of polymeric drug vehicle such as acrylated palm olein (APOo) and polyol polyester, which will produce particle size in the range of 100 -200 nm or smaller with high efficiency drug loading and controlled release profiles.Keywords: drug delivery system, palm oil, polymeric nanoparticle Abstrak Penggunaan pelopor dari polimer semulajadi bagi menghasilkan penyampai ubat polimer mempunyai kelebihan tertentu iaitu ianya bersifat bioserasi dan biodegradasi berbanding sistem penyampai ubat yang dibuat daripada pelopor polimer sintetik, kebiasaannya mempunyai berat molekul (MW) yang tinggi. Polimer dengan MW yang tinggi boleh menyebabkan gerak balas keradangan keimunan akibat kurang keterbiodegradasikan dan kesitotoksikan yang tinggi dibandingkan MW yang rendah yang boleh menghasilkan partikel bersaiz lebih kecil, keterlarutan dan kecekapan perlepasan yang tinggi, tidak imunogen, terbiodegradasi dengan lebih baik dan sitotoksiti yang rendah. Oleh itu, kajian ini bertujuan menghasilkan pelopor yang bersifat istimewa, terutamanya minyak sawit olein terepoksida (EPOo) dan diol yang digunakan dalam membangunkan sistem penyampaian ubat dengan MW yang rendah. EPOo telah disintesis menggunakan pengepoksidaan in-situ minyak sawit olein (POo) dengan perasid dan pemangkin asid sulfurik (H 2 SO 4 ). Sementara itu, diol disintesis menggunakan penghidroksilan minyak sawit oleik menggunakan pengesteran asid oleik (OA) dengan gliserol dan p...

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“…(2) where N is normality of hydrogen bromide (HBr), while v is volume of HBr in mL and w is weight of resin in gram.…”

Section: Characterization Of the Precursor's Physicochemical Propertimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Palm Oil-Based Precursors for Development of Polymeric Delivery System

Tajau

Rohani²,

Isahak³

et al. 2017

MJAS

View full text Add to dashboard Cite

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“…However, a burst release of drug was found prevalent in these polymeric matrixes leading to potentially serious consequences for the patients. The improved polymeric matrixes were developed, but feedback-controlled release and other problems with many polymeric DDS limited their practical application (Kumari et al, 2010;Mora-Huertas et al, 2010;Vilar et al, 2012;Sood et al, 2014).…”

Section: Rationale For Mips Application In Ddsmentioning

confidence: 99%

Molecular imprinted polymers as drug delivery vehicles

Zaidi

2014

Drug Delivery

111

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This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).

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“…They can be used in drug-delivery systems [1], for artificial body implants (vascular grafts, stents and heart valves), as scaffolds for ligament and tendon repair, for urinary and vascular catheters, dialysis membranes, orthopedic implants, etc. [2].…”

Section: Introductionmentioning

confidence: 99%

Endothelialization of Polyethylene Terephthalate Treated in SO2 Plasma Determined by the Degree of Material Cytotoxicity

Vesel¹,

Recek²,

Motaln³

2017

Plasma

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Improving the biocompatibility of polyethylene terephthalate (PET) vascular grafts is an important task for avoiding thrombus formation. Therefore, SO 2 plasma at various treatment periods were used to modify PET surface properties by forming sulfate functional groups. These groups were shown to act antithrombogenically, ensuring good hemocompatibility of the materials, although the biocompatibility of such materials still remains a mystery. For this reason, the adhesion and viability of HUVEC cells on SO 2 plasma-modified PET surfaces were studied, and the possible toxicity of the tested material was determined using two different assays, MTT (metabolic activity assay) and SRB (in-vitro toxicology assay). Changes in chemical composition, morphology and wettability were determined as well. Improved endothelialization was observed for all plasma-treated samples, with the most optimal being the sample treated for 80 s, which can be explained by it having the best combination of surface functionalization, roughness and morphology. Furthermore, toxicity was observed to some extent on the sample treated for 160 s, indicating the lowest cell density among the plasma-treated samples. X-ray photoelectron spectroscopy showed increased oxygen and sulfur content on the surface, which was independent on treatment time. Surface roughness of the plasma-treated samples increased, reaching its maximum after 80 s of treatment, and decreased thereafter.

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Polymers and Drug Delivery Systems

Cited by 244 publications

References 97 publications

Palm Oil-Based Precursors for Development of Polymeric Delivery System

Palm Oil-Based Precursors for Development of Polymeric Delivery System

Molecular imprinted polymers as drug delivery vehicles

Endothelialization of Polyethylene Terephthalate Treated in SO2 Plasma Determined by the Degree of Material Cytotoxicity

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