Development of Spherical Crystals of Acetylsalicylic Acid for Direct Tablet-making.

Goczo, Hajnalka; Szabó‐Révész, Piroska; Farkas, Bálint; Hasznos-Nezdei, Magdolna; Serwanis, Serwanis Fahim.; Pintye‐Hódi, Klára; Kasa, Jr.; Erös, I.; Antal, István; Marton, S.

doi:10.1248/cpb.48.1877

Cited by 26 publications

(18 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the applicability of the direct compression for arbutus berry fruits can be easily observed considering the fact that two following conditions are met (Göczo et al 2000): Powder flowability with HR<1.25 (see the added Table 1 These tablets can be used as such and/or as carrier for natural active ingredients from plants. As supported by Madrigal-Carballo et al (2010), the challenge now consists of the incorporation of natural bioactive molecules into dosage forms for preventive and therapeutic applications, knowing that the use of natural materials as drug delivery vehicles arouses interest among scientists, due to numerous advantages like their accessibility (Amin et al 2012).…”

Section: Resultsmentioning

confidence: 99%

Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity

Abbas-Aksil¹,

Salem²

2015

JSM

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity

Abbas-Aksil¹,

Salem²

2015

JSM

View full text Add to dashboard Cite

show abstract

“…The advantages of spherical crystals have recently been noted as enhancing dissolution rate, fluidity, compactibility to form tablets, etc. [19]. In addition, in the pharmaceutical field micron-sized crystals are applicable for poorly water-soluble drugs [20], suspension injection [21], and pulmonary inhalation delivery [22][23][24].…”

Section: Resultsmentioning

confidence: 99%

Microcrystallization of α-lactalbumin

Lee

Kwon

Shin

et al. 2005

Journal of Crystal Growth

View full text Add to dashboard Cite

“…Under controlled conditions, such as solvent composition, temperature regulation, supersaturation generation, or mixing speed, crystallized particles can simultaneously agglomerate into spherical dense agglomerates (16,17). The most commonly used spherical crystallization techniques are spherical agglomeration and quasi-emulsion solvent diffusion.…”

Section: Spherical Crystallizationmentioning

confidence: 99%

Spherical crystallization of drugs

Kovačič¹,

Vrečer²,

Planinšek³

2012

Acta Pharmaceutica

View full text Add to dashboard Cite

The solid state properties of pharmaceutical compounds have a decisive impact on dosage form development, stability, and in vivo performance of the drug. Many pharmaceutical drugs are problematic per se due to their inappropriate physical and mechanical properties and poor aqueous solubility. The micromeritic properties of drug particles, such as shape and size, are of essential importance for the formulation of solid high--dose units (1). The particle size of poorly soluble drugs is always an issue due to its impact on dissolution properties. Micronized drug particles (smaller than 10 mm) have a large specific area and provide a way to improve the dissolution rate (2), but high energy input during the micronization process gives rise to increased free surface energy, electrostatic tendencies, and thus poor flowability and/or compressibility of powders and low bulk density (3), which makes them difficult to use in downstream processing in the pharmaceutical industry such as direct tablet-making or capsule-filling processes. In addition, micronized drug substances tend to agglomerate and the increase in surface area is not always reflected in improved dissolution (4). Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.

show abstract

Development of Spherical Crystals of Acetylsalicylic Acid for Direct Tablet-making.

Cited by 26 publications

References 1 publication

Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity

Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity

Microcrystallization of α-lactalbumin

Spherical crystallization of drugs

Contact Info

Product

Resources

About