Development of squamous cell carcinoma in chronic discoid lupus erythematosus

Millard, L.G.; Barker, Diane

doi:10.1111/j.1365-2230.1978.tb01480.x

Cited by 65 publications

(36 citation statements)

References 9 publications

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“…1,2 Little epidemiologic information about this rare complication is available. We summarize and statistically analyze the data from 58 Chinese patients with DLE-related SCC(s), including one inpatient in our hospital and 57 cases identified by searching PubMed and Chinese literature databases .…”

mentioning

confidence: 98%

Squamous cell carcinoma complicating discoid lupus erythematosus in Chinese patients: Review of the literature, 1964-2010

Tao¹,

Zhang²,

Guo³

et al. 2012

Journal of the American Academy of Dermatology

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confidence: 98%

Squamous cell carcinoma complicating discoid lupus erythematosus in Chinese patients: Review of the literature, 1964-2010

Tao¹,

Zhang²,

Guo³

et al. 2012

Journal of the American Academy of Dermatology

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“…Indeed, its overall incidence is 3.3% [4]. The lower lip is the location most affected by the malignant transformation of the discoid lupus lesion, with a frequency of 83.3% of cases according to Liu [5].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Lower Lip Arising in Discoid Lupus Lesion - A Case Report

Sbai

Eabdenbitsen

Elayoubi

et al. 2018

IJMS

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IntroductionRare examples from the literature report a possible degeneration of mucosal lesions of L.E.C. We report a case of squamous cell carcinoma grafted on a lesion of the lower lip in a patient followed for L.E.C. at the ENT and Maxillo-facial department of Mohamed VI University Hospital of Oujda. Case reportA 47-year-old man, with a notion of photosensitivity, presents an atrophic erythematous-violet plaques in the photo-exposed zones evolving for 20 years, evoking chronic discoid lupus cutaneous without any clinical, biological or radiological sign of systematization. The patient had a painful lower ulcer-budding process that had been evolving for 2 years, with suspected bilateral cervical lymphadenopathy. The biopsy revealed a well-differentiated infiltrating squamous cell carcinoma. A surgical excision oncology is then performed with a labial plasty and an obviously bilateral lymph node. ConclusionThe risk of degeneration of skin lesions of lupus discoid is minimal and rare, although monitoring of lupus scars remains essential, especially in the context where exposure to ultraviolet radiation is added as a predisposing factor for possible malignant transformation, surgical treatment is required at the appearance of suspicious lesions confirmed histologically.

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“…In one study by Millard et al, the incidence was 3.3% among 120 white pa ents with CCLE. 4 The scalp is the most common site involved followed by the lips. Heavy smoking could also be a contribu ng factor.…”

Section: Discussionmentioning

confidence: 99%

“…The scalp is the most common site involved as seen in our pa ent, followed by the lips. 4 Squamous cell carcinoma usually arises in skin damaged by ac nic rays. Exposure to chemicals such as coal tar, soot, arsenic and a variety of oils and dis lla on products is also implicated in its pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

DLE Progressing to Squamous Cell Carcinoma: A Case Report

Karki¹,

Jha

2016

Nepal J Dermatol Venereol & Leprol

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A 90 years female diagnosed as a case of Discoid lupus erythematosus (DLE) developed Squamous cell carcinoma from the lesions over a period of 5 years due to treatment gap and late follow up. Diagnosis was based on clinical aspects (erythematous, nodular and scanty bleeding), dermoscopic features and histopathological examination,the absence of systemic involvement and routine laboratory parameters, which registered all within normal range.SCC in a patient with DLE is rare in Nepalese patients. It is every essential to counsel the diagnosed cases of DLE and warn all patients about all the possible outcomes and compliance with medications should be ensured.

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Development of squamous cell carcinoma in chronic discoid lupus erythematosus

Abstract: Summary Squamous cell carcinoma was seen in five patients with chronic discoid lupus erythematosus during a review of 120 cases seen originally in the years 1958–1962.

Cited by 65 publications

References 9 publications

Squamous cell carcinoma complicating discoid lupus erythematosus in Chinese patients: Review of the literature, 1964-2010

Squamous cell carcinoma complicating discoid lupus erythematosus in Chinese patients: Review of the literature, 1964-2010

Squamous Cell Carcinoma of the Lower Lip Arising in Discoid Lupus Lesion - A Case Report

DLE Progressing to Squamous Cell Carcinoma: A Case Report

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