Development of stem cell therapy for atherosclerosis

Ma, Yun; Gu, Tianhe; He, Siqi; He, Shuya; Jiang, Zhisheng

doi:10.1007/s11010-023-04762-8

Cited by 4 publications

(3 citation statements)

References 107 publications

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“…Nanomaterials and cell therapy are two promising strategies for the further translation of preclinical treatment modalities for CVD into clinical practice. 475,[561][562][563] The spatial structures of biomolecules such as cytokines, chemokines, and microRNA are affected by biological, physical and chemical factors such as biological enzymes, temperature, pH, and ionic strength of the surrounding environment in vivo, and also face problems such as off-target and difficulty in breaking through the biofilm barriers, which to a certain extent hinders the efficacy of drugs. 564,565 Based on the characteristics such as the loading capacity and modifiability, 564,566,567 nanomaterials can achieve the encapsulation and delivery of biomolecules to isolate the environment in vivo, 568 assemble themselves with biomolecules or residues to mitigate off-target effects, 536,569,570 and use material sources with lipidsoluble or positive surface potential properties to help therapeutic drugs cross cell membranes, 571 which provides a solution to obstacles in the clinical translation of drugs.…”

Section: Clinical Progress and Translational Implicationsmentioning

confidence: 99%

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

Chen,

Zhang,

Tang

et al. 2024

Sig Transduct Target Ther

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The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages play an essential role in initial inflammatory response that occurs following cardiovascular injury, thereby inducing subsequent damage while also facilitating recovery. Meanwhile, the diverse phenotypes and phenotypic alterations of macrophages strongly associate with distinct types and severity of cardiovascular diseases, including coronary heart disease, valvular disease, myocarditis, cardiomyopathy, heart failure, atherosclerosis and aneurysm, which underscores the importance of investigating macrophage regulatory mechanisms within the context of specific diseases. Besides, recent strides in single-cell sequencing technologies have revealed macrophage heterogeneity, cell–cell interactions, and downstream mechanisms of therapeutic targets at a higher resolution, which brings new perspectives into macrophage-mediated mechanisms and potential therapeutic targets in cardiovascular diseases. Remarkably, myocardial fibrosis, a prevalent characteristic in most cardiac diseases, remains a formidable clinical challenge, necessitating a profound investigation into the impact of macrophages on myocardial fibrosis within the context of cardiac diseases. In this review, we systematically summarize the diverse phenotypic and functional plasticity of macrophages in regulatory mechanisms of cardiovascular diseases and unprecedented insights introduced by single-cell sequencing technologies, with a focus on different causes and characteristics of diseases, especially the relationship between inflammation and fibrosis in cardiac diseases (myocardial infarction, pressure overload, myocarditis, dilated cardiomyopathy, diabetic cardiomyopathy and cardiac aging) and the relationship between inflammation and vascular injury in vascular diseases (atherosclerosis and aneurysm). Finally, we also highlight the preclinical/clinical macrophage targeting strategies and translational implications.

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Section: Clinical Progress and Translational Implicationsmentioning

confidence: 99%

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

Chen,

Zhang,

Tang

et al. 2024

Sig Transduct Target Ther

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“…Atherosclerosis is a group of senile diseases, which is associated with age and premature biological aging. Moreover, there is a growing evidence that organismal and cellular senescence promote atherosclerosis [ 221 ], induced by lipid deposition and inflammation [ 222 – 224 ]. Atherosclerosis usually causes to the occurrence of CVDs, which has a great threat to human health.…”

Section: Overview Of Senescencementioning

confidence: 99%

“…Atherosclerosis usually causes to the occurrence of CVDs, which has a great threat to human health. The vascular damage repair and inflammatory inhibition effects of MSCs make them widely used in the treatment of atherosclerotic diseases [ 222 , 225 – 227 ]. Atherosclerosis is a vascular complication of diabetes.…”

Section: Overview Of Senescencementioning

confidence: 99%

Application of mesenchymal stem cells for anti-senescence and clinical challenges

Wang,

Gao,

Wang

2023

Stem Cell Res Ther

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Senescence is a hot topic nowadays, which shows the accumulation of senescent cells and inflammatory factors, leading to the occurrence of various senescence-related diseases. Although some methods have been identified to partly delay senescence, such as strengthening exercise, restricting diet, and some drugs, these only slow down the process of senescence and cannot fundamentally delay or even reverse senescence. Stem cell-based therapy is expected to be a potential effective way to alleviate or cure senescence-related disorders in the coming future. Mesenchymal stromal cells (MSCs) are the most widely used cell type in treating various diseases due to their potentials of self-replication and multidirectional differentiation, paracrine action, and immunoregulatory effects. Some biological characteristics of MSCs can be well targeted at the pathological features of aging. Therefore, MSC-based therapy is also a promising strategy to combat senescence-related diseases. Here we review the recent progresses of MSC-based therapies in the research of age-related diseases and the challenges in clinical application, proving further insight and reference for broad application prospects of MSCs in effectively combating senesce in the future.

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Proteomic characterization of hUC-MSC extracellular vesicles and evaluation of its therapeutic potential to treat Alzheimer’s disease

Li,

Zhang,

Liu

et al. 2024

Sci Rep

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In recent years, human umbilical cord mesenchymal stem cell (hUC-MSC) extracellular vesicles (EVs) have been used as a cell replacement therapy and have been shown to effectively overcome some of the disadvantages of cell therapy. However, the specific mechanism of action of EVs is still unclear, and there is no appropriate system for characterizing the differences in the molecular active substances of EVs produced by cells in different physiological states. We used a data-independent acquisition (DIA) quantitative proteomics method to identify and quantify the protein composition of two generations EVs from three different donors and analysed the function and possible mechanism of action of the proteins in EVs of hUC-MSCs via bioinformatics. By comparative proteomic analysis, we characterized the different passages EVs. Furthermore, we found that adaptor-related protein complex 2 subunit alpha 1 (AP2A1) and adaptor-related protein complex 2 subunit beta 1 (AP2B1) in hUC-MSC-derived EVs may play a significant role in the treatment of Alzheimer's disease (AD) by regulating the synaptic vesicle cycle signalling pathway. Our work provides a direction for batch-to-batch quality control of hUC-MSC-derived EVs and their application in AD treatment.

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Development of stem cell therapy for atherosclerosis

Cited by 4 publications

References 107 publications

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

Application of mesenchymal stem cells for anti-senescence and clinical challenges

Proteomic characterization of hUC-MSC extracellular vesicles and evaluation of its therapeutic potential to treat Alzheimer’s disease

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