Development of Strengthened Bioactive Calcium Phosphate-Silicate Glass Ceramics for Bone Implants

Саввова, О. В.; Shymon, Vasyl; Фесенко, Олексій; Бабіч, Олена Вікторівна; Alfeldii, Serhii

doi:10.23939/chcht14.01.109

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…All materials used for bone prosthetics and maxillofacial surgery can be divided into 5 main groups: metals and their alloys [2]; glass [3] and glass-ceramic materials [4,5]; composite materials and coatings [6,7]; ceramic and polymeric materials, each of which has its own advantages and disadvantages [8].…”

Section: Introductionsmentioning

confidence: 99%

Biocompatible Glass-Ceramic Scaffolds for Bone Endoprosthetics

Fesenko,

Babich,

Savvova

et al. 2022

InterConf+

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The most modern materials for endoprosthesis replacement of large bone tissues are scaffolds, which allow to completely imitate the structure of the lost bone. Based on the analysis of the classification of materials for endoprosthetics and technologies for their synthesis, the relevance of creating biocompatible glass-ceramic scaffolds by duplicating the polymer matrix was determined. The initial glass (with the content of hydroxyapatite crystals) was selected, and the optimal slip composition and technological parameters of synthesis were determined, which made it possible to obtain scaffolds with a given gradient porous structure. The solubility indices of the developed materials indicate the possibility of their use as medical devices.

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Section: Introductionsmentioning

confidence: 99%

Biocompatible Glass-Ceramic Scaffolds for Bone Endoprosthetics

Fesenko,

Babich,

Savvova

et al. 2022

InterConf+

Self Cite

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Study of mineralization of lithium calcium phosphosilicate glass ceramics in vivo during bone tissue regeneration

Savvova,

Fesenko,

Voronov

et al. 2023

Vopr. Khim. Khim. Tekhnol.

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Prospective directions for the creation of biologically active substitutes for bone tissue were analyzed. The effectiveness of the use of calcium phosphosilicate materials modified with CuO, ZnO, Ag2O, Fe2O3, TiO2, SrO and Nb2O5 to ensure high biocompatibility and antibacterial properties of bone endoprostheses has been established. The prospective use of lithium calcium phosphate silicate glass ceramics for obtaining strengthened, biologically active bone implants was substantiated. The main criteria for the development of biocompatible glass-ceramic materials regarding their composition, structure, texture, and surface properties have been established. The influence of differences in the structure and resorption of calcium phosphosilicate glass ceramics on the mechanism of formation of an apatite-like layer in vivo was analyzed. The features of mineralization of calcium phosphosilicate glass ceramics in vivo during bone tissue regeneration were determined, and the effectiveness of the use of glass ceramics based on hydroxyapatite and lithium disilicate in bone tissue replacement was established to reduce the rehabilitation period and long-term use of endoprostheses under variable loads. The developed OS-7 calcium phosphosilicate glass-ceramic material is characterized by the content of crystalline phases of 10 vol.% lithium disilicate and 55 vol.% hydroxyapatite with a ratio of CaO/P2O5=1.67, surface microrelief of 6 m, surface free energy value of 75 mJ/m2 and crack resistance of 6.0 MPam1/2. This material is biocompatible due to the formation of carbonate hydroxyapatite crystals already on the 14th day, which allows us to consider its promising use in the treatment of fractures, defects of long bones and in the replacement of short or tubular bones.

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Development of Strengthened Bioactive Calcium Phosphate-Silicate Glass Ceramics for Bone Implants

Cited by 2 publications

References 10 publications

Biocompatible Glass-Ceramic Scaffolds for Bone Endoprosthetics

Biocompatible Glass-Ceramic Scaffolds for Bone Endoprosthetics

Study of mineralization of lithium calcium phosphosilicate glass ceramics in vivo during bone tissue regeneration

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