Development of Sustained-Release Microbeads of Nifedipine and &lt;i&gt;In vitro&lt;/i&gt; Characterization

Bashir, Sajid; Asad, Muhammad Usman; Qamar, Shamsul; Karim, Sabiha

doi:10.4314/tjpr.v13i4.3

Cited by 9 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Korsmeyer‐Peppas model was identified as the best fit model for oxidized blend, suggesting that the release mechanism for OAX/CS blends was predominantly non‐Fickian diffusion. The diffusion exponent “n” for OAX/CS blends was determined to be greater than 0.5, supporting the non‐Fickian behavior, involving both diffusion and swelling control [61] . Of all the investigated oxidized blend compositions, the OAX/CS (1 : 2) blends emerged as highly effective excipients due to their notable diffusion exponent value of 0.845 (referenced in Table 4), indicative of anomalous transport.…”

Section: Resultsmentioning

confidence: 52%

“…The diffusion exponent "n" for OAX/CS blends was determined to be greater than 0.5, supporting the non-Fickian behavior, involving both diffusion and swelling control. [61] Of all the investigated oxidized blend compositions, the OAX/CS (1 : 2) blends emerged as highly effective excipients due to their notable diffusion exponent value of 0.845 (referenced in Table 4), indicative of anomalous transport. A release mechanism characterized by a diffusion exponent (n) value ranging between 0.45 and 0.89 (0.45 < n < 0.89) was termed "Anomalous (non-Fickian) transport."…”

Section: Kinetic Releasementioning

confidence: 98%

See 1 more Smart Citation

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Jabeen,

Iram,

Atif

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

This article presents the isolation of arabinoxylan (AX) from Plantago ovata seed husk and its oxidation using periodate to create oxidized‐AX (OAX) with distinct functionalities. Utilizing the solution casting method, biocompatible blends of arabinoxylan/chitosan (AX/CS) are prepared at various weight ratios, and their properties are assessed. Fourier transform infrared spectroscopy (FT‐IR), x‐ray diffraction (XRD), and thermogravimetric analysis (TGA) are employed to gauge compatibility and thermal traits of AX and OAX with CS. Solubility tests reveal partial and limited solubility of AX and OAX in distilled water, respectively. OAX displays favorable compressibility and flow rate through Carr's index, Hausner's ratio, and angle of repose analyses. FT‐IR data confirm intermolecular hydrogen bonding between CS′s −NH2− group and OAX′s carbonyl group, with XRD showing low crystallinity. Diclofenac sodium (DC) is loaded as a model drug into AX/CS and OAX/CS blends for release studies in pH 6.8 phosphate buffer. Results exhibit OAX/CS blends with sustained drug release, surpassing AX/CS blends. Among ratios tested, the OAX/CS (1 : 2) blend emerges as a superior excipient, demonstrating enhanced in‐vitro release potential, highlighting oxidized blends′ promise in sustained drug delivery systems.

show abstract

Section: Resultsmentioning

confidence: 52%

Section: Kinetic Releasementioning

confidence: 98%

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Jabeen,

Iram,

Atif

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Pellets are made by applying a film-forming polymer coating to inert medicament pellets. The polymer coating composition and coating quantity determine the release [10] .…”

Section: Pelletsmentioning

confidence: 99%

A review on micro beads: Formulation, technological aspects, and extraction

Shaik Khaja Moinuddin,

Pradeep Kumar M,

Sandeep Kumar G

et al. 2024

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

Any drug delivery system's purpose is to deliver a therapeutic amount of medicine to the appropriate place in the body while also achieving and maintaining the correct drug concentration. This could be accomplished by using numerous unit dosage forms such as microgranules/spheroids, pellets, microcapsules, and beads, which are divided into many separate units, referred to as subunits, each of which possesses certain desired features. The advantages of micro particle drug delivery systems over single unit dose form are well documented. One of the solutions that does not entail the use of harsh chemicals or elevated temperatures is the production of microbeads medication delivery systems. The traditional procedures require the use of ionotropic gelation methods, which include internal and external gelation methods, emulsion gelation methods, polyelectrolyte complexation methods, and so on. Because of the ease of preparation, the majority of work has been done on the preparation of microbeads using the ionotropic gelation process rather than alternative approaches.

show abstract

“…Prior to consideration, the small amount of microbeads was spread on adhesive tape after that adhesive tape implied on gold coated aluminum stub. A Scanning electron photomicrograph was taken at an acceleration voltage of 20KV [13,14]. Entrapment Efficiency Amount of microbeads were taken that contained 10 mg of drug then suspended in 10 ml of methanol.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Development of gastro retentive microbeads for sustained release of fexofenadine and montelukast

Haleem

Khan

Syed³

et al. 2021

JCP

View full text Add to dashboard Cite

In allergic rhinitis, montelukast (leukotriene receptor antagonist) in combination with fexofenadine (antihistamine) provide improved and complimentary effects and reduce the allergic symptoms effectively. Montelukast has less bioavailability due to hepatic first pass metabolism and fexofenadine have low permeability. So sustained release delivery is crucial for these drugs. One of the techniques to overcome this challenge is the development of polymeric microspheres or microbeads for enhanced bioavailability and prolong the action of drug in body. The objective of the study is to produce a potential microencapsulated formulation having the combination of fexofenadine hydrochloride and montelukast sodium. Microbeads were formulated by using polymer, eudragit RS100. Single emulsion solvent evaporation method was used for the preparation of formulation. The developed drug loaded polymeric microbeads showed that percentage floating ranged from 82.1 - 90.4%. Entrapment efficiency of microbeads were found between 68.8- 80.9%. FTIR results revealed absence of drug-polymer interaction. In-vitro release studies shown that from all the prepared formulations of both drugs the optimum formulation was released up to 24hrs and percentage cumulative drug release was 87.40% and 89.78% respectively. The acute toxicity study showed the safety of the developed system. Formulated microbeads were significantly efficient to achieve a sustained release of fexofenadine and montelukast with prolonged therapeutics release up to 24 hours. The developed gastro retentive floating drug delivery systems showed excellent physicochemical properties and sustained drug release pattern, thereby improving the bioavailability of the drugs.

show abstract

Development of Sustained-Release Microbeads of Nifedipine and <i>In vitro</i> Characterization

Cited by 9 publications

References 12 publications

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

A review on micro beads: Formulation, technological aspects, and extraction

Development of gastro retentive microbeads for sustained release of fexofenadine and montelukast

Contact Info

Product

Resources

About