The minimum wall thickness required to prevent seismic buckling of a reactor vessel (RV) in a fast reactor is derived using the system based code (SBC) concept. One of the key features of SBC concept is margin optimization; to implement this concept, the reliability design method is employed, and the target reliability for seismic buckling of the RV is derived from nuclear plant safety goals. Input data for reliability evaluation, such as distribution type, mean value, and standard deviation of random variables, are also prepared. Seismic hazard is considered to evaluate uncertainty of seismic load. Minimum wall thickness required to achieve the target reliability is evaluated, and is found to be less than that determined from a conventional deterministic design method. Furthermore, the influence of each random variable on the evaluation is investigated, and it is found that the seismic load has a significant impact.