Development of the caruncular and intercaruncular regions in the bovine endometrium

Atkinson, B. A.; King, G. J.; Amoroso, E. C.

doi:10.1095/biolreprod30.3.763

Cited by 69 publications

(32 citation statements)

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“…Caruncular arrangement in S. caffer in two mesometrial and two antimesometrial rows along most parts of the uterine horns and orientation of ovoid caruncles of the non-pregnant uterus in parallel to the longitudinal axis of the uterine horns are in accordance with descriptions in B. taurus [9] and [16] and B. bubalis [17]. In contrast, in the pregnant S. caffer uterus, ovoid placentomes are orientated perpendicular to the longitudinal axis of the horns, characteristic of a polycotyledonary type placenta [9].…”

Section: Discussionsupporting

confidence: 82%

Histo-morphology of the Uterus and Early Placenta of the African Buffalo (Syncerus caffer) and Comparative Placentome Morphology of the African Buffalo and Cattle (Bos taurus)

et al. 2006

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Differences exist in reproductive physiology between African buffalo (Syncerus caffer), cattle (Bos taurus) and water buffalo (Bubalus bubalis). The aim of this study was to histo-morphologically compare the anatomy of non-pregnant and pregnant uteri of buffalo and cattle. Two non-pregnant uteri and placentae of six pregnant African buffalo were used. Early placentome formation (fetal crown rump length (CRL): 2-17.5 cm) in S. caffer and B. taurus was compared. The endometrium of buffalo uteri comprises round to ovoid, dome-shaped and gland-free caruncles. A predominantly simple columnar epithelium of non-ciliated cells covers caruncular tissue, while, additionally, ciliated cells occur in the epithelium of the intercaruncular areas and within the simple columnar or pseudostratified epithelium of the endometrial glands. During early gestation, multiple placentomes develop. Unlike the placentomes in cattle at similar CRL, buffalo placentomes do not develop a caruncular stalk. The sessile, dome-shaped buffalo placentome has simple, slightly conical villi branching less than in cattle, thus indicating different and less complex feto-maternal interdigitation than seen in the latter. A synepitheliochorial interhaemal barrier can be expected in the buffalo placenta, as the occurrence and ultrastructure of trophoblast giant cells resemble those described in cattle.

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Section: Discussionsupporting

confidence: 82%

Histo-morphology of the Uterus and Early Placenta of the African Buffalo (Syncerus caffer) and Comparative Placentome Morphology of the African Buffalo and Cattle (Bos taurus)

et al. 2006

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“…After embryo implantation, the caruncles grow rapidly and form individual placentomes, which are responsible for gaseous and small molecule exchange. Because the uterine glands play an important role in the supply of large molecules to the embryo before and after implantation (Atkinson et al 1984), the intercaruncular tissue samples were preferred for gene expression analyses.…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle

Mitko¹,

Ulbrich²,

Wenigerkind³

et al. 2008

Reproduction

115

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During the oestrous cycle, the bovine endometrium exhibits characteristic morphological and functional changes, which are mainly induced by progesterone (P 4 ), oestrogens and oxytocin. We studied the response of the endometrium to this changing hormonal environment at the transcriptome level using a custom-made cDNA microarray. Endometrium samples were recovered from Simmental heifers on days 0 (oestrus), 3.5 (metoestrus), 12 (dioestrus) and 18. The latter group was divided into animals with high (late dioestrus) and low P 4 levels (preoestrus). Significance analysis of microarrays revealed 269 genes exhibiting significant changes in their transcript levels during the oestrous cycle in distinct temporal patterns. Two major types of expression profiles were observed, which showed the highest mRNA levels during the oestrus phase or the highest levels during the luteal phase respectively. A minor group of genes exhibited the highest mRNA levels on day 3.5. Gene ontology (GO) analyses revealed GO categories related to extracellular matrix remodelling, transport, and cell growth and morphogenesis enriched at oestrus, whereas immune response and particular metabolic pathways were overrepresented at dioestrus.

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“…endometrium, i.e., in the caruncle (CAR) but not in the intercaruncle (ICAR) [9,10]. The placentomes contain fetal and maternal information because they are the interface of two tissue sources, i.e., the maternal endometrium and the fetal trophoblasts.…”

mentioning

confidence: 99%

Analysis of Uteroplacental-specific Molecules and Their Functions During Implantation and Placentation in the Bovine

Hashizume

2007

Journal of Reproduction and Development

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Abstract. In cattle, the mechanisms underlying implantation and placental development are still unclear. Synepitheliochorial placentation in cattle is noninvasive, and thus generates limited interest in terms of degradation and remodeling of endometrial tissues. The overall purpose of this study was three-fold: (1) to examine the gene circuitry around the implantation window, (2) to understand development of the placenta during the peri-implantation period by using a uteroplacental cDNA microarray, and (3) to study the roles of molecules involved in endometrial remodeling. Bovine trophoblastic binucleate cell-specific molecules, such as pregnancy-associated glycoproteins (PAGs), placental lactogen (PL), and prolactin-related proteins (PRPs), were markedly expressed in binucleate cells (BNCs) around implantation. The expression of PRP-1 was specific to the caruncular (CAR) area of the gravid uterine horn. Gelatinases (MMP-2 and -9) in association with heparanase may be central to endometrial remodeling. In situ hybridization analyses of PAGs, PRPs, PL, and heparanase suggested that BNCs expressed these molecules simultaneously. Future studies will further investigate the specific roles of these molecules in placentogenesis. The uteroplacental cDNA microarray presented cascades of molecular signatures not only for the endometrium but also for the intricate dialogue at the level of the feto-maternal interface in cattle. Placentome morphogenesis potentially parallels the dynamic multigenic circuitry and regulates the cell cycle in the endometrium. The roles of BNCs and their secreted molecules remain an enigma, particularly with regard to the adhesion process and endometrial remodeling, which is the focus of this study.

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Development of the caruncular and intercaruncular regions in the bovine endometrium

Cited by 69 publications

References 0 publications

Histo-morphology of the Uterus and Early Placenta of the African Buffalo (Syncerus caffer) and Comparative Placentome Morphology of the African Buffalo and Cattle (Bos taurus)

Histo-morphology of the Uterus and Early Placenta of the African Buffalo (Syncerus caffer) and Comparative Placentome Morphology of the African Buffalo and Cattle (Bos taurus)

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle

Analysis of Uteroplacental-specific Molecules and Their Functions During Implantation and Placentation in the Bovine

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