The first kidney transplant on the African continent was performed in Johannesburg, South Africa (SA), by Thomas Starzl and Bert Myburgh in 1966, [1] preceding the world's first heart transplant performed by Christiaan Barnard in Cape Town in 1967. [2] Transplant activity in SA remains lower than that achieved by other countries with comparable economic capacity. [3] Currently there are seven centres each in the public and private sectors offering kidney transplantation, distributed between five cities and four provinces. These transplant centres serve the 30 dialysis units in the public sector and the 228 units in the private sector. [4] Kidney disease is increasing in SA and has become one of the leading causes of mortality, accounting for a staggering 1 000 deaths per million population (pmp). [5] The challenge of coping with this situation is starkly illustrated in a recent report from a renal unit in Western Cape Province that currently accepts only 25% of patients with endstage kidney disease (ESKD) referred for treatment, down from 50% a decade ago. [6,7] The growing demand for renal replacement treatment places enormous pressure on already overburdened dialysis units around the country; the units in the public sector are particularly stressed. [8,9] SA has a two-tiered health system: a private health system is available to the 16% of the population that is able to afford medical insurance, and benefits from world-class medical care, while the remaining majority (84%) of uninsured individuals are served by state facilities that are generally under-staffed and under-resourced. [10] The marked discrepancy in healthcare is poignantly reflected in the access to renal replacement treatment: in 2015 the treatment rate in the public sector was 72 pmp compared with 799 pmp in the private sector. [4] The higher treatment rate in the private sector is because dialysis is a 'prescribed minimum benefit' introduced in SA in 1998 and requiring health insurers, among other obligations, to guarantee treatment for 25 chronic diseases, including chronic renal failure, regardless of the benefit option selected by the patient. To cope with the demand for renal replacement treatment, the number of private dialysis units increased dramatically from 5 in 1994 to 228 in 2015; during the same period, the number of units in the public sector merely increased from 26 to 30. [4] Haemodialysis was the predominant form of renal replacement in both sectors, with 46% of patients in the public sector and 85% in the private sector receiving this treatment. Only 25% of renal replacement patients in the public sector and a mere 8% in the private sector were kidney transplant recipients. [4] Objectives With kidney transplantation recognised as the most effective treatment for ESKD, both clinically and economically, the author interrogated the pattern of kidney transplantation in SA in the hope of assisting clinicians and health authorities in both the public and private sectors to develop strategies to improve kidney transplantation rates in ...