Development of the Entorhino‐Hippocampal Projection: Guidance by Cajal‐Retzius Cell Axons

Ceranik, Katja; Zhao, Shanting; Frotscher, Michael

doi:10.1111/j.1749-6632.2000.tb06718.x

Cited by 27 publications

(22 citation statements)

References 40 publications

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“…Hippocampal CR cells and Reelin are essential for the establishment of the entorhinal-hippocampal pathways (Del Rio et al, 1997;Super et al, 1998;Ceranik et al, 2000), and the connectivity of the p73 Ϫ/Ϫ hippocampus is probably profoundly disturbed. We show that CR cells may also be critical for the folding of the hippocampal fissure.…”

Section: The P73mentioning

confidence: 99%

Developmental Roles of p73 in Cajal-Retzius Cells and Cortical Patterning

Meyer¹,

Socorro²,

Garcia³

et al. 2004

J. Neurosci.

122

129

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To examine the role of the p53 homolog p73 in brain development, we studied p73 Ϫ/Ϫ , p73 ϩ/Ϫ , E2F1 Ϫ/Ϫ , and reeler mutant mice. p73 in developing brain is expressed in Cajal-Retzius (CR) cells, the cortical hem, and the choroid plexus. p73-expressing CR cells are lost in p73 Ϫ/Ϫ embryos, although Reelin is faintly expressed in the marginal zone. Ectopic neurons in the p73 Ϫ/Ϫ preplate and cortical hem at embryonic day 12 implicate p73 in the early developmental program of the cortex; however, preplate partition and early cortical plate formation are not disturbed. Postnatal p73 Ϫ/Ϫ mice show a mild hypoplasia of the rostral cortex and a severely disrupted architecture of the posterior telencephalon. In the developing p73 Ϫ/Ϫ hippocampus, the most striking abnormality is the absence of the hippocampal fissure, suggesting a role of p73 in cortical folding. p73 ϩ/Ϫ mice have a less severe cortical phenotype; they display a dorsal shift of the entorhinal cortex and a reduced size of occipital and posterior temporal areas, which acquire entorhinal-like features such as Reelinpositive cells in layer II. CR cells appear unaffected by heterozygosity. We relate the malformations of the posterior pole in p73 mutant mice to alterations of p73 expression in the cortical hem and suggest that p73 forms part of an early signaling network that controls neocortical and archicortical regionalization. In mice deficient for the transcription factor E2F1, a main activator of the TAp73 (transactivating p73) isoform, we find a defect of the caudal cortical architecture resembling the p73 ϩ/Ϫ phenotype along with reduced TAp73 protein levels and propose that an E2F1-TAp73 dependent pathway is involved in cortical patterning.

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Section: The P73mentioning

confidence: 99%

Developmental Roles of p73 in Cajal-Retzius Cells and Cortical Patterning

Meyer¹,

Socorro²,

Garcia³

et al. 2004

J. Neurosci.

122

129

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“…Cajal‐Retzius (CR) cell is believed as a pioneer neuron for the guidance of fiber's ingrowth. The guidance function of CR cell was also studied in the pathfinding of perforant pathway (Ceranik et al, 1999, 2000; Zhao et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The tracing study of developing entorhino‐hippocampal pathway

Deng

et al. 2007

Intl J of Devlp Neuroscience

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The entorhino-hippocampal pathway is the major excitatory input from neurons of the entorhinal cortex on both ipsilateral and contralateral hippocampus/dentate gyrus. This fiber tract consists of the alvear path, the perforant path and a crossed commissural projection. In this study, the histogenesis and development of the various subsets of the entorhino-hippocampal projection have been investigated. DiI, DiO, Fast Blue tracing and calretinin immunocytochemistry as well as were carried out with pre and postnatal rats at different developmental stages. The alvear path and the commissural pathway start to develop as early as embryonic day E16, while the first perforant afferents reach the stratum lacunosum-moleculare of the hippocampus at E17 and at outer molecular layer of the denate gyrus at postnatal day 2. Retrograde tracing with DiI identifies entorhinal neurons in layer II-IV as the developmental origin of the entorhino-hippocampal pathway. Furthermore, calretinin immunocytochemistry revealed transitory Cajal-Retzius cells in the stratum lacunosum-moleculare of the hippocampus from E16. DiI labeling of entorhinal cortex fibers and combined calretinin-immunocytochemistry reveal a close relationship between Cajal-Retzius cells and entorhinal afferents. This temporal and spatial relationship suggests that Cajal-Retzius cell serves as a guiding cue for entorhinal afferents at early cortical development.

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“…These cells are transiently present within the outer molecular layer and function as pioneer neurons during development (del Rio et al, 1997;Super et al, 1998b;Ceranik et al, 1999Ceranik et al, , 2000. Experimental removal of Cajal-Retzius cells during a critical developmental time period prevents the layer-specific ingrowth of entorhinal fibers, which indicates that these cells are essential for the formation of a normal entorhinodentate pathway.…”

Section: Entorhinal Afferents Terminate Normally In Beta2/neurod-/-micementioning

confidence: 98%

“…During development, Cajal-Retzius cells act as pioneer neurons for the entorhinodentate fibers (del Rio et al, 1997;Super et al, 1998a;Ceranik et al, 2000). Although the majority of these cells die postnatally, a small number survives even in the adult.…”

Section: Cajal-retzius Cells In the Termination Zone Of Entorhinal Afmentioning

confidence: 99%

Laminar organization of the mouse dentate gyrus: Insights from BETA2/Neuro D mutant mice

Turco

Gebhardt

Burbach

et al. 2004

J of Comparative Neurology

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The dentate gyrus of rodents is characterized by a highly laminar organization: above a compact granule cell layer, commissural/associational (C/A) fibers terminate on proximal granule cell dendrites and entorhinal fibers terminate on distal granule cell dendrites in a nonoverlapping manner. To gain insights into mechanisms that underlie the formation of this laminar structure, we studied mice deficient for BETA2/NeuroD, a basic helix-loop-helix transcription factor essential for granule cell differentiation. Anterograde tracing was used to label C/A and entorhinal fibers and combined with confocal double immunofluorescence for calbindin, calretinin, parvalbumin, and reelin to visualize putative target cells. The dentate gyrus of mutant mice contained only few granule cells, which formed a cap-like structure adjacent to area CA3. Despite the severe hypoplasia of the dentate gyrus, the remaining BETA2/NeuroD-deficient granule cells expressed mature markers, extended dendrites into the molecular layer, and extended mossy fibers into area CA3. Entorhinal and C/A fibers terminated in a nonoverlapping manner in the dendritic field overlying the rudiment. Entorhinal fibers terminated in the outermost portion of the dentate gyrus where they surrounded reelin-positive Cajal-Retzius cells, and C/A fibers terminated above and within the dentate rudiment. The laminar termination of C/A fibers was closest to normal in zones of the rudiment in which granule cells were densely packed. These data indicate that granule cells are able to differentiate in the absence of BETA2/NeuroD and suggest that the signals underlying the laminar anatomy of the dentate gyrus are present in the absence of most target cells.

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Development of the Entorhino‐Hippocampal Projection: Guidance by Cajal‐Retzius Cell Axons

Cited by 27 publications

References 40 publications

Developmental Roles of p73 in Cajal-Retzius Cells and Cortical Patterning

Developmental Roles of p73 in Cajal-Retzius Cells and Cortical Patterning

The tracing study of developing entorhino‐hippocampal pathway

Laminar organization of the mouse dentate gyrus: Insights from BETA2/Neuro D mutant mice

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