Development of the human pancreas and its vasculature — An integrated review covering anatomical, embryological, histological, and molecular aspects

Henry, Brandon Michael; Skinningsrud, Bendik; Saganiak, Karolina; Pękala, Przemysław A.; Walocha, Jerzy; Tomaszewski, Krzysztof A.

doi:10.1016/j.aanat.2018.09.008

Cited by 44 publications

(31 citation statements)

References 71 publications

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“…The pancreas develops as an endodermal outgrowth from two pancreatic buds which develop at the junction of the foregut and midgut around the second and third weeks of intrauterine life ( Figure 1) [11]. The smaller ventral bud has two lobes, right and left, of which the left lobe regresses, while the right lobe persists as the ventral bud which grows into the ventral mesentery [12].…”

Section: Review Anatomy and Embryology Of The Pancreatic Ductsmentioning

confidence: 99%

“…The smaller ventral bud has two lobes, right and left, of which the left lobe regresses, while the right lobe persists as the ventral bud which grows into the ventral mesentery [12]. The larger dorsal bud grows posteriorly into the dorsal mesentery [11]. The rotation of the foregut (stomach and duodenum) ensures the duodenum becomes a retroperitoneal structure, carrying with it the developing pancreas.…”

Section: Review Anatomy and Embryology Of The Pancreatic Ductsmentioning

confidence: 99%

“…Anatomically, the pancreas is a retroperitoneal organ made up of exocrine and endocrine secretory components. It has a head which lies in the concavity of the duodenum, a neck which lies anterior to the commencement of the portal vein, a body which extends to the hilum of the left kidney, and a tail which lies in the splenorenal ligament, extending to the splenic hilum [11]. The main pancreatic duct extends from the tail to the head of the gland, draining most of the gland and joining the bile duct at the hepatopancreatic ampulla to drain into the second part of the duodenum.…”

Section: Figure 1: Development Of the Pancreasmentioning

confidence: 99%

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Pancreatic Duct Variations and the Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Ojo

2020

Cureus

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Endoscopic retrograde cholangiopancreatography (ERCP) is an important diagnostic and therapeutic procedure in the management of biliary and pancreatic disorders. Despite advances in ERCP facilities and techniques, pancreatitis remains the most common and feared complication of this procedure. The technical challenges of ERCP could be further compounded by variations in the configuration of the pancreatic ductal system. As a result, the knowledge of these variations and their potential role in the development of post-ERCP pancreatitis (PEP) is essential to any successful risk reduction strategy. This review provides an overview of the anatomy and embryological basis of pancreatic duct variations, as well as explore the different types and prevalence of these variations. Also, we discuss the mechanisms of PEP and provide evidence supporting a link between the variations and PEP using published data

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Section: Review Anatomy and Embryology Of The Pancreatic Ductsmentioning

confidence: 99%

Section: Review Anatomy and Embryology Of The Pancreatic Ductsmentioning

confidence: 99%

Section: Figure 1: Development Of the Pancreasmentioning

confidence: 99%

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Pancreatic Duct Variations and the Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Ojo

2020

Cureus

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“…As a result, the pancreas is made up of two parts with different cells and functions: an endocrine and an exocrine part. The endocrine component is known for its hormone secretion such as insulin, glucagon, somatostatin, and pancreatic polypeptide and its role in blood sugar‐regulating and the exocrine component has an essential part in the digestion of fats, carbohydrates, and proteins in the duodenum . These data show that any disturbance in this organ would disarrange the function of the digestive and endocrine system and would put the patient's body in a lot of problems.…”

Section: Introductionmentioning

confidence: 99%

“…The pancreas is one of the most critical components of the body that is located behind the stomach in the abdomen and is divided into a head, neck, body, and tail. 1 The importance of this organ is because of its twofold function in the endocrine and digestive system. As a result, the pancreas is made up of two parts with different cells and functions: an endocrine and an exocrine part.…”

Section: Introductionmentioning

confidence: 99%

The potential role of chitosan‐based nanoparticles as drug delivery systems in pancreatic cancer

2020

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Pancreatic cancer (PC) is one of the most lethal cancers and 12th most common cancer in the world. Due to the inaccessible anatomical position of the pancreas and asymptomatic early stages of this disease, PC has a high mortality rate. Therefore, providing reliable diagnostic and therapeutic tools are the keys to increase the PC survival rate. Nanotechnology is an inchoate field of science that previously scientists' tendency to enhance the efficacy of current preventive, diagnostic, and therapeutic methods has oriented them to build a bridge between this science and medicine. In the case of PC, nanotechnology suggests using drug delivery devices for a more effective and targeted therapy. Chitosan is a natural polymer that recently has attracted a lot of attention for being renewable, nontoxic, and bioabsorbable. In this article, we tend to look for the answer to this question: has nanotechnology been successful in using chitosan‐based nanoformulations as carriers for preventing more individuals from suffering or at least increasing the 5‐year survival of the PC patients?

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Next‐Generation Sequencing: An Advanced Diagnostic Tool for Detection of Pancreatic Disease/Disorder

Biswas,

Afrose,

Mita

et al. 2024

JGH Open

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The pancreas is involved in digestion and glucose regulation in the human body. Given the recognized link between chronic pancreatitis and pancreatic cancer, addressing pancreatic disorders and pancreatic cancer is particularly challenging. This review aims to highlight the limitations of traditional methods in diagnosing pancreatic disorders and cancer and explore several next‐generation sequencing (NGS) approaches as a promising alternative. There are distinct clinical symptoms that are shared by a number of clinical phenotypes of pancreatic illness induced by particular genetic mutations. Traditional diagnostic methods encompass computed tomography, magnetic resonance imaging, contrast‐enhanced Doppler ultrasound, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, transabdominal ultrasound, laparoscopy, and positron emission tomography have a prognostic ability of only 5% or less and a 5‐year survival rate. Genetic sequencing can be employed as an alternative to conventional diagnostic techniques. Sanger sequencing and NGS are currently largely operated genome analysis, with no exception for pancreatic disease diagnosis. The NGS methods can sequence millions to billions of short DNA fragments, enabling enormous sample screening in a short amount of time with low‐abundance detection, like in 0.1%–1% mutation prevalence declining approximate cost. Whole‐genome sequencing, whole‐exome sequencing, RNA sequencing, and single‐cell NGS are a few NGS methods utilized to diagnose pancreatic disease. For both research and clinical applications, the NGS techniques can provide a precise diagnosis of pancreatic disorders in a short amount of time at a reasonable expenditure.

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Development of the human pancreas and its vasculature — An integrated review covering anatomical, embryological, histological, and molecular aspects

Cited by 44 publications

References 71 publications

Pancreatic Duct Variations and the Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Pancreatic Duct Variations and the Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

The potential role of chitosan‐based nanoparticles as drug delivery systems in pancreatic cancer

Next‐Generation Sequencing: An Advanced Diagnostic Tool for Detection of Pancreatic Disease/Disorder

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