Development of the mussel-inspired pH-responsive hydrogel based on Bletilla striata polysaccharide with enhanced adhesiveness and antioxidant properties

Ma, Zihao; Yang, Xiao Feng; Ma, Jie; Lv, Jinying; He, Jianyong; Jia, Duowuni; Qu, Yan; Chen, Gongzheng; Yan, Heng-Xiu; Zeng, Rui

doi:10.1016/j.colsurfb.2021.112066

Cited by 39 publications

(16 citation statements)

References 43 publications

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“…This hydrogel exhibited a magnetic response that could potentially prevent breast cancer recurrence. Likewise, pH-responsive carboxymethylated Bletilla striata polysaccharide (CBSP)- graft -dopamine (DA) hydrogel was reported where an amide bond was formed between −COOH of CBSP and primary −NH 2 group in DA . Moreover, a cytocompatible hydrogel was produced by cross-linking the DCBSP conjugate with an efficacious cross-linker, in which an active catechol group of DA lost two protons and two electrons to give an agile quinone.…”

Section: Hydrogel Cross-linking Methodsmentioning

confidence: 99%

“…Likewise, pH-responsive carboxymethylated Bletilla striata polysaccharide (CBSP)-graft-dopamine (DA) hydrogel was reported where an amide bond was formed between −COOH of CBSP and primary −NH 2 group in DA. 115 Moreover, a cytocompatible hydrogel was produced by cross-linking the DCBSP conjugate with an efficacious crosslinker, in which an active catechol group of DA lost two protons and two electrons to give an agile quinone. Simultaneously, Forouzandehdel et al reported magnetic composite polysaccharide-based hydrogel by grafting itaconic acid onto alginic acid and starch in the presence of Fe 3 O 4 nanoparticles and graphene sheets for the purpose of targeted drug delivery.…”

Section: Small Molecules As Linkersmentioning

confidence: 99%

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Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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Hydrogels are a soft material that undergoes cross-linking between polymers to form a hydrophilic three-dimensional network. In fact, similarity to body tissue, soft consistency, biocompatibility, and elasticity, impart a protagonic role of hydrogel to be applied as a biomaterial. In response to external cues, stimuli-responsive hydrogels are particularly impactful, enabling remarkable levels of control over material properties. They can endure changes in swelling behavior, permeability, network structure, and mechanical strength. Nevertheless, such changes induce single-cycle or reversible transitions, so hydrogels can regain their initial state once the trigger is removed. Recently, polysaccharide-based hydrogels with stimuli-responsive properties resulted in developing biomimetic structures for a widespread biotechnological application owing to their excellent biodegradability, biocompatibility, nonimmunogenicity, functional properties, ease of gelation, and derivatization. This review will initially highlight recent advances in cross-linking methods and chemistry for preparing stimuli-responsive hydrogels. Subsequently, state-of-the-art techniques to understand the structural, chemical, and rheological behavior of polysaccharide-based stimuli-responsive hydrogel will be discussed. Additionally, the responsiveness of polysaccharide hydrogel toward diverse stimuli such as redox, temperature, light, pH, magnetism, electricity, etc., with a broad spectrum of applications will be described in detail. This review also attempts to address the lacunae of existing stimuli-responsive hydrogel and their future perspectives.

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Section: Hydrogel Cross-linking Methodsmentioning

confidence: 99%

Section: Small Molecules As Linkersmentioning

confidence: 99%

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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“…The wide peaks appeared at 20.06°of GG, DP, GDP-1, and GDPP-1, which proved that they were amorphous substances. 37 Hence, the addition of PVA and phytol did not lead to a change in the crystal structure of the hydrogel, and the hydrogel could maintain its own interpenetrating network structure.…”

Section: Characterization and Water−holding Capacitymentioning

confidence: 97%

High-Release, Residue-Free Polysaccharide Hydrogel for Refrigerated Food Preservation

Cui

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Hundreds of millions of tons of food resources are wasted annually due to microbial contamination. Effective food packaging can prevent food contamination and wastage. However, traditional food packaging has the problem of low release of bioactive substances. This study aimed to prepare a pH-responsive polysaccharide hydrogel (GDPP) by double cross-linking of ester and hydrogen bonds that could result in a high release of bioactive substances and no residual peeling. The infrared results showed the existence of ester bonds in the hydrogel, and the scanning electron microscopy results showed the porous network structure of the hydrogel. The results of texture profile analysis and self-healing tests showed that GDPP-1 has good mechanical and self-healing properties. Moreover, the ester bond of the hydrogel broke in response to the pH in the environment, improving the swelling and release properties of the hydrogel. The equilibrium swelling ratio of GDPP-1 was greater than 1000%, and the release rate of bioactive substances was more than 80%. Notably, the results of peeling experiments showed that only 0.1 N external force was needed to separate the hydrogel from the salmon, and no residue was observed on the salmon surface. The final freshness test results showed that the hydrogel effectively prolonged the shelf life of refrigerated salmon for 3–6 days. These findings indicated that hydrogels could be used in food packaging to extend the shelf life of refrigerated food. Furthermore, their advantages of low cost and simple preparation can better meet the needs of food industry applications.

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“…After carboxymethylation, Bletilla striata polysaccharides can form a multifunctional hydrogel with the dopamine conjugate catechol group, and its antioxidant properties and tissue adhesion are greatly improved. The encapsulated berberine exerts excellent and long-lasting antibacterial activity [ 152 ]. Oxidative stress in the brain leads to neuronal damage and necrosis, and antioxidants help reduce oxidative stress.…”

Section: Biomedical and Medicinal Application Of Natural Polysaccharidesmentioning

confidence: 99%

Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications

Bai

Zhou

et al. 2022

Antioxidants

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Many chronic diseases such as Alzheimer’s disease, diabetes, and cardiovascular diseases are closely related to in vivo oxidative stress caused by excessive reactive oxygen species (ROS). Natural polysaccharides, as a kind of biomacromolecule with good biocompatibility, have been widely used in biomedical and medicinal applications due to their superior antioxidant properties. In this review, scientometric analysis of the highly cited papers in the Web of Science (WOS) database finds that antioxidant activity is the most widely studied and popular among pharmacological effects of natural polysaccharides. The antioxidant mechanisms of natural polysaccharides mainly contain the regulation of signal transduction pathways, the activation of enzymes, and the scavenging of free radicals. We continuously discuss the antioxidant activities of natural polysaccharides and their derivatives. At the same time, we summarize their applications in the field of pharmaceutics/drug delivery, tissue engineering, and antimicrobial food additives/packaging materials. Overall, this review provides up-to-date information for the further development and application of natural polysaccharides with antioxidant activities.

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Development of the mussel-inspired pH-responsive hydrogel based on Bletilla striata polysaccharide with enhanced adhesiveness and antioxidant properties

Cited by 39 publications

References 43 publications

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

High-Release, Residue-Free Polysaccharide Hydrogel for Refrigerated Food Preservation

Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications

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