Development of tissue adhesion method using integrated low-level energies

Katoh, Ayako; Masuzawa, Toru; Ozeki, Kazuhide; Kishida, Akio; Kimura, Tsuyoshi; Higami, Tetsuya

doi:10.1016/j.medengphy.2009.12.005

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…The mechanism is an incision by mechanical vibration of the blade and coagulation of the proteins in tissue by the frictional heat that occurs between the tissues due to the ultrasonic vibration of the blade [9,11]. Several researchers have developed such ultrasonic adhesive devices [12], which can cut and close blood vessels safely. We tried to develop this type of versatile tissue-bonding technology in a former study.…”

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confidence: 99%

Synthetic polymer–tissue adhesion using an ultrasonic scalpel

et al. 2010

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Synthetic polymer–tissue adhesion using an ultrasonic scalpel

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“…The pressure pressed the two different materials together and the heat evaporated water from the interface. The heat and vibration were transmitted by pressing the polymer and the tissue together, which also caused the polymer chains to chemically interact with the proteins in the tissue, resulting in the formation of a crosslink (Figure ) . When the plain PE and PS films were used for the adhesion test, none adhered to the tissue.…”

Section: Discussionmentioning

confidence: 99%

“…We focused on achieving adhesion between an implant and a native tissue by means of an ultrasonically activated scalpel that applies heat and pressure to both components . This technique, which was originally developed to stop bleeding by coagulating the proteins in the tissue, is very effective for the adhesion of materials such as polymers and metals to tissue because the heat and pressure applied to the materials and the tissue enables bonding by a mechanism similar to that of protein coagulation as mentioned above . We found that this principle could be used to develop a new device for achieving adhesion between materials and tissue .…”

Section: Introductionmentioning

confidence: 99%

“…These findings were based on the structural and physical properties of the material, which had bonded to tissue upon the application of heat and mechanical vibration generated by the blade of an ultrasonically activated scalpel . Pressurization of the tissue and polymer brought them together, and evaporation of the water by the heat promoted thermal cross‐linking between the polymer and the proteins in the extracellular matrix, especially the collagens . Polymers have nothing in common, including in their surface properties, beyond the presence of carboxyl or hydroxyl groups.…”

Section: Introductionmentioning

confidence: 99%

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Adhesion between polymer surface modified by graft polymerization and tissue during surgery using an ultrasonically activated scalpel device

Nam

Iwata

Kimura

et al. 2014

J of Applied Polymer Sci

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In the field of surgery, achieving adhesion between a polymer implant and tissue poses a challenge considering that suturing is not appropriate for the stability of such implants. An ultrasonically activated scalpel that generates heat by mechanical vibration and promotes adhesion between a polymer implant and native tissue by pressing the two materials together has very good potential for application in the field. To determine the type of polymer that is suitable for the purpose, we investigated polyethylene (PE) and polystyrene (PS) films, the surfaces of which were activated by corona discharge. Graft polymerization was then performed on the corona‐treated surfaces to vary their properties. The corona‐treated PE and PS films grafted with poly(acrylic acid), poly(methacrylic acid), poly(vinyl benzylacrylic acid), and poly(hydroxylethyl acrylate), respectively, adhered to the tissue when the ultrasonically activated scalpel was applied. The heat generated by the mechanical vibration and the applied pressure enabled the carboxyl or hydroxyl groups to bond with the proteins in the extracellular matrix. We therefore concluded that it was possible to integrate this technique in the development of new types of polymer devices that could be stably implanted in a living body. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40885.

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“…The dissipative heat that is produced by the vibration is directly transferred to the target polymer or tissue along with the vibration. Using this clamp, it is possible to apply heat and vibration to a target biomedical polymer or tissue where the heat disentangles the collagen fibers as the vibration stimulates the collagen fibers to aggregate …”

Section: Introductionmentioning

confidence: 99%

Fundamental study on the development of a surgical device for polymer‐tissue adhesion using vibration damping of polymeric materials

Nam

Yamamoto

Kasahara

et al. 2013

J of Applied Polymer Sci

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To develop a surgical handheld device that can be used to promote polymer-tissue or tissue-tissue adhesion, we designed a polymeric clamp material (PCM) that self-heats as a result of vibration. By using the PCM, heat can be applied to the target biomaterial and the tissue simultaneously. The optimal temperature is high enough to promote adhesion but low enough to retain the native tissue's integrity. Furthermore, the PCM should not adhere to the target polymer or the native tissue. We found that the temperatures of fluorinated polymers, such as poly(tetrafluoroethylene) (PTFE) and perfluoroalkoxy (PFA), increased within 60 s to 150 C and maintained a stable temperature thereafter. The heat that was transferred to the saucer attached to the potential PCM was slightly above 100 C, a temperature that promotes adhesion but does not damage the native tissue. No deformation or melting was observed during the experiment, indicating that PTFE or PFA possess desirable PCM characteristics for use as a surgical heating device.

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Development of tissue adhesion method using integrated low-level energies

Cited by 7 publications

References 7 publications

Synthetic polymer–tissue adhesion using an ultrasonic scalpel

Synthetic polymer–tissue adhesion using an ultrasonic scalpel

Adhesion between polymer surface modified by graft polymerization and tissue during surgery using an ultrasonically activated scalpel device

Fundamental study on the development of a surgical device for polymer‐tissue adhesion using vibration damping of polymeric materials

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