Development of tissue-equivalent phantoms for biomedical ultrasonic applications

Singh, Manju; Singh, Harish K.; Kumar, Ashvani; Singh, V.R.; Pant, Kiran; Sethi, Poonam

doi:10.1504/ijbet.2008.016961

Cited by 5 publications

(3 citation statements)

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“…Agar-based tissue-mimicking materials are specially developed systems that mimic the physical properties of various human tissues. They have been invaluable for developing and testing the thermal effects of hyperthermia [14]. Agar-based thermo-reversible gels consist of thick bundles of agar chains linked by hydrogen bonds, with pores holding water.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia

et al. 2019

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During hyperthermia, magnetite nanoparticles placed in an AC magnetic field become a source of heat. It has been shown that in fluid suspensions, magnetic particles move freely and generate heat easily. However, in tissues of different mechanical properties, nanoparticle movement is limited and leads to a small temperature rise in tissue. Therefore, it is crucial to conduct magnetic hyperthermia experiments in similar conditions to the human body. The effect of tissue-mimicking phantom compressibility on the effectiveness of magnetic hyperthermia was investigated on agar phantoms. Single and cluster nanoparticles were synthesized and used as magnetic materials. The prepared magnetic materials were characterized by transmission electron microscopy (TEM), and zeta potential measurements. Results show that tissue-mimicking phantom compressibility decreases with the concentration of agar. Moreover, the lower the compressibility, the lower the thermal effect of magnetic hyperthermia. Specific absorption rate (SAR) values also proved our assumption that tissue-mimicking phantom compressibility affects magnetic losses in the alternating magnetic field (AMF).

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Section: Introductionmentioning

confidence: 99%

The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia

et al. 2019

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“…Mechanical loading of hydrated materials such as cartilage tissue has also been shown to influence ultrasonic propagation velocity measurements (Nieminen et al, 2007). Tissue-equivalent phantoms may eventually aid in standardising the accuracy of developing cell-biomaterial construct measurements (Singh et al, 2008). …”

Section: Discussionmentioning

confidence: 99%

Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering

Kohles

Mason

Adams

et al. 2012

IJBET

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Non-destructive techniques characterising the mechanical properties of cells, tissues, and biomaterials provide baseline metrics for tissue engineering design. Ultrasonic wave propagation and attenuation has previously demonstrated the dynamics of extracellular matrix synthesis in chondrocyte-seeded hydrogel constructs. In this paper, we describe an ultrasonic method to analyse two of the construct elements used to engineer articular cartilage in real-time, native cartilage explants and an agarose biomaterial. Results indicated a similarity in wave propagation velocity ranges for both longitudinal (1500–1745 m/s) and transverse (350–950 m/s) waveforms. Future work will apply an acoustoelastic analysis to distinguish between the fluid and solid properties including the cell and matrix biokinetics as a validation of previous mathematical models.

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“…Other factors that may improve measurement variability could be considered. For phantom development and fabrication, additives such as glycerol (ultrasound velocity 1760 m/s) could be added to agar-based phantoms to increase and/or adjust the ultrasound velocity to a desired value [40].…”

Section: Future Workmentioning

confidence: 99%

Ultrasound elastography and characterization of soft tissue mimicking phantoms

Morehouse¹

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Ultrasound elastography, a noninvasive method of measuring the elastic properties of soft tissues, was investigated using a correlation technique. Phantoms, used in elastography research to mimic biological soft tissue, were fabricated to resemble a tumor using graphite powder as scatterers and two different agar concentrations, 2-w% and 3-w% agar for the background and tumor, respectively. Strain images were Table of Contents Ui List of Tables ? List ofFigures vi List of Symbols vi Acoustic Impedance Ns/m Acoustic Impedance of one material Ns/m3 Acoustic Impedance of second material Ns/m3 Xl

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Development of tissue-equivalent phantoms for biomedical ultrasonic applications

Cited by 5 publications

References 0 publications

The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia

The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia

Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering

Ultrasound elastography and characterization of soft tissue mimicking phantoms

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