Development of topical patches releasing allicin using garlic extract

Mahdi, Batool Mutar; Abu‐Huwaij, Rana; Al-Khateeb, Iqbal Hassan

doi:10.1111/jocd.14553

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The extraction process of allicin is simple, and high-purity allicin can be obtained through filtration, chromatography, and drawer. 36 Garlic is plentiful, easy to store and transport, and readily available almost anywhere in the world. The only downside of allicin may be its strong pungent odor.…”

Section: ■ Discussionmentioning

confidence: 99%

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Natural Compound Allicin Containing Thiosulfinate Moieties as Transmembrane Protein 16A (TMEM16A) Ion Channel Inhibitor for Food Adjuvant Therapy of Lung Cancer

Bai

Cheng

Wan

et al. 2022

J. Agric. Food Chem.

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Cancer is one of the most serious malignant diseases, and chemotherapy is cancer's main clinical treatment method. However, chemotherapy inevitably produces drug resistance, and side effects accompany them. Adjuvant therapy is an effective way to enhance chemotherapeutic drug sensitivity and reduce side effects. This study found allicin, garlic's active ingredient, is an inhibitor of transmembrane protein 16A (TMEM16A), a novel drug target of lung adenocarcinoma. Allicin concentrationdependently inhibited TMEM16A currents with an IC 50 of 24.35 ± 4.14 μM. Allicin thiosulfinate moieties bound with R535A/ E624A/E633A residues of TMEM16A blocked the ion transport function and downregulated TMEM16A protein expression affecting the mitogen-activated protein kinase signal transduction. Then, allicin reduced the viability and migration of LA795 cells, and induced cell apoptosis. Moreover, multitarget combination administration results indicated that the therapeutic effect of 3.56 mg/kg allicin and 3 mg/kg cisplatin combined administration was superior to the superposition of the two drugs alone, demonstrating that the anticancer effects of allicin and cisplatin were synergistic. In addition, low-concentration combined administration also avoided the side effects of cisplatin in mice. Based on the good tumor suppressor effect and high biosafety of allicin and cisplatin combination in vivo, allicin can be used for food adjuvant therapy of cisplatin chemotherapy.

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Section: ■ Discussionmentioning

confidence: 99%

“…A low concentration of allicin can synergistically promote DDP to cause anticancer effects. The extraction process of allicin is simple, and high-purity allicin can be obtained through filtration, chromatography, and drawer . Garlic is plentiful, easy to store and transport, and readily available almost anywhere in the world.…”

Section: Discussionmentioning

confidence: 99%

Natural Compound Allicin Containing Thiosulfinate Moieties as Transmembrane Protein 16A (TMEM16A) Ion Channel Inhibitor for Food Adjuvant Therapy of Lung Cancer

Bai

Cheng

Wan

et al. 2022

J. Agric. Food Chem.

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Development and characterization of magnetic hydrogels loaded with greenly synthesized iron-oxide nanoparticles conjugated with cisplatin

Shammeri,

Abu-Huwaij,

Hamed

2024

Pharmaceutical Development and Technology

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Natural Compounds Used for Treating Hair Loss

Bjørklund

Gasmi

Mujawdiya

et al. 2023

CPD

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Background: Hair loss or alopecia is a common dermatological condition affecting up to 2% of the world population. It is often caused by hereditary factors, such as male or female pattern baldness, but it can also result from various environmental factors, an unbalanced diet, or chronic illness. While hair loss is not life-threatening, it can cause significant anxiety, depression, and other psychological problems, ultimately impacting an individual's quality of life. <p> Objective: Various treatments for hair loss, including both synthetic drugs, such as minoxidil and finasteride, or medicinal herbs, have been approved by the Food and Drug Administration. Despite synthetic drugs' effectiveness, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating hair loss because many chronic disorders can cause alopecia. As such, this review focuses on identifying alternative, efficient treatment agents with limited side effects. Specifically, it looks into medicinal plants as potential healing agents for treating hair loss. <p> Methods: To gather relevant information for the study, multiple databases were searched, including Scopus, PubMed, and Google Scholar. A comprehensive search was conducted using a range of search terms, such as "hair loss," "alopecia," "natural remedies for hair loss," "herbal treatments for hair loss," and others to extract relevant scientific articles. <p> Results: Many medicinal plants and natural compounds have shown potential in reducing hair loss, thanks to their anti-inflammatory and antioxidant properties and the ability to improve local metabolism when applied externally. According to existing literature, herbal extracts and formulations derived from plants, such as Urtica dioica, Humulus lupulus, Serenoa repens, Vitis vinifera, Pygeum africanum, Cucurbita pepo, etc., as well as certain individual herbal compounds, micronutrients, bee products, and keratin, may be effective in reducing hair loss directly or indirectly. <p> Conclusion: Research suggests that medicinal plants and a variety of natural compounds hold promise in promoting hair growth and preventing alopecia.

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Development of topical patches releasing allicin using garlic extract

Cited by 3 publications

References 34 publications

Natural Compound Allicin Containing Thiosulfinate Moieties as Transmembrane Protein 16A (TMEM16A) Ion Channel Inhibitor for Food Adjuvant Therapy of Lung Cancer

Natural Compound Allicin Containing Thiosulfinate Moieties as Transmembrane Protein 16A (TMEM16A) Ion Channel Inhibitor for Food Adjuvant Therapy of Lung Cancer

Development and characterization of magnetic hydrogels loaded with greenly synthesized iron-oxide nanoparticles conjugated with cisplatin

Natural Compounds Used for Treating Hair Loss

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