Development of Treatment and Prophylactic Means with Selenium Nanoparticles on the Basis of Mineral Water of the Krasnoarmeysk Source for Application in Balneology

Nastueva, Madina; Компанцев, Д. В.; Sagradyan, G. V.; Privalov, Igor; Airapetova, Asya; Серов, А. В.

doi:10.2991/isils-19.2019.52

Cited by 2 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanoselenium has demonstrated potential applications in medicine as antibacterial (Gangadoo et al, 2020) and anticancer agents (Gangadoo et al, 2020; Kuršvietienė et al, 2020), drug delivery vehicles (Guan et al, 2018; Khurana et al, 2019), and for the treatment of neurodegenerative diseases (Sun et al, 2019). Nanoselenium is also used as a food additive (Skalickova et al, 2017) to prevent and treat selenium metabolism disorders in farm animals (Gangadoo et al, 2020), to enrich food (Folmanis et al, 2018), in plant growth (Yurkova & Omel'chenko, 2015), and in balneology (Nastueva et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Ryabova

Sutunkova

Minigalieva

et al. 2023

J of Applied Toxicology

View full text Add to dashboard Cite

This paper provides a comprehensive summary of the main toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals, up until February 28, 2023. A literature search revealed 17 articles describing experimental studies conducted on warm‐blooded animals. Despite some uncertainties, in vivo studies have demonstrated that selenium NPs have an adverse effect on laboratory animals, as evidenced by several indicators of general toxic action. These effects include reductions of body mass, changes in hepatotoxicity indices (increased enzyme activity and accumulation of selenium in the liver), and the possibility of impairment of fatty acid, protein, lipid, and carbohydrate metabolisms. However, no specific toxic action attributable solely to selenium has been identified. The LOAEL and NOAEL values are contradictory. The NOAEL was 0.22 mg/kg body weight per day for males and 0.33 mg/kg body weight per day for females, while the LOAEL was assumed to be a dose of 0.05 mg/kg of nanoselenium. This LOAEL value is much higher for rats than for humans. The relationship between the adverse effects of selenium NPs and exposure dose is controversial and presents a wide typological diversity. Further research is needed to clarify the absorption, metabolism, and long‐term toxicity of selenium NPs, which is critical to improving the risk assessment of these compounds.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Ryabova

Sutunkova

Minigalieva

et al. 2023

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

About combination of positive and negative outcomes of a subchronic exposure of rats to selenium oxide nanoparticles

et al. 2022

View full text Add to dashboard Cite

Introduction. Occupational contact with selenium and its compounds, including nanoscale forms, occurs in the glass production, rubber industry, metallurgy (metallurgical processes of copper sludge processing, copper pyrite roasting, manganese, selenium and tellurium production). There are scarce data on the toxicity of selenium nanoparticles. Material and methods. Stable suspensions of nanoparticles or deionized water (control group) were administered to male rats 3 times a week for 6 weeks. A single dose of selenium oxide nanoparticles was 0.2 or 1 or 2 mg/kg of body weight). The condition of the animal organism was assessed with a number of indicators of toxic action at the end of the experiment. The statistical significance of intergroup differences was assessed by Student's t-test. Results. Activity of succinate dehydrogenase in blood lymphocytes reflecting the intensity of energy processes in the organism was decreased. The number of eosinophils in smears-imprints of parenchymal organs and mesenteric lymph nodes increased, indicating the ability of selenium nanooxide to trigger signaling cascades in immunocompetent cells. The number of degenerated cells in the proximal and distal tubules in smears of the kidneys was increased. A tendency to a decrease in all hemodynamics parameters was found. A change in the QT duration, together with an increase in the amplitude of the T wave, probably indicates a violation of the processes of myocardial repolarization. The coefficient of fragmentation of genomic DNA in nucleated blood cells decreased. Limitations. The research was limited to the study of indicators of toxic action in only one study using a limited dose range. Conclusion. An ambiguous effect of selenium oxide nanoparticles on rats was found. Along with negative impact of nanoparticles we have demonstrated, for the first time, some beneficial outcomes, in particular, genome -protective action which is in a striking contrast with the genotoxicity of all elemental and element-oxide nanoparticles previously studied in our laboratory.

show abstract

Development of Treatment and Prophylactic Means with Selenium Nanoparticles on the Basis of Mineral Water of the Krasnoarmeysk Source for Application in Balneology

Cited by 2 publications

References 3 publications

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Toxicological effects of selenium nanoparticles in laboratory animals: A review

About combination of positive and negative outcomes of a subchronic exposure of rats to selenium oxide nanoparticles

Contact Info

Product

Resources

About