The main objective of the planned experiment is to obtain a stabilized nanoemulsion of vitamin D3, followed by obtaining nanocapsules of vitamin D3 with a high biological potential, as well as to analyze the spatial (dimensional) characteristics, to study the stability and stability of the resulting product. In the presented study, the physicochemical and technological properties of the vitamin D substance were studied and the optimal ultradispersion mode was selected. The composition is experimentally established and a technology for obtaining laboratory samples of nanocapsules is proposed. The shape and size of the obtained nanocapsules with vitamin D were studied. Based on the developed experimental model, the optimal composition of nanocapsules was obtained. The quantitative content of vitamin D3 in the analyzed sample of nanocapsules was 76.9% with a holding time of 2.0 min. The results of studying the stability and stability of vitamin D nanocapsules proved their stability for 12 months. The developed vitamin D nanocapsules are a way of modifying the vitamin D substance for the subsequent production of tablets with improved biopharmaceutical properties. The selection of the composition of excipients based on the prediction of their properties, as well as the technology for producing nanocapsules, allows to increase the duration of the therapeutic effect while simultaneously reducing the maximum concentration of the drug in the body. The optimal composition of solubilizers for achieving a more complete, rapid and targeted dissolution of the active substance in a given part of the intestine has been experimentally confirmed. The aim of the study is to obtain a quality drug with improved properties such as adequate bioavailability, safety, low toxicity, no side effects and controlled release.

In the course of our research we have developed a technology for fabricating an osteoplastic material from natural bone tissue. The obtained preparation in the form of gel contains hydroxyapatite, calcium triphosphate compounds and stimulators for regeneration. The proposed experimental material produces a stimulating effect on the growth of animal cell types; it enables to produce bioactive materials with increased biocompatibility. Application of the experimental gel facilitates the process of bone-tissue regeneration in the laboratory animals, which, in its turn, confirms the optimal composition of the material. We have established that during the integration of our osteoinductive material the defect zone is completely replaced by the bone tissue.

The purpose of the study is development technology of receiving mineral waters with nanoparticles of selenium and studying of their stability. The studied samples the concentrated solution of nanoparticles of selenium contens selenium about 1,4 mg/ml, mineral water of the Krasnoarmeysky source. The expediency, reliability and informational content of a method of photon correlation spectroscopy are shown for assessment of changes in system mineral waternanoparticles on a nanolevel. Results of researches on studying of aggregate stability of nanoparticles of selenium with a hydrodynamic radius-37,5-38 nanometers by mixing with mineral water of the Red Army source are presented in article. The stability of the mixtures was evaluated by the size of dispersed particles. In particular stability of particles directly after mixing and under the influence of various physical factorsultrasonic radiation, an exposition by direct sunlight, the lowered temperature and room temperature is studied. After of storage, the parameters of each of the solutions were studied. As a result of the conducted research the conclusion is drawn that the sample has the maximum stability which prepared by simple mixing at the same time at storage him at the lowered temperature of a particle have the smallest diameter and least are exposed to stratification on fraction. Keywords-nanoselenium, mineral water of the Krasnoarmeysky source, method of photon correlation spectroscopy, stability of nanoparticles, aggregate stability I.

New tablets possessing anti-arthrosis properties have been created. The basic active agents in this preparation are glucosamine sulfate and methylmethanesulfonate (mesylmethane, MM). It is established that glucosamine in combination with willow-bark extract exhibits more pronounced specific activity. It is suggested to determine the quantitative content of MM by a gas chromatographic (GC) method with the use of a working reference sample. The validation has been carried out. The metrological performance of the proposed method is characterized. The calculated validation parameters confirmed the applicability of GC to the quantification of MM in the anti-arthrosis tablets. 479 0091-150X/08/4208-0479

В статье приводится обзор исполь-зования мальтодекстрина в качестве од-ного из действующих веществ в лекарст-венных формах для наружного примене-ния, используемых при лечении гнойных и воспалительных процессов за рубежом. Также в статье рассматривается перспек-тива создания импортозамещающих пре-паратов на основе мальтодекстрина оте-чественного производства.Ключевые слова: мальтодекст-рин, D-глюкоза-полисахарид, раны, язвы.The article reviews the use of maltodextrine as one of the active substances in external drug forms which are used in purulent and inflammatory processes treatment abroad. The article considers a manufacturing prospect of import-substituting preparations on the basis of domestic maltodextrin.Keywords: maltodextrin, glucosepolysaccharide, wounds, ulcers.Гнойные раны -наиболее часто встречающиеся поражения, составляют около 30% от заболеваний кожи. На ам-булаторно-поликлиническом приеме хи-рурга они составляют почти 70 %. Не-правильное лечение подобных пораже-ний может привести к серьезным послед-ствиям таким, как сепсис, гангрена, инва-лидность.Независимо от этиологии гнойных поражений в раневом процессе выделяют этапы воспаления, регенерации и эпите-лизации. При лечении гнойных ран необ-ходимо учитывать особенности каждого этапа процесса. То есть, необходимо со-блюдать и поддерживать определенную влажность, температуру и воздухообмен в ране. Также, не менее важно учитывать изначальное состояние раны (влажная, мокнущая или сухая) и степень заражен-ности микроорганизмами. Только соблю-дение всех вышеуказанных условий по-зволит достичь не только оптимального лечебного, но и косметического эффекта [7].Можно сделать вывод о том, что лечение гнойных ран является крайне трудным процессом и требует системного подхода. На внутреннем рынке РФ пред-ставлен большой ассортимент различных средств, предназначенных для регенера-ции и санации повреждений кожи. Одна-