Gas-chromatographic determination of methylmethanesulfonate in anti-arthrosis tablets

Abstract

New tablets possessing anti-arthrosis properties have been created. The basic active agents in this preparation are glucosamine sulfate and methylmethanesulfonate (mesylmethane, MM). It is established that glucosamine in combination with willow-bark extract exhibits more pronounced specific activity. It is suggested to determine the quantitative content of MM by a gas chromatographic (GC) method with the use of a working reference sample. The validation has been carried out. The metrological performance of the proposed method is characterized. The calculated validation parameters confirmed the applicability of GC to the quantification of MM in the anti-arthrosis tablets. 479 0091-150X/08/4208-0479

Trace analysis of residual sulfonate esters in Simvastatin by capillary gas chromatography-mass spectrometry

“…9,10 Therefore, in order to meet the regulatory requirements and to protect patient safety, it is essential to develop a sensitive analytical method that can identify and determine MMS, EMS, Mp-TS and Tp-TS in Simvastatin. Some researchers have used GC 11,12 or GC-MS [13][14][15] for determination of two or three sulfonate esters. However, few analytical methods have been reported for the identification and determination of four sulfonate esters simultaneously in Simvastatin.…”