Development of Urea Crosslinked Thin Film for Biomedical Application

Rahman, Mahmudur; Islam, Jahid M. M.; Hassan, M. Manjur; Habib, S. M. Ahsan; Pervez, Md. Sarwar; Khan, Manzoor Ahmed

doi:10.1080/00914037.2013.769228

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…The effect of urea on this microcrustacean has been studied in the past, 58 and more recently. 35,59,60 Tests with organisms belonging to different species and trophic levels may be necessary to evaluate the toxic effect of PBS microspheres on these organisms and on the ecological interactions in which they take part. 61 For this reason, biostimulation experiments with bacterial culture characteristic of environments contaminated with HCs were conducted in order to evaluate the possible effect of PBS U and PBS E matrices on growth and substrate consumption by the biological lineage of the species different from that used in the ecotoxicity test.…”

Section: Assays Of Ecotoxicity and Mortalitymentioning

confidence: 99%

Production and toxicological evaluation of poly(butylene succinate)–urea microspheres targeting bioremediation

Bedor

Rondelli

Filho

et al. 2021

J of Chemical Tech & Biotech

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BACKGROUND: As population and fuel demand increase, many events of oil spills in the environment have been recorded. In order to restore these environments, several techniques have been proposed in the literature, especially in the field of bioremediation, with their main advantage being a low impact on the environment. In this work, poly(butylene succinate) microspheres containing urea were produced, representing a source of controlled release of nitrogen to the environment, promoting the biostimulation of the native microbiota of contaminated sites. Experiments were conducted based on the biostimulation of Pseudomonas aeruginosa and assessed the growth of the culture, the controlled release of urea, the substrate consumption and the toxicity of the microspheres using Artemia salina. RESULTS:The results showed that the double-emulsion methodology for urea encapsulation was efficient, with controlled release occurring up to 72 h. The urea-containing microspheres promoted microbial growth with higher protein synthesis (198.66 ∼g mL −1 ) in 72 h, from the consumption of glucose and urea, within the release limitations. The ecotoxicity of the urea-containing microspheres was tested with A. salina and the results showed a CL50 of 0.027 mg (10 mL) −1 , not recommending its use in the aquatic environment for this organism. CONCLUSIONS:The assays revealed that poly(butylene succinate) microspheres, both with urea and without this active ingredient, may not present toxicity to microorganisms such as P. aeruginosa and be toxic to more complex organisms such as A. salina.

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Section: Assays Of Ecotoxicity and Mortalitymentioning

confidence: 99%

Production and toxicological evaluation of poly(butylene succinate)–urea microspheres targeting bioremediation

Bedor

Rondelli

Filho

et al. 2021

J of Chemical Tech & Biotech

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“…In vitro cytotoxicity test was performed using brine shrimp lethality bioassay, as suggested by Rahman et al (2013). Brine shrimp lethality bioassay is a primary toxicity screening procedure used as an initial screening of bioactive compounds.…”

Section: In Vitro Cytotoxicity Studymentioning

confidence: 99%

Gelatin-based instant gel-forming volatile spray for wound-dressing application

Islam

Rahman

et al. 2021

Prog Biomater

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This study was a successful endeavor to develop and investigate the suitability of a bioadhesive wound-healing gel based on gelatin for first-aid purposes. Polyethylene glycol (PEG) was used to prepare a denser phase of gelatin chains, and diethyl ether (DEE) was used to introduce high volatility to the solution. The prepared solution was stable in the storage container but rapidly formed (within 3 s) a protective and bioadhesive gel around the wound surface by being sprayed over the wound. Besides, it also suppressed pain and showed moderate antimicrobial activity against S. aureus. It was also found highly biocompatible and non-toxic. All the results revealed that the prepared solution could be an effective candidate for treating minor injuries or burn, especially for a first-aid purpose.

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“…The low percent mortality of the hydrogel samples may be due to the formation of viscous layers on the gills of the nauplii; this eventually inhibits the oxygen permeability and causes the deaths of nauplii and an increase in the percent mortality beyond the optimum concentration (150 mL) of TEOS. 55 4.10 Drug release proles 4.10.1. Drug release proles in PBS and SIF solutions.…”

Section: Cytotoxicity Analysismentioning

confidence: 99%